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Amyloid β peptide (Aβ) is the crucial protein component of extracellular plaques in Alzheimer’s disease. The plaques also contain gangliosides lipids, which are abundant in membranes of neuronal cells and in cell-derived vesicles and exosomes. When present at concentrations above its critical micelle concentration (cmc), gangliosides can occur as mixed micelles. Here, we study the coassembly of th
Continuous task engagement generally leads to vigilance decrement and deteriorates task performance. However, how conflict effect is modulated by vigilance decrement has no consistent evidence, and little is known about the underlying neural mechanisms. Here we adopted an electroencephalogram dataset collected during a prolonged flanker task to examine the interactions between vigilance and congru
Magnetic susceptibility can be assessed by quantitative susceptibility mapping (QSM), based on measured magnetic resonance imaging (MRI) phase data. The QSM reconstruction process is, however, mathematically challenging and still not fully robust. A signal-generating holmium [Ho(III)] aqueous solution with air-equivalent magnetic susceptibility was prepared, and used as a surrounding medium in a w
Background: Amyloidosis represents a rare yet heterogeneous multi-system disorder associated with a grave prognosis and an enormous psycho-emotional strain on patients, relatives, and caregivers. We here present the overall study design and first results of AMY-NEEDS, a research program aiming to systematically assess the needs of patients suffering from amyloidosis, their relatives and health car
There has been much progress in the field of nanofluidics, and novel applications, such as single-cell analysis, have been achieved. In such cases, controlling the location of the gas/liquid interface is vital and partial hydrophobic modification is frequently used to pin the position of this interface. However, because the fluid manipulating pressure in such devices is comparable to the Laplace p
High-precision localization and machine learning (ML) are envisioned to be key technologies in future wireless systems. This paper presents an ML pipeline to solve localization tasks. It consists of multiple parallel processing chains, each trained using a different fingerprint to estimate the position of the user equipment. In this way, ensemble learning can be utilized to fuse all chains to impr
During bacterial infections at mucosal sites, neutrophils migrate to the mucosa and cross the epithelial barrier. We have examined neutrophil migration across Escherichia coli-stimulated uroepithelial cell layers in an attempt to more fully understand this process. Stimulation of uroepithelial cells with E. coli or interleukin-1α (IL-1α) induced transepithelial neutrophil migration in a time- and
The aim of this study was to describe the performance of a closed loop interstitial laser thermotherapy system in processed liver and to demonstrate its suitability for treating a vascularized tumour in vivo. The thermotherapy system consisted of an Nd:YAG laser and a temperature feedback circuit including an automatic thermometry system and thermistor probes. Experiments in processed liver were p
Road agencies set quantitative targets and adopt related road safety strategics in accordance with each agency's priorities and available resources. Benefit-cost analyses are carried out to support the decision-making process, and alternative measures are ranked according to their expected benefits and benefit-cost ratios, calculated with a safety performance function (SPF) and crash modification
Laser-induced fluorescence (LIF) has been developed for visualization of fuel distribution fields in an operating spark-ignition (SI) engine. Since the standard research fuel iso-octane, does not yield a useful LIF signal a fluorescent additive was used. None of the commonly used seeds were found adequate. A seed not commonly used in this context, 3-pentanone, C2H5COC2H5, was chosen due to favorab
It is speculated that virtual environments (VE) might be used as a training tool in brain injury rehabilitation. The rehabilitation process often involves practicing so-called instrumental activities of daily living (IADL), such as shopping, cooking, and using a telephone. If a brain injury patient is to practice such activities in a VE, the patient must be able to navigate the viewpoint and inter
This thesis deals with the modeling of anisotropic materials at finite deformations. The major emphasis is the development of constitutive models able to account for the evolving directionally dependent properties of these materials. In addition, the numerical implementation of the models developed is addressed. In particular, the following topics are considered. To model finite elasto-plastic de
Fossil fuel subsidies continue to be a considerable barrier to meeting the targets of the Paris Agreement. It is thus crucial to understand the political economy of fossil fuel subsidies and their reform. To understand these mechanisms in the developed world, we use a database of different types of fossil fuel subsidy reforms among Organisation for Economic Co-operation and Development (OECD) coun
Precision medicine should aspire to reduce error and improve accuracy in medical and health recommendations by comparison with contemporary practice, while maintaining safety and cost-effectiveness. The etiology, clinical manifestation and prognosis of diseases such as obesity, diabetes, cardiovascular disease, kidney disease and fatty liver disease are heterogeneous. Without standardized reportin
Background and objective: Laboratories sometimes use different reference ranges for the same antiepileptic drug (AED), particularly for new and poorly investigated drugs. This may contribute to misunderstandings, concerns or inappropriate dose changes, which in turn may affect therapeutic effect, drug safety or treatment adherence. Therefore, the Norwegian Association of Clinical Pharmacology wish
Froth flotation is a common unit operation used in mineral processing. It serves to separate valuable mineral particles from worthless gangue particles in finely ground ores. The valuable mineral particles are hydrophobic and attach to bubbles of air injected into the pulp. This creates bubble-particle aggregates that rise to the top of the flotation column where they accumulate to a froth or foam
Supply chains are difficult to plan because they involve complex relationships that influence supply chain performance. In this paper, discrete-event simulation (DES) is discussed in order to identify if it could be a technique used to improve supply chain planning. Two DES models have been developed and are used in this paper to find out whether DES could be a technique for unraveling the complex
A hot potato: food and meals in families with small children and teenagers. Introduction, with aims and hypothesis The project ‘Konsumenters problemlösningar på livsmedelsmarknadens nya arenor. Matinspiration under tidspress’ [‘Consumers’ problem-solving/solution to the food market’s new arenas: food inspiration against the clock’] initially addressed the following issue: shopping for food and p
The number of devices connected to the Internet grows constantly. This information entity has been labeled the Internet of Things (IoT). One important aspect of this is the industrial applications, sometimes labeled the Industrial Internet of Things (IIoT). Collecting and analyzing the massive amounts of data that industry generates will only become more and more important as technology and the ne
Syfte: Studiens syfte är att undersöka hur pensionerade lärare som undervisat på låg- och mellanstadiet upplever och beskriver sin tillvaro. Deltagarnas upplevelser av övergången från arbete till pension, identiteten som pensionär samt möjligheter och svårigheter under pensionärslivet och hantering av dessa undersöks. Metod: Studien är fenomenologisk. Semistrukturerade intervjuer genomfördes med fPurpose: The purpose of this study is to explore how retired teachers, who had worked in a primary school setting, experience and describe their lives. The study investigates the transition from working to retired life, retiree identity and possibilities and difficulties in the retired life. Method: The study has a phenomenological approach. Semi-structured interviews were conducted with five part
