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IMPORTANCE: No-touch saphenous vein harvesting preserves perivascular tissue and may improve graft patency after coronary artery bypass grafting (CABG), but whether it reduces long-term clinical events remains uncertain.OBJECTIVE: To compare 7-year clinical outcomes after no-touch vs conventional saphenous vein harvesting in patients undergoing CABG.DESIGN, SETTING, AND PARTICIPANTS: This is a pre
Background: Establishment of an organized, risk-adapted prostate cancer screening program in Germany could serve as a key entry point for preventive men’s health. Objectives: How can the introduction of an organized, risk-adapted prostate cancer screening program in Germany shape preventive urology of the future? Materials and methods: This narrative review article is based on guidelines and exper
Background: The EU4Health project PCM4EU aimed to improve survival rates and quality of life of patients with cancer based on precision cancer medicine. To achieve this, enhanced expertise and quality of molecular cancer diagnostics are key. Clinical decision support systems (CDSS) have become increasingly important after the introduction of comprehensive genomic diagnostic profiling. While extern
There has been an increased interest in utilizing gas turbine facilities with batteries due to continued increase in intermittent energy source production. Gas turbine-battery combination is able to cover the different categories of frequency containment reserve. One issue with operating gas turbines in the frequency reserve is their low efficiency, amounting to ∼30% for small engines. Thus, 70% o
Cyclic peptides are promising modalities for targeting intracellular sites; however, cell-membrane permeability remains a key bottleneck, exacerbated by limited public data and the need for well-calibrated uncertainty. Instead of relying on data-eager complex deep learning architecture, we propose a monomer-aware decoupled global alignment kernel (MD-GAK), which couples chemically meaningful resid
Background: Child study satisfaction has rarely been assessed in longitudinal pediatric research. This study examined child and maternal study satisfaction among 10–15-year-old participants in The Environmental Determinants of Diabetes in the Young (TEDDY) study, an observational multinational (US, Finland, Germany, and Sweden) study of children at increased genetic risk for type 1 diabetes enroll
OBJECTIVES: This is a protocol for a Cochrane review (intervention). The objectives are as follows: The primary objective of this review is to evaluate the benefits and harms of a subanaesthetic dosage of ketamine/esketamine as an adjunct to perioperative analgesia versus standard analgesia or placebo for reducing postoperative pain in participants undergoing gynaecological surgical procedures. A
The specific circumstances under which autism spectrum disorder could meet the legal standards severe mental disorder (SMD; the core Swedish legal concept underpinning sentencing to forensic psychiatric care) in criminal court cases are unclear. Aim To explore which neurocognitive and contextual factors that have been emphasized in the assessment of SMD in cases of autism spectrum disorder. Method
The aetiology of type 1 diabetes is not understood. Our new hypothesis suggests that the aetiology is related to a low beta cell mass at birth. Beta cells may be stressed by increased insulin demands related to accelerated growth, puberty, pregnancy, infections and other conditions. Resulting beta-cell necrosis induced by the metabolic stress is the pathogenesis. This will be detrimental to indivi
Sensitive detection of biomolecules in complex, non-transparent biological media is highly desirable for diagnostics and food safety. Semiconductor nanowires (NW) strongly amplify fluorescence signals, however their application has been largely limited to transparent media due to the scattering and absorption arising in turbid sample matrices. We present a detection platform based on polymer-suppo
Artificial light at night (ALAN) alters nocturnal ecosystems through both intensity and spectrum, yet routine mapping of ecologically relevant light fields at scales appropriate for management decision making remains elusive. We present LumiMaSAM, a probabilistic indicator that translates aerial night-time Red, Green, and Blue (RGB) imagery and Light Detection and Ranging (LiDAR) derived structure
X-ray ptychographic tomography enables quantitative 3D imaging at nanometer resolution, but the limited depth of field causes out-of-focus artifacts in 2D reconstructions of extended samples, restricting the range of projection angles and reducing the quality of the reconstructed volume. Here, we present an imaging-plane-optimized ptychographic tomography method that corrects out-of-focus artefact
The influence of scandium on the optical and luminescence properties of yttrium and gadolinium garnets is investigated. It is shown that the optical bandgap increases when (i) Ga is substituted by Al/Sc, (ii) Al is substituted by Sc, and (iii) Gd is substituted by Y cations. The modification of the electronic structure of the energy bands with Sc incorporation into yttrium garnets is shown in DFT
Background: Problematic gaming and broader digital media-related family difficulties are increasingly encountered not only in specialist mental health services but also in everyday municipal support services. Sweden’s new Social Services Act strengthens municipalities’ responsibility to provide early, accessible, and knowledge-based support, creating both an opportunity and an obligation to evalua
We study the geometric significance of Leinster’s notion of magnitude for a smooth manifold with boundary of arbitrary dimension, motivated by open questions for the unit disk in ℝ^2. For a large class of distance functions, including embedded submanifolds of Euclidean space and Riemannian manifolds satisfying a technical condition, we show that the magnitude function is well defined for R≫ 0 and
Background: In coproduced research, competing priorities among researchers and partners often surface as the work progresses, making such processes rarely tension-free. Although coproduction approaches are increasingly used in mental health research, there is limited understanding of how tensions are managed and how this influences collaboration. Hence, the aim of the study is to explore how tensi
Passings of heavy vehicles is a common cause of distress on thin and narrow cycle paths. The lack of lateral support at the edge and increased moisture content in the unbound granular materials are two important factors that affect deterioration. Three full-scale instrumented cycle path structures with different structural designs were constructed in a concrete pit at the Swedish National Road andPassings of heavy vehicles is a common cause of distress on thin and narrow cycle paths. The lack of lateral support at the edge and increased moisture content in the unbound granular materials are two important factors that affect deterioration. Three full-scale instrumented cycle path structures with different structural designs were constructed in a concrete pit at the Swedish National Road and
The first operational prototype of a high-purity germanium (HPGe) detector developed within the European LEAPS-INNOV project is presented in this work. This prototype features a monolithic, multi-element sensor optimized for high-resolution X-ray spectroscopy in the hard X-ray regime, intended for handing high count rates of 30 Mcps, across a broad energy range (5–100 keV). The present prototype d
With the increasing number of PV installations, reported PV-related fire incidents are receiving greater attention, although their quantification depends strongly on how such events are recorded. To manage fire safety risks in PV systems effectively, accurate statistics on the probability and consequences of these incidents are essential. National statistics from the UK, Italy, Sweden, and Sloveni
PurposeLong-term monitoring of crop biophysical and biochemical traits remains challenging in high-latitude regions due to short growing seasons, frequent cloud cover, and highly variable weather. In this context, unmanned aerial vehicles (UAVs) offer flexible, high-resolution observations, but their added value relative to low-cost proximal sensors and their effectiveness for radiative transfer m
