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Importance: Despite some promising preclinical and clinical data, it remains uncertain whether remote ischemic conditioning (RIC) with transient cycles of limb ischemia and reperfusion is an effective treatment for acute stroke. Objective: To evaluate the effect of RIC when initiated in the prehospital setting and continued in the hospital on functional outcome in patients with acute stroke. Desig
Background: Despite improvements in hemophilia care, challenges remain, including treatment burden and impaired quality of life. Gene therapy may overcome these. However, its introduction presents a challenge. Objectives: To outline a function-based gene therapy working model describing critical milestones associated with gene therapy handling, administration, and follow-up to facilitate and imple
Denna uppsats beskriver nödvärnsrätten och möjligheten till att använda vapen i motvåld. Genom en rättsdogmatisk metod undersöker jag nödvärnsrätten, polisers vålds- och vapenanvändning och slutligen avgöranden där enskilda och polismän agerat i nödvärn med vapen. En medborgare i en rättsstat får inte ta rätten i sina egna händer. Vid ett brottsligt angrepp har dock enskilda och polismän rätt til
Korruption är ett stort samhällsproblem och offentlig upphandling är ett särskilt utsatt rättsområde när det gäller korruption. Offentlig upphandling rör stora värden i organisationer där det arbetar en mängd människor som på ett eller annat vis kan vara mer frestade att ta emot någon form av belöning eller av ren okunskap bidrar till korruption. Det är inte alltid lätt att veta var gränsen för deCorruption is an immense problem in our society and public procurement is a judicial area, which is especially vulnerable for corruption. Public procurement contains large amounts of money in organizations where the mass of employed in one or another way may be more tempted to accept some kind of remuneration or of pure ignorance contributes to corruption. It is not always easy to know where the l
I svensk rätt saknas en lagstadgad bestämmelse som ger vårdpersonal rätt att vägra arbeta med aborter, s.k. samvetsfrihet. Avsaknaden av en sådan rätt har föranlett att en barnmorska som vägrar medverka vid aborter nekats tre anställningar av Jönköpings landsting. Barnmorskan, som heter Ellinor Grimmark, menar att hon diskriminerats på grund av religion, något som diskrimineringsombudsmannen, DO,
De nationella domstolarna intar en central roll i den Europeiska unionens judiciella system men är inte helt fria att på egen hand bedöma unionsrättsliga frågor. I denna uppsats undersöks hur utrymmet för nationella domstolar till självständiga unionsrättsliga bedömningar begränsas av den skyldighet att begära förhandsavgörande som kan följa av artikel 267 i Fördraget om Europeiska unionens funktiNational courts occupy a central role in the judicial system of the European Union, but they are not completely free to apply Union law independently. This paper examines the extent to which the national courts are limited by an obligation to request a preliminary ruling under Article 267 of the Treaty on the Functioning of the European Union, when it comes to assessing questions of EU law indepen
The purpose of the EANM Dosimetry Committee is to provide recommendations and guidance to scientists and clinicians on patient-specific dosimetry. Radiopharmaceuticals labelled with lutetium-177 (177Lu) are increasingly used for therapeutic applications, in particular for the treatment of metastatic neuroendocrine tumours using ligands for somatostatin receptors and prostate adenocarcinoma with sm
Aims: Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVC) is characterized by ventricular arrhythmias (VAs) and sudden cardiac death (SCD). We aimed to develop a model for individualized prediction of incident VA/SCD in ARVC patients. Methods and results: Five hundred and twenty-eight patients with a definite diagnosis and no history of sustained VAs/SCD at baseline, aged 38.2 ± 15.5
We present a new world-coordinate tracking algorithm for road users seen from static surveillance cameras, denoted GUTS. It is based upon the previously published UTS method but simplifies and replaces parts allowing association logic to work in world coordinates, by using a novel convolutional neural network denoted SAMHNet to convert every detection into world coordinates. Experimental evaluatio
BACKGROUND: KRAS mutation can alter the treatment plan after resection of colorectal cancer. Despite its importance, the KRAS status of several patients remains unchecked because of the high cost and limited resources. This study developed a deep neural network (DNN) to predict the KRAS genotype using hematoxylin and eosin (H&E)-stained histopathological images. STUDY DESIGN: Three DNNs were c
In this study, sorption distribution coefficients were determined for 71 pharmaceuticals, aiming to describe their sorption behavior to powder activated carbon (PAC). The data are expected to be applied when designing and upgrading wastewater treatment plants (WWTP) for improved removal of pharmaceuticals by applying sorption to PAC as an additional removal technique. Sorption isotherms were deter
The discovery of driver mutations is one of the key motivations for cancer genome sequencing. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumour types, we describe DriverPower, a software package that uses mutational burden and functional impact evidence to identify driver mutation
The steel industry is a major contributor to emissions of CO2 and key air pollutants. Reducing air pollution has since long been a policy priority in China. Reducing CO2 emissions has more recently also become a key priority partially manifested through the signing of the Paris Agreement in 2015. Although there are often synergies between reducing CO2 emissions and air pollution, it may have impli
I was invited to make a program for cola bora dio about my work with this project by sound and radio artist Kate Donovan, on her regular program Elements, in 2019. This is a recording of the live broadcast of that program. Cola bora dio is a low-power FM and online broadcast based in Berlin, with re-broadcasts and collaborations with other small-scale independent radio stations and artists worldwi
Context: Effective industry-academia collaboration may increase software engineering research relevance by increased realism, yet very challenging for reasons like confidentiality concerns, different objectives and priorities. Objective: We analyse industry-academia collaboration scenarios based on our own experiences as Ph.D. student and supervisor, and provide insights and recommendations to fac
Denna uppsats har kommit till som en följd av en självupplevd skada under värnpliktstjänstgöring vid F 21 SE/ÖN under januari månad 1989. Uppsatsen behandlar de värnpliktigas ersättningsmässiga situation vid personskador specifikt men redogör även för en stor del av den generella ersättningssituationen vid arbetsskador på vanliga förvärvsarbetande. Sistnämnda för att man ska kunna bilda sig en upp
Denna uppsats syftar till att belysa brotten eget bruk av narkotika samt innehav för eget bruk av narkotika. Detta leder i praktiken till att det blir den lindrigaste formen av narkotikabrott, ringa narkotikabrott, som belyses. För att lägga en grund till hela arbetet inleds det med en genomgång av den defensiva och den offensiva straffrättsmodellen. Den defensiva modellen förespråkar långtgående
From a continental point of view the Swedish regulation concerning the freedom of the press may appear rather peculiar, since a considerable number of the detailed rules is found at the highest level of the national hierarchy of legal rules - i.e. Grundlagen. In foreign legal systems the freedom of the press is normally stipulated in a very concise way in the constitutional act while the rules reg
