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Circularity metrics simplify complex systems, and trade-offs between simplicity, scope, and usability introduce unavoidable limitations. We revisit the Ellen MacArthur Foundation’s Material Circularity Indicator (MCI) to identify opportunities for a more accurate, comprehensive, reliable measure of circularity. Although widely used and highly regarded, the MCI exhibits limitations and methodologic
INTRODUCTION: While the characteristics and medical management of patients treated with long-term oxygen therapy (LTOT) have transformed during the last decades, the evidence base for LTOT itself remains largely unchanged. This study aimed to compare the risk of hospitalization and death among hypoxemic patients discontinuing LTOT, with that of controls continuing therapy.METHODS: This was a retro
Glucuronidation is the major phase II biotransformation reaction that facilitates the clearance of exogenous compounds from the human body. Glucuronidated metabolites have been investigated in urine samples at a broad scale; however, their characterization in other human biospecimens is underexplored. Our study has now performed a comprehensive profiling of glucuronides in plasma, fecal, and cereb
Background: Peritoneal recurrence (PREC) following nephrectomy for localized renal cancer (RCC) is rare. Our objective was to report a multicenter analysis of PREC to analyze incidence, treatment, survival and risk factors. Methods: Between 1987 and 2023, patients with PREC following radical or partial nephrectomy (PN) for localized RCC across ten European institutions (UroCCR, NKI, IRCCS, Foch an
Speaking in poor acoustic conditions constitutes a risk factor for voice disorders. This study investigated how speaker’s comfort and vocal effort were affected during short speech tasks in four different room acoustic configurations. Voice recordings of the speech tasks and self-evaluations of the speaker’s comfort were collected from 15 participants in four room acoustic configurations as part o
Scope: Vascular graft or endograft infection (VGEI) is a severe complication requiring a multidisciplinary approach combining surgery and antimicrobial therapy. This study aimed to develop expert consensus on the management and follow-up of VGEI, with a focus on antimicrobial strategies. Methods: A modified Delphi method was conducted to reach consensus on key aspects of VGEI care, including antim
Aging is the primary risk factor for most neurodegenerative diseases, yet the cell-type-specific progression of brain aging remains poorly understood. Here, human cell-type-specific transcriptomic aging clocks are developed using high-quality single-nucleus RNA sequencing data from post mortem human prefrontal cortex tissue of 31 donors aged 18–94 years, encompassing 73,941 high-quality nuclei. Di
Tuning the spectral and directional characteristics of thermal emission is critical for advancing technologies such as thermophotovoltaics (TPVs), passive thermal radiative cooling (PTRC), and solar thermophotovoltaics (STPVs), yet scalable fabrication methods remain limited. Here, femtosecond laser surface processing (FLSP), a top-down ablation and re-solidification approach is employed, to creat
This paper presents a single-layer filtering antenna (filtenna) based on a compact square substrate-integrated waveguide (SIW) cavity for millimeter-wave (mmWave) applications. The cavity operates in the fundamental TE110 mode to enable beam scanning, while a central shorting via introduces the TE210 mode, broadening the bandwidth. A radiating slot, placed at high-intensity regions of both modes,
BACKGROUND: Respiratory viruses, such as influenza viruses and SARS-CoV-2, cause severe infections of the respiratory system. Cohort studies and clinical observations indicate that patients with severe influenza A virus (IAV) infections are at an increased risk of developing an ischemic stroke event. However, the underlying mechanisms remain elusive. To this end, we investigated the consequences o
Abstract: The breast cancer long-term survival rate has improved; early detection of local recurrence and second primary cancers has been crucial to this success. Mammography is the standard imaging technique for follow-up, but its sensitivity is affected by breast density and post-treatment changes. This article discusses the role of mammography in the follow-up of women after breast cancer treat
Debattartikel: Forskningen krockar allt oftare med politiken. Sveriges forskare varnar nu för utvecklingen. Och deras oro är befogad.
The amyloid precursor protein intracellular domain (AICD), a cleavage product of amyloid precursor protein implicated in Alzheimer disease and amyloid lateral sclerosis, is a functionally important but structurally elusive intrinsically disordered protein. In this study, we investigate the conformational ensemble of a 35-residue AICD segment encompassing the conserved YENPTY motif using molecular
Recension av ”Filosoferna, del 4: Från filosofins födelse till den vetenskapliga revolutionen ca. 500 f.kr–1650”. Fri tanke.
Transport has a large impact on children’s lives from facilitating or limiting their mobility and access to destinations to impacting their health and wellbeing. However, cities have primarily focused on facilitating motor vehicle travel, which is an adult-exclusive mode. Likely, as a result, many children are escorted to places. In this chapter, we summarize literature on children’s travel from a
Elva visioner för Getteröverkets framtid skapade under en tvåveckors workshop med arkitektstudenter från Lunds universitet. Workshopen är en del av forskningsprojektet Transform som syftar till att utforska hur Getteröverket kan utvecklas från reningsverk till resursverk – vilka resurser kan vi ta tillvara, och hur?WorkshopenSyftet med workshopen var att identifiera på vilket sätt och för vem mark
This article presents a scoping and conceptual literature review on environmental politics in North and East Syria/Rojava. The review aims to synthesize existing academic research in English on the interplay between armed conflict and environmental change in the region, focusing on the Kurdish-led socio-political model known as the Autonomous Administration of North and East Syria (AANES). The stu
Background. Post-traumatic chondral and osteochondral lesions can be treated with autologous chondrocyte implantation (ACI), but the high cost of autologous cell expansion under strict Good Manufacturing Practice (GMP) regulations limits patient access. Stem cell–based advanced therapy medicinal products (ATMPs) offer more cost-effective alternatives, with human induced pluripotent stem cells (iPS
