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Syftar till att genom olika projekt bidra till ökad patientsäkerhet och till kvalitetsförbättringar inom sjukvården. Kunskap och erfarenheter utvecklas kring hur vårdgivare, både som individer och som sjukvårdssystem, kan erbjuda patienter en säkrare vård. Arbetet genomförs i interprofessionellt samarbete inom det medicinska/sjukvårdsområdet, men också i samverkan med andra vetenskapsområden, så Aims through different projects at improved Patient safety and Quality improvements within the healthcare system. Knowledge and experiences about how healthcare providers, both as individuals and as an organization, can provide a safer healthcare to patients are developed. This work is carried out through interprofessional collaboration within the medical/healthcare field, but also through collabo

Profilområdet utvecklar tvärvetenskapliga och gränsöverskridande hälsofrämjande strategier och metoder för proaktivt åldrande. Området fokuserar särskilt på kognitiv och muskuloskeletal hälsa som förutsättningar för aktivitet och delaktighet. Profilområdet ska utveckla metoder för att tidigt identifiera individer och grupper i riskzonen för ohälsa eller annan utsatthet med hjälp av ekonomiska, socThe profile area develops transdisciplinary health promotive strategies for proactive ageing. It focuses particularly on cognitive functions and musculoskeletal health as prerequisites for activity and participation. The profile area will develop methods for early identification of individuals and groups at risk of poor health or other vulnerabilities, using economic, social as well as biological

The kinin B1 receptor (B1R) is a G protein-coupled receptor with pro-inflammatory activity that is latent in healthy tissues but induced by tissue insult. Here, we investigated if B1R homo-oligomerization is a possible mechanism regulating the presentation of this receptor at the level of maturation and trafficking to the cell surface. To this end, we used HEK293 cells stably expressing N-terminal

The use of Islamic symbols in metal music has, until now, been a rare phenomenon. A few years ago, some black metal-bands in Istanbul started using Islamic symbols in both their artwork and lyrics, often in an anti-Islamic fashion. Although research on metal music is well established, little has been done on the relationship between black metal and Islam. This thesis explores the relationship betw

A review of the current evidence for internal fixation versus hemiarthroplasty versus primary total hip arthroplasty for displaced femoral neck fractures was undertaken. At the meta-analysis level no difference in postoperative pain, function, or quality of life can yet be demonstrated. A significant difference in mortality has also not been found, but a trend towards higher mortality after primar

Commercialization has been recognized as one of the most difficult phases of the innovation process. Failure rates are high, even for products with the potential to address real needs and deliver real customer value. This master's thesis explores commercialization in an even more challenging business context than the typical case. First, the innovating company is an early startup with limited

The purpose of this report is to map how HTA, Health Technology Assessment, is being used for MDD products for inpatient care in Sweden. Swedish Medtech, a professional association for medical technology companies, has a need to carry out a survey about the use of HTA in Sweden for their future work. They have a project which goal is to inform policy makers about the value of innovative medical pr

Background. Synthetic colloids cause dilutional coagulopathy. The aims of our study were to determine whether the natural colloid albumin induces a lesser degree of coagulopathy compared to synthetic colloids, and the comparative effectiveness of fibrinogen concentrate to reverse coagulopathy following dilution with these solutions. Methods. Coagulation was assessed with rotational thrombelastomet

The actinomycete Corynebacterium glutamicum grows as rod-shaped cells by zonal peptidoglycan synthesis at the cell poles. In this bacterium, experimental depletion of the polar DivIVACG protein resulted in the inhibition of polar growth; consequently, these cells exhibited a coccoid morphology. This result demonstrated that DivIVA is required for cell elongation and the acquisition of a rod shape.

A key step in lipolytic activation of adipocytes is the translocation of hormone-sensitive lipase (HSL) from the cytosol to the surface of the lipid storage droplet. Adipocytes from perilipin-null animals have an elevated basal rate of lipolysis compared with adipocytes from Wild-type mice, but fail to respond maximally to lipolytic stimuli. This defect is downstream of the p-adrenergic receptor-a

This paper is a study of women in Belfast in two working-class ethno-national communities: Falls (Catholic/Nationalist/Republican) and Shankill (Protestant/Unionist/Loyalist). Theories of gendered nationalism and transversalism are used to analyze the material from a qualitative interview study. The study focuses on intersections of gender and nation: women’s identity as biological, cultural and n

The capacity to learn and reproduce vocal sounds has evolved in phylogenetically distant tetrapod lineages. Vocal learners in all these lineages express similar neural circuitry and genetic factors when perceiving, processing, and reproducing vocalization, suggesting that brain pathways for vocal learning evolved within strong constraints from a common ancestor, potentially fish. We hypothesize th

Here we describe the parametric response map (PRM), a voxel-wise approach for image analysis and quantification of hemodynamic alterations during treatment for 44 patients with high-grade glioma. Relative cerebral blood volume (rCBV) and flow (rCBF) maps were acquired before treatment and after 1 and 3 weeks of therapy. We compared the standard approach using region-of-interest analysis for change