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Polyethyleneimine (PEI) is an organic polycation used extensively as a gene- and DNA vaccine delivery reagent. Although the DNA targeting activity of PEI is well documented, its immune activating activity is not. We recently reported that PEI has robust mucosal adjuvanticity when administered intranasally with glycoprotein antigens. Here we show that PEI has strong immune activating activity after

Transcription factors involved in the specification and differentiation of neurons often continue to be expressed in the adult brain, but remarkably little is known about their late functions. Nurr1, one such transcription factor, is essential for early differentiation of midbrain dopamine (mDA) neurons but continues to be expressed into adulthood. In Parkinson's disease, Nurr1 expression is dimin

Talent Management is a vague concept that is covering everything from recruiting, developing and retaining talents within organisations. A constant challenge in this field is to develop new generations within the workforce to fit what the organisation needs in order to do business. Generations are said to be shaped after historical and political factors that are impacting their behaviors and requi

Mitochondria play essential roles in plant metabolism, supporting both development and stress responses. To maintain a healthy pool of mitochondria, several quality control systems are in place. Selected degradation of mitochondria by autophagy -mitophagy- has been extensively studied in yeast and animals, but information on mitophagy components in plants is limited. The ‘Friendly Mitochondria’ (F

A few large fires in Lithium-ion battery systems are known to have been caused by leaking coolant, and experience from fire testing indicate that coolant can be the origin of violent fires triggered before the onset of thermal runaway in the battery. It is here hypothesized that the common coolants water and ethylene glycol can form flammable gases via electrolysis in the electrical environment fo

The increased schizophrenia risks for residents of cities with high levels of competition and for members of disadvantaged groups (for example migrants from low- and middle-income countries, people with low IQ, hearing impairments or a history of abuse) suggest that social factors are important for aetiology, Dopaminergic dysfunctioning is a key mechanism in pathogenesis. This editorial is a selec

BACKGROUND: Elevated plasma levels of heparin-binding protein (HBP) are associated with risk of organ dysfunction and mortality in sepsis, but little is known about causality and mechanisms of action of HBP. The objective of the present study was to test the hypothesis that HBP is a key mediator of the increased endothelial permeability observed in sepsis and to test potential treatments that inhi

Infection with the human gastric pathogen Helicobacter pylori can give rise to chronic gastritis, peptic ulcer, and gastric cancer. All H. pylori strains express the surface-localized protein HpaA, a promising candidate for a vaccine against H. pylori infection. To study the physiological importance of HpaA, a mutation of the hpaA gene was introduced into a mouse-adapted H. pylori strain. To justi

Massive MIMO (MaMI) is often promoted as a technology that will enable the use of low-quality, cheap hardware. One particular component that has been in the focus of MaMI-related research is the analog-to-digital converter (ADC), and use of very low-resolution ADCs has been proposed. However, studies about whether this strategy is justified from an energy-efficiency point of view have largely been

Neurons are continuously generated from stem cells in the hippocampus and along the lateral ventricles in the adult brain. Neural stem cells can be propagated in vitro in the presence of epidermal growth factor (EGF) or fibroblast growth factor-2. We report here that amphiregulin, a growth factor related to EGF, is a mitogen for adult mouse neural stem cells in vitro and displays potency similar t

The present minireview of the place of cystatin C in clinical medicine emphasizes, and discuss the evidence, that cystatin C-based GFR-estimating equations do not require the use of vague terms like race and sex, that cystatin C-based GFR-esti mating equations are useful for both children and adults, including the elderly, that the best GFR-estimation requires simultaneous use of both cystatin C-

Electric vehicles could help reduce greenhouse gas emissions and deliver a sustainable transport system. But the full life cycle of electric vehicles needs to be considered in order to avoid creating resource issues while trying to achieve the necessary climate goals.

Terminal differentiation of mammalian erythroid progenitors involves 4-5 cell divisions and induction of many erythroid important genes followed by chromatin and nuclear condensation and enucleation. The protein levels of c-Myc (Myc) are reduced dramatically during late stage erythroid maturation, coinciding with cell cycle arrest in G1 phase and enucleation, suggesting possible roles for c-Myc in