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Popular Abstract in Swedish Många av alla kemiska processer som pågår i våra kroppar utförs av proteiner. När de inte fungerar blir vi sjuka. I vissa fall, till exempel vid Alzheimers sjukdom eller Creutzfeld Jacobs sjukdom, beror det på att ett visst protein har fel form. Att förstå hur proteiner antar sin slutliga form och vad det har för inverkan på proteinets funktion är således viktigt. ÅVery little is known about a considerable part of all proteins and it is time consuming and expensive to study each individual protein to determine its function, structure and cellular role. Proteins retain structural, functional and sequential characteristics from ancestral proteins and hence two proteins that share a common ancestor, i.e. are homologs, will to some extent have similar sequen

Popular Abstract in Swedish Bihåleinflammation (rinosinuit) definieras som inflammation av näsans och bihålornas slemhinna. Akut rinosinuit är den femte vanligaste orsaken till antibiotikaförskrivning. Kronisk rinosinuit verkar vara ett ökande hälsoproblem, som drabbar drygt 9% av Europas befolkning och innebär en stor belastning på hälsoekonomin. Amerikanska studier har visat att rinosinuit påverRhinosinusitis is defined as an inflammatory process involving the mucosa of the nose and one or more of the paranasal sinuses. The aims of the work presented in this thesis were to investigate the degree to which rhinosinusitis affects the health-related quality of life (HRQOL), and to determine whether the diagnosis of this condition can be improved using Doppler ultrasound. The HRQOL of 207 pa

Med avseende på de svenska förhållandena vintertid kan frostpåverkan antas ha betydande inverkan på nedbrytningen av betong i vattenbyggnader. Både ytliga och inre skador, vilka misstänks ha orsakats av frostpåverkan, har upptäckts på betong i exempelvis vattenkraftkonstruktioner. Nämnda observationer har väckt frågor om vattenbyggnaders beständighet i ett kallt klimat. Ytligt belägna skador, vilOwing to the winter conditions in Sweden, the effects of frost action may have a considerable impact on the deterioration of concrete. Both superficial and internal damage, which are suspected to have been caused by frost action, have been found in concrete in hydraulic structures. These observations have raised questions about the long-term behaviour of hydraulic structures in cold regions. Supe

The present thesis is devoted to two different matters: One part is the development of a novel optical technique for characterisation of solid pharmaceutical materials. The other part being the continued development of photon time-of-flight spectroscopy, as well as exploration of new application areas of this method. These two optical techniques are conceptually and technically very different, but

Autochthonous blockfield mantles may indicate alpine surfaces that have not been glacially eroded. These surfaces may therefore serve as markers against which to determine Quaternary erosion volumes in adjacent glacially eroded sectors. To explore these potential utilities, chemical weathering features, erosion rates, and regolith residence durations of mountain blockfields are investigated in the

ABSTRACT: BACKGROUND: The two-step dilute acid hydrolysis (DAH) of softwood is costly in energy demands and capital costs. However, it has the advantage that hydrolysis and subsequent removal of hemicellulose-derived sugars can be carried out under conditions of low severity, resulting in a reduction in the level of sugar degradation products during the more severe subsequent steps of cellulose hy

Popular Abstract in Swedish De senaste 150 åren har erbjudit en dramatisk utveckling av vår förmåga att sprida både njutningar och smärta, både i form av upptäckter av ämnen såsom TNT och dynamit och framställningen av heroin och Viagra. Denna utveckling har följts av teknologiska framsteg som tillåter studier av dessa kemikalier genom deras interaktion med till exempel radiosignaler eller laser. Modern spectroscopic techniques, such as nuclear quadrupole resonance (NQR), nuclear magnetic resonance (NMR), and Raman spectroscopy, rely heavily on statistical signal processing systems for decision making and information extraction. The first part of this thesis introduces novel robust algorithms for detection, estimation, and classification of signals obtained through these spectroscopic tech

Soil organic matter (SOM) stores the largest quantity of C in terrestrial ecosystems. Most SOM can be decomposed by microorganisms and released as CO2 into the atmosphere. The remaining fraction of SOM can be resistant against microbial decomposition over centuries to millennia. Changes in the magnitude of this stable SOM pool can have a substantial effect on the atmospheric CO2 concentration and

