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The universally recognised action spectrum for the UV-induced conversion of 7-dehydrocholesterol to previtamin D3 in human skin was published in 1982, and indicates a maximum at about 297 nm with essentially no production above 315 nm. This work represents a milestone in research on vitamin D, but limitations in the original data should be recognised. Various findings have arisen in recent years w
Whistle-blowing can serve as a powerful mechanism helping policy-makers and other stakeholders recognize ethical misconduct and other types of wrongdoing in autonomous public agencies. This mechanism is of particular importance in major public sector reforms, such as agency mergers, when it may be difficult to secure continuity in the quality of organizational processes. Yet, we know little of wha
In the present study, the involvement of cytochrome P450 enzyme( s) in the primary metabolism of laquinimod, a new orally active immunomodulator, has been investigated in human liver microsomes. Hydroxylated and dealkylated metabolites were formed. The metabolite formation exhibited single enzyme Michaelis-Menten kinetics with apparent K-M in the range of 0.09 to 1.9 mM and V-max from 22 to 120 pm
Fokus för forskningen kan sammanfattas med orden vardag, hälsa och välbefinnande. Aktivitet, dess komplexitet, mening och vilken betydelse det har för människors upplevelse av hälsa och välbefinnande – är centralt. Vi som är organiserade i gruppen arbetar i varierande omfattning med undervisning, forskning och med att sprida våra resultat till brukare och olika verksamheter i samhället.The research in the Occupational therapy and occupational science-group is focused on occupation, health and wellbeing. The complexity, meaning and importance of the concept of everyday occupations for people’s health, is the key. The group works to a varying extent at teaching, research and dissemination of our results to users, in the society.
Substrate and product inhibition of hydrogen production during sucrose fermentation by the extremely thermophilic bacterium Caldicellulosiruptor saccharolyticus was studied. The inhibition kinetics were analyzed with a noncompetitive, nonlinear inhibition model. Hydrogen was the most severe inhibitor when allowed to accumulate in the culture. Concentrations of 5-10 mM H2 in the gas phase ( partial
It is now more than two decades since Jane Summerton published her landmark book District Heating Comes to Town about the successful development of a district heating system in an ‘ordinary’ town in Sweden. It was published when sociotechnical studies of urban technical systems were still relatively rare, and arrived during a fertile period of intellectual development that was striving to connect
District heating systems make an important puzzle piece in the energy system of both today and tomorrow. When designing, simulating and controlling these systems, hydraulics play a vital role. The pressure generated by pumps has to drive sufficient flow throughout the system to satisfy the requirements of customers. Ensuring that the system is sufficiently pressurized is a challenging task already
Cloud RAN (C-RAN) is a promising paradigm for the next generation radio access network infrastructure, which offers centralised and coordinated base-band signal processing in a cloud-based BBU pool. This requires extremely low latency responses to achieve real-time signal processing. In this paper, we analysed the challenges to introduce cloud native model for signal processing in C-RAN. We studie
Dokument-ID 09222115557577971627 Signerat CW, VÖ, EU, JA, MEA, UR, CE, EB, HP, ME INNEHÅLLSFÖRTECKNING FÖRVALTNINGSBERÄTTELSE.............................................................................................................................. 3 SAMMANFATTNING AV INNEHAV 2025 .................................................................................................................1
This paper attempts to address the failings of a predominant paradigm in IS research and practice that emphasises technological determinism. This paradigm makes use of a false belief in the power of rationality in organizational decision-making, and a mythology in which organizational actors can be viewed as passive ‘users’ of technology. We wish to create a discussion of the nature and role of pr
Following the 2008–2009 global financial crisis, ‘green energy economy’ packages have been implemented to stimulate sustainable economic growth in several Organisation for Economic Co-operation and Development (OECD) countries. Clearly focused on the energy sector, these packages typically include energy-efficiency policy measures and aim to encourage the transition towards a low-carbon economy. W
The need for affordable housing requires more compact living. With the increasing frequency and impact of climate change incidents, a new way of thinking is needed to live in a more resilient and climate responsive way. The idea of a Z free home began by considering these two needs. As a tiny mobile house equipped with passive and eco-cycle systems, it achieves 9 zero targets. This paper evaluates
Reduced energy consumption is an important strategy for climate change mitigation. Buildings, worldwide, accounts for 40 % of the primary energy use and 24 % of greenhouse gas emissions.There are studies and publications indicating that problems with high indoor temperature during summer are increasing in residential buildings designed as passive houses and low-energy buildings.The objective of th
Protection against mucosally transmitted infections probably requires immunity at the site of pathogen entry(1), yet there are no mucosal adjuvant formulations licensed for human use. Polyethyleneimine (PEI) represents a family of organic polycations used as nucleic acid transfection reagents in vitro and DNA vaccine delivery vehicles in vivo(2,3). Here we show that diverse PEI forms have potent m
