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Before a ligand is ready for commercial use as a drug, a long process of ligand optimization and understanding of the binding dynamics between the ligand and the drug target is required. One approach to tackling this is X-ray crystallography, which involves solving the structure of protein-ligand complexes. The information from the solved structures can be used to further optimize ligands until th
This master’s thesis explores the design of a construction toy that supports developmental play for children aged seven to ten years. The project is motivated by the observation that increasing digitalization and highly stimulating environments are changing the way children play, potentially reducing opportunities for tactile, open-ended, and self-directed play experiences that contribute to healt
We present a model dielectric function composed of critical point functions in order to parameterize the temperature and wavelength dependencies of the dielectric function of InAs. This model is based on Adachi’s critical point model, with simple wavelength-dependent analytical functions whose parameters change linearly with temperature. The calculated dielectric function at room temperature is in
Despite shrinking civic space, civil society organisations (CSOs) in Uganda continue to shape pathways toward sustainable and inclusive agricultural transformation. This paper explores why and how CSOs use non-confrontational strategies, particularly advocacy to influence policy and institutional processes regarding agricultural development. It draws on in-depth interviews with CSO actors, includi
This article elaborates on the notion of “decarbonisation by dispossession” in order to shed light on the contradictory character of capital-driven energy transitions. First, we suggest conceptualising “decarbonisation” as a “socio-ecological fix” to intersecting, climate-induced crises of accumulation and hegemony, aimed at saving capital rather than the planet. Second, reflecting on the mineral
This thesis consists of three essays in dynamic panel data econometrics. It studies the estimation of persistent dynamic relationships in panel models with unobserved heterogeneity and predetermined regressors, combining methodological contributions with an application in growth empirics.The first paper analyzes structural breaks in persistence in a dynamic panel first-order autoregressive model w
The Amazon has always been a strategic region because of its rich variety in natural resources. Its global interest is spreading across levels and scales, influenced by the increasing demand for fossil fuels and biodiesel and the threat of climate change. Neoliberal practices continue privatizing and exploiting the Amazon´s resources regardless the Indigenous communities’ interests. These communit
Digitalization is transforming the tax landscape, reshaping the operations of tax departments, authorities, and professionals. With rapid digital advancement, there has been a shift toward real-time reporting, e-invoicing, and greater reliance on digital data. This change is driven by investments in data analytics, robotic process automation, cloud platforms, and, more recently, artificial intelli
This paper describes measurements of the transverse momentum spectra of W and Z bosons produced in proton–proton collisions at centre-of-mass energies of s=5.02 TeV and s=13 TeV with the ATLAS experiment at the Large Hadron Collider. Measurements are performed in the electron and muon channels, W→ℓν and Z→ℓℓ (ℓ=e or μ), and for W events further separated by charge. The data were collected in 2017
A brain-computer interface (BCI) is a real-time system that converts a user’s brain activity into commands, enabling control over applications such as moving a cursor on the screen. This conversion is made possible by machine learning techniques and other algorithms. Historically, BCI research has focused on the analysis of brain signals offline. However, increasing computational power and algorit
There has been a growing interest in how workers in high-carbon industries are impacted by low-carbon transitions and how such transitions can be implemented in a way that is just. This study explores the socio-cultural dimensions of these processes, focusing on the role of identity in shaping workers’ perceptions of low-carbon transitions and their ability to navigate change. It does so through a
Lignin, a structurally intricate and heterogeneous phenolic biopolymer, holds considerable promise as a sustainable alternative to petrochemical-derived materials across diverse applications in the energy and materials sectors. However, precise lignin molecular weight and structure determination remains challenging due to its intrinsic tendency to aggregate in solution and the absence of chem
Issues of quality, value, and merit are perpetually lively and contentious in scientific and academic work, and research on evaluation panels have shown that organizational constraints and the methods of evaluation used, whether well-motivated or adopted ad hoc, have enormous influence on outcomes. But while previous studies have highlighted the influence exerted by particular methods of evaluatio
Understanding damage mechanisms and quantifying damage is important in order to optimise structures and to increase their reliability. To achieve this goal, experimental- and simulation-based techniques are to be combined. Different methods exist for the analysis of damage phenomena such as fracture mechanics, phase field models, cohesive zone formulations and continuum damage modelling. Assuming
Vietnam's increased integration into the global market economy entails rapid and dynamic changes that foster new ways of acting, interacting and rendering the world meaningful. This article addresses the ways in which an ongoing process of transformation in contemporary Vietnam is epitomised by the ambivalence and ambiguity with which female sexuality is imbued. Female sexuality is ideally restric
Axonal degeneration, which contributes to functional impairment in several disorders of the nervous system, is an important target for neuroprotection. Several individual factors and subcellular events have been implicated in axonal degeneration, but researchers have so far been unable to identify an integrative signaling pathway activating this self-destructive process. Through pharmacological an
Although border politics have been given much theoretical attention in recent years, empirical studies of identity construction among border police officers are less common. In 2014, a two-year collaborative project partly funded by the EU was initiated in order to increase international collaboration between border police officers in the Baltic Sea area. The participating organizations were borde
