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During bacterial infections at mucosal sites, neutrophils migrate to the mucosa and cross the epithelial barrier. We have examined neutrophil migration across Escherichia coli-stimulated uroepithelial cell layers in an attempt to more fully understand this process. Stimulation of uroepithelial cells with E. coli or interleukin-1α (IL-1α) induced transepithelial neutrophil migration in a time- and
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The aim of this study was to describe the performance of a closed loop interstitial laser thermotherapy system in processed liver and to demonstrate its suitability for treating a vascularized tumour in vivo. The thermotherapy system consisted of an Nd:YAG laser and a temperature feedback circuit including an automatic thermometry system and thermistor probes. Experiments in processed liver were p
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Road agencies set quantitative targets and adopt related road safety strategics in accordance with each agency's priorities and available resources. Benefit-cost analyses are carried out to support the decision-making process, and alternative measures are ranked according to their expected benefits and benefit-cost ratios, calculated with a safety performance function (SPF) and crash modification
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Laser-induced fluorescence (LIF) has been developed for visualization of fuel distribution fields in an operating spark-ignition (SI) engine. Since the standard research fuel iso-octane, does not yield a useful LIF signal a fluorescent additive was used. None of the commonly used seeds were found adequate. A seed not commonly used in this context, 3-pentanone, C2H5COC2H5, was chosen due to favorab
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It is speculated that virtual environments (VE) might be used as a training tool in brain injury rehabilitation. The rehabilitation process often involves practicing so-called instrumental activities of daily living (IADL), such as shopping, cooking, and using a telephone. If a brain injury patient is to practice such activities in a VE, the patient must be able to navigate the viewpoint and inter
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This thesis deals with the modeling of anisotropic materials at finite deformations. The major emphasis is the development of constitutive models able to account for the evolving directionally dependent properties of these materials. In addition, the numerical implementation of the models developed is addressed. In particular, the following topics are considered. To model finite elasto-plastic de
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Fossil fuel subsidies continue to be a considerable barrier to meeting the targets of the Paris Agreement. It is thus crucial to understand the political economy of fossil fuel subsidies and their reform. To understand these mechanisms in the developed world, we use a database of different types of fossil fuel subsidy reforms among Organisation for Economic Co-operation and Development (OECD) coun
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Precision medicine should aspire to reduce error and improve accuracy in medical and health recommendations by comparison with contemporary practice, while maintaining safety and cost-effectiveness. The etiology, clinical manifestation and prognosis of diseases such as obesity, diabetes, cardiovascular disease, kidney disease and fatty liver disease are heterogeneous. Without standardized reportin
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Background and objective: Laboratories sometimes use different reference ranges for the same antiepileptic drug (AED), particularly for new and poorly investigated drugs. This may contribute to misunderstandings, concerns or inappropriate dose changes, which in turn may affect therapeutic effect, drug safety or treatment adherence. Therefore, the Norwegian Association of Clinical Pharmacology wish
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Froth flotation is a common unit operation used in mineral processing. It serves to separate valuable mineral particles from worthless gangue particles in finely ground ores. The valuable mineral particles are hydrophobic and attach to bubbles of air injected into the pulp. This creates bubble-particle aggregates that rise to the top of the flotation column where they accumulate to a froth or foam
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Supply chains are difficult to plan because they involve complex relationships that influence supply chain performance. In this paper, discrete-event simulation (DES) is discussed in order to identify if it could be a technique used to improve supply chain planning. Two DES models have been developed and are used in this paper to find out whether DES could be a technique for unraveling the complex
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The number of devices connected to the Internet grows constantly. This information entity has been labeled the Internet of Things (IoT). One important aspect of this is the industrial applications, sometimes labeled the Industrial Internet of Things (IIoT). Collecting and analyzing the massive amounts of data that industry generates will only become more and more important as technology and the ne
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Europakonventionen är en internationell konvention som ämnar säkerställa vissa mänskliga rättigheter. De anslutna staterna åtar sig att garantera var och en inom deras jurisdiktion de fri- och rättigheter som stadgas i konventionen. Sverige har undertecknat och ratificerat konventionen. Om staten överträder sina konventions-åtaganden kan denna fällas till ansvar av den övervakande Europadomstolen.The European Convention on Human Rights is an international convention aiming to assure certain human rights. The affiliated states undertake to guarantee each and everyone within their jurisdiction the freedoms and rights enacted in the Convention. Sweden has signed and ratified the Convention. Should the state transgress its undertakings it can be held responsible for the breach by the superviso
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Syfte: Studiens syfte är att undersöka hur pensionerade lärare som undervisat på låg- och mellanstadiet upplever och beskriver sin tillvaro. Deltagarnas upplevelser av övergången från arbete till pension, identiteten som pensionär samt möjligheter och svårigheter under pensionärslivet och hantering av dessa undersöks. Metod: Studien är fenomenologisk. Semistrukturerade intervjuer genomfördes med fPurpose: The purpose of this study is to explore how retired teachers, who had worked in a primary school setting, experience and describe their lives. The study investigates the transition from working to retired life, retiree identity and possibilities and difficulties in the retired life. Method: The study has a phenomenological approach. Semi-structured interviews were conducted with five part
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Female-limited colour polymorphisms provide interesting examples of intraspecific genetic diversity but, in most polymorphic taxa, we know little about the macroevolutionary origin and subsequent history of polymorphism during diversification. The damselfly genus Ischnura includes many species with multiple, heritable female colour morphs. The evolutionary origin of polymorphism in this clade is u
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Asset prices have had larger and more rapid increases since 1980 when compared to the post-war period, especially compared to the Bretton Woods period. In this thesis we test whether the excess elasticity view provides a plausible explanation for this change. The excess elasticity view, put forth by Borio and Disyatat (2011) and Borio and White (2003), argues that the financial system has become m
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Den här studien syftar till att öka förståelsen för hur den unga konsumenten mottar, tolkar och resonerar kring ämnet hållbarhetskommunikation. Studien utgår från ett socialkonstruktionistiskt perspektiv och betraktar de kommunikativa processer som konsumenten för kring ett specifikt fall. Det fall som denna studie utgår från är Max Burger AB’s hållbarhetskommunikation som återfinns i företagets dThis research aims to increase the understanding of how the young consumer receives, interprets and argues about sustainability communication. The study is based on a social constructionist perspective and considers the communicative processes expressed by the consumer in a specific case. The case from which this study is based is Max Burger AB's digital sustainability communication. The purpo
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Cell death is an important field of biology that is linked to many other topics in medicine and biology. One of the methods to investigate cell death is through high content screening (HCS) which makes use of robotic microscopy. By this technology, cell death associated organelle membrane permeabilisation and the localisation of certain dyes can be visualised and elucidate a substantial amount of
