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Systemic sclerosis (SSc) is an autoimmune disease that shows one of the highest mortality rates among rheumatic diseases. We perform a large genome-wide association study (GWAS), and meta-analysis with previous GWASs, in 26,679 individuals and identify 27 independent genome-wide associated signals, including 13 new risk loci. The novel associations nearly double the number of genome-wide hits repo

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This thesis discusses two cases of rape against adolescent girls that happened in Cianjur, West Java, and Lombok, West Nusa Tenggara in Indonesia. First of all, the thesis evaluates the availability of the legal framework in the area of rape in Indonesia that ensures the victims rights with regard to rape. It will look at whether Indonesia has ratified relevant international human rights instrumen

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Ben Ali’s authoritarian rule over Tunisia was caused by corruption, nepotism, and unemployment. I aim to show that the downfall of the regime was enhanced by the repression of freedom of expression. Limiting access to information creates struggle for people in their daily lives; they become more dissatisfied and the will to create change becomes stronger. Repressing freedom of expression to hide t

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Summary The EU and the Member States are concerned about VAT fraud and they consider it necessary to reduce the gap the VAT fraud makes. The purpose of this thesis is to describe three methods that are used in the fight against VAT fraud. Those methods are the reverse charge mechanism, joint and several liability and the knowledge test. Those methods are described, defined how they are used and wh

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A growing number of environmental movements recognize the need for changing our spiritual approach to the environment, while we simultaneously witness a revival and development of ecotheologies and religiously motivated environmental initiatives. Islamic theological discourse on ecological issues is quite well studied, but less attention has been directed to how Islamic ecology has been translated

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In this Master Thesis different methods for measuring and evaluating surface textures have been investigated and evaluated. A method for digitizing textures called photometric stereo have also been studied. The purpose has been to find methods that can replace or supplement the current method of visual inspection used for surface texture studies by IKEA of Sweden. The suggested methods are going t

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The concept of “Rechtsstaat” developed in the 1830s and 1840s in the German constitutional discussion. Robert von Mohl developed the concept in a substantive sense and Friedrich Julius Stahl then developed it in a formal sense. In this article, the theories of the two scholars are first explained and analysed in the context of their understandings of the State and the law as well as the philosophi

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It’s clear that human activities have heated our climate via the release of anthropogenic greenhouse gases. Recent changes within the earth climate are rapid, intensifying, and unprecedented. With each additional increment of warming, climate change is impacting ecosystems through changes in average conditions, climate variability, coupled with other associated changes such as biodiversity loss an

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Blood biomarkers indicative of Alzheimer’s disease (AD) pathology are altered in both preclinical and symptomatic stages of the disease. Distinctive biomarkers may be optimal for the identification of AD pathology or monitoring of disease progression. Blood biomarkers that correlate with changes in cognition and atrophy during the course of the disease could be used in clinical trials to identify

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This report proposes a capability assessment framework for countering disinformation, information influence, and foreign interference. At present, much emphasis is placed on the capability to counter disinformation and other associated phenomena. However, few have attempted to systematically define what those countermeasures are, and how they could be placed within a single, coherent capability as

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The Global Hyperorgan is an intercontinental, creative space for acoustic musicking. Existing pipe organs around the world are networked for real-time, geographicallydistant performance, with performers utilizing instruments and other input devices to collaborate musically through the voices of the pipes in each location. A pilot study was carried out in January 2021, connecting two large pipe org

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Few studies have explicitly explored regional embeddedness and both the inconsistencies and injustices of circular bioeconomy (CBE) innovations. To better navigate the normative dimension of these innovations and CBE transitions in general, our article presents a threefold argument for the relevance of the regional level of analysis. First, CBE innovations are influenced by and affect regional met

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The chapter discusses the use of citizenship and statelessness as a political tool by states during the turmoil in the Middle East North Africa during the "Arab Spring".

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Drawing upon literature from both impact assessment of development projects and agricultural research, the aim of this article is to analyse the pilot testing of a new multi-dimensional assessment framework for defining and evaluating the societal impact of agricultural research and corresponding education. The research approach involves an action research effort of pilot testing in three case stu

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Let NDTIME(f(n),g(n)) denote the class of problems solvable in O(g(n)) time by a multi-tape Turing machine using an f(n)-bit non-deterministic oracle, and let DTIME(g(n)) = NDTIME(0, g(n)). We show that if the all-pairs shortest paths problem (APSP) for directed graphs with N vertices and integer edge weights within a super-exponential range { -2Nk+o(1),.,2Nk+o(1)}, k≥1 does not admit a truly subc