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Antipsychotic drugs (APD) are commonly prescribed to people living with dementia (PwD) to manage behavioral and psychological symptoms of dementia (BPSD), despite well-documented safety concerns. International guidelines recommend non-pharmacological interventions as first-line treatment, yet APDs remain widely used. This systematic review and meta-analysis synthesize current evidence on the conse
Abstract INTRODUCTION Countries have varying, limited healthcare budgets for emerging disease-modifying therapies. Cost-effectiveness analysis, combined with country-level cost-effectiveness thresholds, can be used to estimate value-based prices (VBPs) for lecanemab and donanemab across 174 countries. METHODS The cost-effectiveness of lecanemab and donanemab was estimated using incremental cost an
Standardized Care Pathway (SCP) for patients presenting with macroscopic haematuria was introduced in Sweden in 2015. In contrast to neighbouring countries, the Swedish model includes all patients with macroscopic haematuria above the age of 50, notwithstanding obvious causes. The aim of this study was to characterize the patients referred within the SCP and the presence of acute cystitis.All pati
Postural orthostatic tachycardia syndrome (POTS) as conventionally defined is a chronic condition (typically >3 months duration) incorporating reproducible symptoms of orthostatic intolerance (including dizziness/lightheadedness, and near-syncope) in the absence of orthostatic hypotension (i.e., absence of a sustained systolic blood pressure drop >20mmHg with upright posture). 1-10 More recently
Background: Children and adolescents with autism spectrum disorder (ASD) are generally more sedentary and engage less in physical activity (PA) than their peers. Despite increasing evidence of benefits, practical guidance on implementing adapted PA programs in real-world settings remains limited. This study aimed to document iterative adaptations, implementation processes, and participant experi
Cross-border integration between Greece, Turkey and Bulgaria has been recently dominated by traditional perception of political diplomacy that overrides the considerations for economic cooperation. This project suggests that more in-depth case analysis of the Evros-Maritza-Meric Euroregion will elucidate the evolution of this concept. The existence of long-term barriers in the cross-border region
Key words: Corporate environmentalism, ecologic-economic decision-making, CSR worldviews Purpose: To explore environmental decision-aming processes at managers at Skanska, also with regard to enviornmental decison-making conceptualizations in theory. Method: The research of the thesis is based on a qualitative approach through the use of semi-structured and open interviews. Furthermore an interpre
"The technology for planning and delivering radiotherapy has in the last decade undergone some revolutionary development and it is now possible to perform complex treatments such as stereotactic treatments and treatments using dynamic wedges, multileaf collimator and intensity modulation. The more precise limits surrounding the PTV have made it of utmost interest to be able to verify calculat
Climate change has emerged as the most prominent of the global environment issues and there is a need to evaluate its impact on the agriculture. General Circulation Models (GCMs) which are considered as the most advance tools for estimating future climate change scenarios operate on coarse resolutions. It is for this reason the climate change model MAGICC coupled to SCENGEN developed by the IPCC w
The aims of the present study were to implement and evaluate a three-session Acceptance and Commitment Therapy (ACT) stress management intervention in a non-clinical group of university students (N = 25) and to investigate the importance of practice in an ACT-intervention. A design with pre-test and double post-test was chosen. A comparison was made between a nine-hour ACT-intervention containing
The study tries to look at the impact of microfinance on the lives of the extreme poor people. There are different views on microcredit/microfinance as a powerful development tool regarding its success in developing the lives of the extreme poor and sometimes these views are contradictory. The purpose of the study was to observe the social and financial changes that have occurred also with an effo
Children with hemophilia have a significantly higher risk of intracranial hemorrhage (ICH) compared to the normal population. Prophylaxis reduces the risk of ICH and earlier initiation of prophylaxis may now be feasible, especially in hemophilia A (HA). The aim of the study is to explore the potential for preventing ICH by earlier start of prophylaxis by assessing the natural course of ICH before
In contemporary enterprises, customer satisfaction analysis has become a critical area of concentration. Being able to understand and predict customer satisfaction is becoming more and more important as companies try to develop and launch new products. Leveraging customer data intelligently and employing robust data analytics techniques are essential for meeting this imperative. With this objectiv
Plasma p-tau217 and tau positron emission tomography (PET) are strong prognostic biomarkers in Alzheimer’s disease (AD), but their relative performance in predicting future cognitive decline among cognitively unimpaired (CU) individuals is unclear. In a head-to-head comparison study including nine cohorts and 1,474 individuals, we show that plasma p-tau217 and medial temporal lobe tau-PET signal d
This paper presents a low-profile, single-layer, broadband, polarization-reconfigurable metasurface antenna with a low radar cross section (RCS). The design leverages characteristic mode analysis (CMA) applied to a staggered elliptical-shaped unit cell metasurface. The unique arrangement of the elliptical-shaped elements, oriented at 90°, promotes mode fusion through CMA, effectively reducing RCS.
Background: In this study, we further developed an artificial intelligence (AI)-based method for the detection and quantification of tumours in the prostate, lymph nodes and bone in prostate-specific membrane antigen (PSMA)-targeting positron emission tomography with computed tomography (PET–CT) images. Methods: A total of 1064 [18F]PSMA-1007 PET–CT scans were used (approximately twice as many com
BACKGROUND: Balloon-guide catheters (BGC) have been associated with improved procedural and functional outcomes following endovascular thrombectomy (EVT) in multiple observational studies. Recently the PROTECT-MT trial challenged this benefit, showing worse functional outcomes when using BGCs. This study aims to assess the association between BGC-use and procedural and functional outcomes in a lar
This paper presents a novel convolutional neural network (CNN)-based control chart for detecting localized and subtle speckle shifts (displacements) in the images. To enhance detection accuracy, especially in detecting localized and simultaneous shifts, we design a custom CNN architecture and utilize a training methodology. Moreover, instead of inputting the entire images, we divide them into equa
