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Pancreatic islet hormone secretion is central in the maintenance of blood glucose homeostasis. During development of hyperglycaemia, the β-cell is under pressure to release more insulin to compensate for increased insulin resistance. Failure of the β-cells to secrete enough insulin results in type 2 diabetes (T2D). MicroRNAs (miRNAs) are short non-coding RNA molecules suitable for rapid regulation

ERP systems became popular with large organizations in the 1990s. In the 21st Century, these products were expanded by addition of supply chain management (SCM) and customer relationship management (CRM), as well as access through the Web, creating the ERP II concept. Efforts to increase the market led vendors to serve not only large organizations, but also focus more on small-to-medium sized ente

Spider silks combine basic amino acids into strong and versatile fibers where the quality of the elastomer is attributed to the interaction of highly adapted protein motifs with a complex spinning process. The evaluation, however, of the interaction has remained elusive. Here, we present a novel analysis to study silk formation by examining the secondary structures of silk proteins in solution. Us

Background: Block-sequential regularized expectation maximization (BSREM), commercially Q. Clear (GE Healthcare, Milwaukee, WI, USA), is a reconstruction algorithm that allows for a fully convergent iterative reconstruction leading to higher image contrast compared to conventional reconstruction algorithms, while also limiting noise. The noise penalization factor β controls the trade-off between n

Prostate cancer bone metastasis is still not fully understood, and increased knowledge could aid in the development of better treatment options for patients in the future. This thesis focuses on microRNAs (miRNAs), which modulate gene expression in healthy and tumour cells. Using cell culture, animal and patient studies, we investigated the biological role of microRNA-96 (miR-96) and microRNA-379

The purpose of this article is to contribute to a refined perspective on how the practices of everyday life can challenge existing spatial scale relations, as well as produce new ones, and how this in turn can be addressed by planning. The investigation is based on a discussion of empirical studies dealing with the role of migrants in processes of place-making and urban transformation. In the arti

The MM500 meta-study aims to establish a knowledge basis of the tumor proteome to serve as a complement to genome and transcriptome studies. Somatic mutations and their effect on the transcriptome have been extensively characterized in melanoma. However, the effects of these genetic changes on the proteomic landscape and the impact on cellular processes in melanoma remain poorly understood. In thi

Existing LLM-based approaches remain limited by simplistic task execution, restricted tool integration, and a lack of contextual reasoning when interacting with professional GIS software. This study investigates the efficacy of a multi-agent architecture designed to enhance geospatial task execution accuracy through collaboration, reasoning and tool-use. The architecture integrates Chain of Though

A random planar quadrangulation process is introduced as an approximation for certain cellular automata in terms of random growth of lines, called rays, from a given set of points. This model turns out to be a particular (rectangular) case of the well-known Gilbert tessellation, which originally models the growth of needle-shaped crystals from the initial random points with a Poisson distribution

Knowledge is today considered to be a critical factor for organisations to survive within an increasingly competitive market. This has resulted in the fact that effective management of information and knowledge has become of crucial importance for companies. Knowledge management systems facilitate this management of knowledge and make it possible to develop new knowledge that can be shared and dis

This paper is very much inspired by an ongoing process in the Swedish court system. According to Unibet, an online betting company, the Swedish law on lotteries conflicts with EC law. Therefore, Unibet has brought an action against the Swedish state seeking, firstly, a declaration that it has the right, pursuant to Article 49 EC, to promote its gaming and betting services in Sweden and is not prev

BACKGROUND: Ecuador is a Spanish speaking country located in northwestern South America with an approximate population of 16 million people. It is considered a developing country. The public healthcare system is divided into three branches and there are also private services available. Musculoskeletal disorders are overly represented in the developing world, especially where poverty and rural livi

Being stateless, roughly means being without a citizenship of any nation. This is the definition of being stateless in legal terms, called de jure statelessness. There is also statelessness that entails being without the efficient protection of one’s nation, called de facto statelessness. Two groups of stateless migrants that correspond to these definitions are Bidoons from Kuwait and Palestinians

Uppsatsen syftar till att diskutera om miljöbalkens målsättning är miljömässigt godtagbar. Frågeställningen är om innebörden av en hållbar utveckling utifrån den utveckling av begreppet som sker i relation till forskningen om planetära gränsvärden kan sägas vara inom ramen för målsättningen om hållbar utveckling i miljöbalkens portalparagraf. Först presenteras rättsvetarna Kim och Bosselmanns syThe purpose of this essay is to discuss if the objective of the Swedish Environmental Code (EC) is environmentally acceptable. The question asked is if the meaning of a sustainable development according to the development of the concept that is occurring in relation to research about planetary boundaries is within the scope of the objective of sustainable development in the preamble of the EC. At

This thesis studies how Sweden’s state identity is constructed within the discourse on Swedish Migration Policy following the European refugee crisis in 2015. Identity is studied by seeing the constructions of identity and policy as discursively interlinked and by using the notion of processes of linking and differentiation. The material analyzed are statements made by the Swedish government in or

Through recent years, RNA has rapidly gone from mainly being known as a passive information-carrying molecule within the central dogma of molecular biology to becoming the active ingredient in multiple therapeutics, such as in vaccines and potential drugs against cancer. However, one of the main challenges with RNA as a therapeutic is efficient delivery to cells. Understanding the mechanism throug

I Sverige avlider över tusen personer varje år till följd av en fallskada och cirka 70 000 personer skadas såpass allvarligt att de behöver vård. Fallolyckor kostar Sverige 11.1 miljarder kronor per år och är en av de största utmaningarna för sjukvården och äldreomsorgen idag. Då risken att råka ut för en fallskada ökar med ålder samt att en stor del av befolkningen i Sverige beräknas nå pensionsåMore than a thousand people die each year in Sweden due to fall injuries and approximately 70,000 people injures themselves so seriously that they need care. Falling accidents cost Sweden 11.1 billion SEK a year and is one of the biggest challenges for healthcare and elderly care today. Since the risk of fall injuries increase with age and a large part of the population in Sweden is expected to re