The objective of this article is to amalgamate previous results into a speculative synthesis that sheds light on the causes of secondary brain damage following either global/forebrain or focal ischemia. The hypothesis is based on the well-founded assumption that the pathophysiology of the brain damage incurred by global or forebrain ischemia is different from that of focal ischemia. In the former,

BACKGROUND: Diabetic kidney disease (DKD) remains one of the leading causes of premature death in diabetes. DKD is classified on albuminuria and reduced kidney function (estimated glomerular filtration rate (eGFR)) but these have modest value for predicting future renal status. There is an unmet need for biomarkers that can be used in clinical settings which also improve prediction of renal declin

Background: Apolipoprotein M (apoM) is a 25-kDa apolipoprotein present in 5% of high-density lipoprotein (HDL) particles. It is suggested to be anti-atherogenic and to play a key role in sustaining endothelial barrier integrity. SLE patients have increased cardiovascular disease risk, and we aimed to investigate if apoM levels reflect endothelial function in SLE. Since apoM plasma levels decrease

Heating the 50-electron cluster [Fe3(CO)9 (μ3-Te)2] (1) with the diphosphines Ph2P-R-PPh2 [R = -CH2CH2- (dppe), Z-CH=CH- (dppv), 1,2-C6H4 (dppb), -CH2CH2CH2- (dpp), ferrocenyl (dppf), naphthalenyl (dppbn)] in benzene affords the 52-electron diphosphine-containing tellurium-capped triiron clusters [Fe3(CO)8 (μ3-Te)2 (κ2-diphosphine)] (diphosphine = dppe, dppv, dppb, dpp, dppf, dppnd) (2–7) in moder

Context. At about 1000 days after the launch of Gaia we present the first Gaia data release, Gaia DR1, consisting of astrometry and photometry for over 1 billion sources brighter than magnitude 20.7. Aims. A summary of Gaia DR1 is presented along with illustrations of the scientific quality of the data, followed by a discussion of the limitations due to the preliminary nature of this release. Meth

Wohlers Associates, Inc., recognized widely as the leading consulting firm and preeminent authority on additive manufacturing and 3D printing worldwide—terms that are used interchangeably—today announced the publication of the Wohlers Report 2016. The 2016 edition marks the 21st consecutive year of its availability. According to Wohlers Report 2016, the additive manufacturing (AM) industry, consis

We present a novel method for monitoring isothermal lipid hydration using a sorption microcalorimeter. A measuring cell of the double-twin calorimeter consists of two vessels connected by a stainless steel tube. The upper vessel contains pure water, and the bottom vessel is loaded with the lipid sample. This calorimeter allows for simultaneous measurement of the partial molar enthalpy and the chem

This doctoral thesis is comprised of five parts which deal with different signal processing problems in ECG-based characterization of atrial arrhythmias. Such characterization requires that the ventricular activity has first been cancelled in the ECG. In Part I, a new method for cancellation of the QRST complexes in recordings with atrial fibrillation is presented. The method is based on a spatiot

Popular Abstract in Swedish Inledning Kreativitet kan definieras på många olika sätt. I denna avhandling definieras kreativitet som ”ett generativt eller produktivt nytt sätt att uppleva verkligheten och sig själv på”, vilket är en något modifierad version av Smith och Carlssons (1990) kreativitetsdefinition. Det produktiva sättet att se på verkligheten uppkommer just av att man kan rekonstruera Four studies on creativity, imagination and self-image in 10-year-old children constitute the basis of this dissertation. A total of 179 participants were involved. Study I investigated two new creativity measurements comprising The Drawing Task, which had its starting-point in a brief story, and The Activity Questionnaire, which included questions about the children’s spare time activities. The h

The demand for fast and energy efficient (opto-)electronic applications needs high mobility semiconductor materials, such as InAs with a very high electron mobility and GaSb with a very high hole mobility. Beyond the material itself, also an innovative device geometry is needed, for example, the gate-all-around geometry that provides higher efficiency and electrostatic control for computational un