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Orphan drugs designed to treat rare diseases are often overpriced per patient. Novel treatments are sometimes even more expensive for patients with ultra-rare diseases, in part due to the limited number of patients. Pharmaceutical companies that develop a patented life-saving drug are in a position to charge a very high price, which, at best, may enable these companies to further develop drugs for
Purpose: The inappropriate irrigation is accelerating the soil salinization in western irrigation districts of China. The amelioration of salinized land must be based on large amount of water content and salinity data. Plastic coated TDR has been designed to measure water content accurately in highly saline soil, but the soil bulk electrical conductivity cannot be measured due to the coated materi
The energy hub concept is gradually getting popular due to its capability to integrate renewable energy technologies into the energy grid with a minimum impact. Designing distributed energy hubs is a challenging task due to the coupling of optimum dispatch and energy system sizing problems. Operation of the system needs to be considered for 8760 time steps and energy system sizing optimization can
Summary: Background: In 2014, the Swedish Association of Clinical Physiology recommended the use of a new reference material for exercise capacity in bicycle exercise stress testing, 'the Kalmar material'. Compared to the formerly used reference material, 'the Kristianstad material', an increase in the amount of patients being classified as having decreased exercise capacity was expected, but the
With the shift of focus of the regulatory bodies, from fixed process conditions towards flexible ones based on process understanding, model-based optimization is becoming an important tool for process development within the biopharmaceutical industry. In this paper, a multi-objective optimization study of separation of three insulin variants by reversed-phase chromatography (RPC) is presented. The
Cephalopods have very conspicuous eyes that are often compared to fish eyes. However, in contrast to many fish, the eyes of cephalopods possess mobile pupils. To increase the knowledge of pupillary and thus visual function in cephalopods, the dynamics of the pupil of one of the model species among cephalopods, the common octopus (Octopus vulgaris), was determined in this study. We measured pupilla
The Extended Evolutionary Synthesis (EES) is currently emerging as a theoretical alternative to the Modern Synthesis (MS) in which to frame evolutionary observations and interpretations. These alternative frameworks differ fundamentally in their understanding of the relative roles of the genotype, phenotype, development and environment in evolutionary processes and patterns. While the MS represent
The trajectories of politically activist and socially committed interpretations of Islam in (late)modern societies continue to spur heated debate and academic discussion. A recurrent theme is the compatibility of Islamic ideological/legal foundations vis-à-vis secular state institutions and liberal democracy. Other debates concern rights and identity politics, problematizing the recognition of relThe trajectories of politically activist and socially committed interpretations of Islam in (late)modern societies continue to spur heated debate and academic discussion. A recurrent theme is the compatibility of Islamic ideological/legal foundations vis-à-vis secular state institutions and liberal democracy. Other debates concern rights and identity politics, problematizing the recognition of rel
Animal bedding, a mixture of straw and manure, could be used as a feedstock for bioenergy production, but its heterogeneity poses new challenges in its use in biorefineries. We have investigated the origin of this heterogeneity and quantified it, and discuss its impact on bioenergy production. Samples were collected from the bedding at different points and depths and analysed by first separating t
Drainage networks are the basis for segmentation of watersheds, an essential component in hydrological modelling, biogeochemical applications, and resource management plans. With the rapidly increasing availability of topographic information as digital elevation models (DEMs), there have been many studies on DEM-based drainage network extraction algorithms. Most of traditional drainage network ext
An experiment was conducted at the GANIL/LISE3 facility to produce the 10+ isomer of 54Ni and measure its proton radioactivity decay branches. The proton detection was achieved with the ACTAR TPC device that enabled the separation of the small signal of the emitted proton from the large signal of the implanted ion, while the decay half-life is of the order of 150 ns. From the measured data, the em
A feasible implementation of a novel X-ray detector for highly energetic X-ray photons with a large solid angle coverage, optimal for the detection of Compton X-ray scattered photons, is described. The device consists of a 20 cm-thick sensitive volume filled with xenon at atmospheric pressure. When the Compton-scattered photons interact with the xenon, the released photoelectrons create clouds of
Background: Pain is associated with falls, disability and a poor quality of life among older adults. It is highly prevalent in many societies, and studies have shown that pain could be preventable or managed more effectively at the population level. However, few studies have investigated who is at higher risk of pain in the general population, which is important for development of effective interv
A search is presented for the production of a single top quark via left-handed flavour-changing neutral-current (FCNC) interactions of a top quark, a gluon and an up or charm quark. Two production processes are considered: u+ g→ t and c+ g→ t. The analysis is based on proton–proton collision data taken at a centre-of-mass energy of 13 TeV with the ATLAS detector at the LHC. The data set correspond
