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BACKGROUND: Lynch syndrome is a rare familial cancer syndrome caused by pathogenic variants in the mismatch repair genes MLH1, MSH2, MSH6, or PMS2, that cause predisposition to various cancers, predominantly colorectal and endometrial cancer. Data are emerging that pathogenic variants in mismatch repair genes increase the risk of early-onset aggressive prostate cancer. The IMPACT study is prospect

Elementary particles and their interactions are successfully described by the Standard Model of particle physics (SM). However, it has been observed that extensions Beyond the Standard Model (BSM) are required to account for a large part of yet undiscovered particles and interactions, such as Dark Matter (DM).To advance the knowledge of the SM and to pursue DM discoveries, CERN has the ambitious p

Meteorological investigations were carried out in forests in the southwestern part of the Swabian Alb (SW Germany) to analyze the influences of exposition and silvicultural treatment on the microchmate within various stands of beech (Fagus sylvatica L.). The measurements were taken as part of an interdisciplinary project on the effects of climate and forest management on structures and processes w

I denna forskningsöversikt kartläggs svenskproducerad och kvalitetsgranskad forskning om svensk forskarutbildning i syfte att illustrera forskningsfältets fysiska och vetenskapliga formering 2000–2020. Databasen Swepub användes för att identifiera licentiatavhandlingar, doktorsavhandlingar och refereegranskade artiklar som sedan analyserades med deskriptiv statistik och tematisk analys. Fältets fyIn this scoping review we map Swedish research on Swedish doctoral education in order to illustrate the physical and scientific configuration of the field from 2000 to 2020. The database Swepub was used to identify licentiate theses, doctoral theses, and peer reviewed articles. Subsequently the material was analysed through descriptive statistics and thematic analysis. The physical configuration o

In boreal summer, circumglobal Rossby waves can promote stagnating weather systems that favor extreme events like heat waves or droughts. Recent work showed that amplified Rossby wavenumber 5 and 7 show phase-locking behavior which can trigger simultaneous warm anomalies in different breadbasket regions in the Northern Hemisphere. These types of wave patterns thus pose a potential threat to human

Popular Abstract in Swedish Denna avhandling syftar till att belysa vilket professionskunnande som blivande lärare ges möjlighet att utveckla under sin högskoleförlagda utbildning och hur detta professionskunnande kan karaktäriseras. Detta belyses genom ett antal forskningsfrågor: Vilka olika undervisningspraktiker konstituerar den högskoleförlagda lärarutbildningen? På vilket sätt upprättas dessaThe starting point for this dissertation was the reform of the school system in Sweden with consequences for teachers´ work and new demands on their professional knowledge. This thesis aims to illuminate the issue of what professional knowledge student teachers are offered during their time in the university, and how this professional knowledge can be characterised. This is carried out with respec

Since the earliest economic historical studies wage series have been used to sketch economic development both at the macro and the household level. This dissertation takes advantage of new data from women and men, working in both the countryside and in towns, as well as employed both by the day and on long-term contracts, in order to make an in-depth quantitative look at the relationships between

Qinghai-Tibet Plateau grasslands are unique geographical regions and store substantial soil organic matter (SOM) in the soil surface, which make them very sensitive to global climate change. Here, we focused on three main grassland types (alpine meadow, steppe, and desert) and conducted a soil incubation experiment at five different temperatures (5, 10, 15, 20, and 25°C) to investigate SOM decompo

Compounds containing lone-pair elements such as TeIV are very interesting from the structural point of view, as the lone-pair nonbonding regions create low-dimensional geometrical arrangements. We have synthesized two new compounds with these features - Ba2Cu2Te 4O11Br2 (I) and Ba2Cu 2Te4O11-δ(OH)2δBr 2 (II, δ ≈ 0.57) - as members of the AE-M-Te-O-X (AE = alkaline-earth metal, M = transition metal

An experimental test system including the oil circulation system and the gas circuit system has been designed and built to explore the effects of the lubricating oil flow rate on the performance of a single-screw compressor, used in a portable natural gas liquefaction process. Outlet pressure, outlet volumetric flow rate, volumetric efficiency, and specific power rate are the parameters for evalua

Background: Listening effort seems to depend on input-related listening demands and several factors internal to the individual listener. Input-related demands may be listening in noise compared with listening in quiet, and internal factors may be cognitive functions. Purpose: The purpose was to apply measures of listening effort and perceived listening effort in participants with normal hearing, t

Macromolecular crowding in biological media is an essential factor for cellular function. The interplay of intermolecular interactions at multiple time and length scales governs a fine-tuned system of reaction and transport processes, including particularly protein diffusion as a limiting or driving factor. Using quasielastic neutron backscattering, we probe the protein self-diffusion in crowded a

Northeast China, the most important region for commercial grain farming in China, is vulnerable to drought due to high fluctuation in monthly rainfall. Timely, accurate and effective drought monitoring is very essential for securing the output of grain farming. In this study, three widely used drought indices were compared using satellite soil moisture data and their capability for drought monitor

This brief presents an on-chip memory subsystem for massive multiple-input-multiple-output (MIMO) baseband processing at the base station. In massive MIMO systems, the required memory bandwidth and capacity are orders of magnitude higher than those used in conventional wireless systems, due to the large number of serving antennas. These are further combined with design targets on low access latenc

There is a battle in the supermarket isle, a battle between what the consumer wants and what the retailer and others want her to see, and subsequently to buy. Product packages and displays contain a number of features and attributes tailored to catch consumers' attention. These are what we call external factors comprising the visual saliency, the number of facings, and the placement of each produc

Long-term selection (>45 generations) for low or high body weight from the same founder population has generated two extremely divergent lines of chickens, the low (LWS) and high weight (HWS) lines, which at the age of selection (56days) differs by more than nine-fold in body weight. The HWS line chickens are compulsive feeders, whereas, in the LWS line, some individuals are anorexic and others ha

High EGR rates combined with turbocharging has been identified as a promising way to increase the maximum load and efficiency of heavy duty spark ignition engines. With stoichiometric conditions a three way catalyst can be used which means that regulated emissions can be kept at very low levels. Obtaining reliable spark ignition is difficult however with high pressure and dilution. There will be aHigh EGR rates combined with turbocharging has been identified as a promising way to increase the maximum load and efficiency of heavy-duty spark ignition engines. With stoichiometric conditions a three-way catalyst can be used which means that regulated emissions can be kept at very low levels. Obtaining reliable spark ignition is difficult however with high pressure and dilution. There will be a

PURPOSE: Renal cell carcinoma (RCC) is derived from a tissue with a remarkable capacity for vectorial transport. We therefore performed an unbiased exploration of transporter proteins in normal kidney and kidney cancer in order to discover novel clinical targets.EXPERIMENTAL DESIGN: Using the TCGA database we investigated differences in membrane transporter expression in ccRCC and normal kidney. W