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Background: Lewy body Dementia (LBD) is a well-known neurocognitive disorder in the elderly. The hallmarks of LBD are Parkinsonism without tremor, recurrent and persistent visual hallucinations often with insight, fluctuating cognition and alertness, rapid eye movement (REM) sleep behavior disorder with vivid dreams and violent movements, but relatively preserved memory functions. Nevertheless, LB
Library assessment and external intelligence is important for tracking and improving library activities. Quality assurance and strategic planning are intricate parts in sustainably developing better and more effective services. Gothenburg University Library has implemented a process with the goal to join these activities. The process has both bottom-up and top-down features designed to generate st
With the use of genetic technology, researchers have the potential to inform medical diagnoses and treatment in actionable ways. Accurate variant interpretation is a necessary condition for the utility of genetic technology to unfold. This relies on the ability to access large genomic datasets so that comparisons can be made between variants of interest. This can only be successful if DNA and medi
Objectives Patients ≥65 years old represent 30%-50% of all ambulance assignments (AAs), and the knowledge of which care level they are disposed to is limited and diverging. The aim of this study was therefore to describe and compare characteristics of patients' aged ≥65 years dispositions during AA, including determining changes over time and factors associated with non-conveyance to hospitals. De
Background: Evidence-based guidelines are needed for effective delivery of home oxygen therapy to appropriate patients with chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD). Methods: The multidisciplinary panel created six research questions using a modified Delphi approach. A systematic review of the literature was completed, and the Grading of Recommendations Asse
Chronic prurigo (CPG) is a highly burdensome pruritic disease characterized by chronic itch, a prolonged scratching behavior and the development of localized or generalized hyperkeratotic pruriginous lesions. Neuronal sensitization and the development of an itch-scratch cycle contribute to the augmentation of pruritus and the chronicity of the disease. We provide here the first international guide
Introduction: The extent to which pain is distributed across the body (spreading of pain) differs largely among patients with chronic pain conditions and widespread pain has been linked to poor quality of life and work disability. A longer duration of pain is expected to be associated with more widespread pain, but studies are surprisingly scarce. Whether spreading of pain is associated with clini
Drainage networks are the basis for segmentation of watersheds, an essential component in hydrological modelling, biogeochemical applications, and resource management plans. With the rapidly increasing availability of topographic information as digital elevation models (DEMs), there have been many studies on DEM-based drainage network extraction algorithms. Most of traditional drainage network ext
Aims Optimal antithrombotic therapy after percutaneous coronary intervention (PCI) in patients with myocardial infarction (MI) and atrial fibrillation is uncertain. In this study, we compared antithrombotic regimes with regard to a composite cardiovascular outcome of all-cause mortality, MI or ischaemic stroke, and major bleeds. Methods and results Patients between October 2005 and December 2012 w
PURPOSE: To study newly diagnosed glaucoma patients given mono- or multi-therapy regarding differences in initial intraocular pressure (IOP) reduction, target IOP levels reached and influence of untreated baseline IOP on IOP reduction.METHODS: Patients newly diagnosed with manifest primary open-angle glaucoma and included in the Glaucoma Intensive Treatment Study (GITS) were randomized to immediat
Wind energy is an important source of bat mortality worldwide. Extensive mortality data were gathered by a provincial surveillance program carried out at wind farms in lowland Mediterranean areas of the province of Cadiz, Andalusia (South Spain) between 2005 and 2016. As many as 2,371 bat fatalities were found. We determined the patterns of fatality in this sample and tested the quality of the sur
Context: Patients with advanced cancer commonly suffer from both distressing symptoms and cognitive impairment, but the effect of cognitive impairment on the reliability and validity of symptom self-report is unknown. Objectives: To evaluate the reliability and validity of symptom self-report in cancer outpatients with and without mild to moderate cognitive impairment. Methods: This was an analysi
Background: This study aims to investigate how increased nasal resistance affects respiratory variables in obstructive sleep apnea (OSA). In this setting, to assess how nasal resistance, as measured by 4-phase rhinomanometry, affects the distribution of hypopneas and apneas when measured with routine Sleep Polygraphy (PG). Methods: PG recordings were analysed and 4-phase rhinomanometry was conduct
Background: Time of diagnosis (TOD) of benign esophageal perforation is regarded as an important risk factor for clinical outcome, although convincing evidence is lacking. The aim of this study is to assess whether time between onset of perforation and diagnosis is associated with clinical outcome in patients with iatrogenic esophageal perforation (IEP) and Boerhaave’s syndrome (BS). Methods: We s
This paper presents a selection of epigraphic documents dispersed over three quarry faces (C11–C13) in the Main Quarry (Q34) at Gebel el-Silsila’s east bank, dating from the reign of the Emperor Augustus. The aim is to describe and decipher the various marks and depictions, and to translate the Demotic and Greek texts, in order to determine for what structure the stone from the quarry was intendedThis paper presents a selection of epigraphic documents dispersed over three quarry faces (C11–C13) in the Main Quarry (Q34) at Gebel el-Silsila’s east bank, dating from the reign of the Emperor Augustus. The aim is to describe and decipher the various marks and depictions, and to translate the Demotic and Greek texts, in order to determine for what structure the stone from the quarry was intended
Negative impact of human activity-related emission of greenhouse gases on Earth's ecosphere has been known for decades, but has recently come into spotlight with unprecedented intensity. This is due to increasingly clear understanding that the global warming could soon spiral out of control. It is therefore essential to diminish the use of fossil fuels and switch to renewable energy sources. Despi
An overview is provided of the 15 neutron beam instruments making up the initial instrument suite of the European Spallation Source (ESS), and being made available to the neutron user community. The ESS neutron source consists of a high-power accelerator and target station, providing a unique long-pulse time structure of slow neutrons. The design considerations behind the time structure, moderator
The retina is a thin tissue layer on the inside of the eye and may be subject to tractional forces in diseases like myopia, retinoschisis, and retinal detachment. Müller glial cells (MGCs) are the only cells spanning the entire retinal thickness and hypothetically respond to mechanical stress imposed across retinal layers. We designed a device to apply force in vitro perpendicular to the retinal sThe retina is a thin tissue layer on the inside of the eye and may be subject to tractional forces in diseases like myopia, retinoschisis, and retinal detachment. Müller glial cells (MGCs) are the only cells spanning the entire retinal thickness and hypothetically respond to mechanical stress imposed across retinal layers. We designed a device to apply force in vitro perpendicular to the retinal s
Background: Colon capsule endoscopy (CCE) offers direct mucosal visualisation without sedation or gas insufflation required in conventional colonoscopy (CC). However, evidence for the role of CCE as an adjunct or alternative to CC remains equivocal. In this observational cohort study, we report our experience of using CCE to investigate patients with suspected colon pathology at a tertiary referra
