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Over 50 million people worldwide have epilepsy. In nearly 30% of these cases, epilepsy remains unsatisfactorily controlled despite the availability of over 20 antiepileptic drugs. Moreover, no treatments exist to prevent the development of epilepsy in those at risk, despite an increasing understanding of the underlying molecular and cellular pathways. One of the major factors that have impeded rap
Objectives. To evaluate the distribution and impact of ABO blood groups on postoperative outcomes in patients undergoing surgery for acute type A aortic dissection (ATAAD). Design. A total of 1144 surgical ATAAD patients from eight Nordic centres constituting the Nordic consortium for acute type A aortic dissection (NORCAAD) were analysed. Blood group O patients were compared to non-O subjects. Th
A family of eukaryotic proline racemase-like genes has recently been identified. Several members of this family have been well characterized and are known to catalyze the racemization of free proline or trans-4-hydroxyproline. However, the majority of eukaryotic proline racemase-like proteins, including a human protein called C14orf149, lack a specific cysteine residue that is known to be critical
This paper is based on the Anne Simmonds Memorial Lecture, given by Monika Löffler at the International Symposium on Purine and Pyrimidine Metabolism in Man, Lyon 2019. It is dedicated to H. Anne Simmonds (died 2010) - a founding member of the ESSPPMM, since 2003 Purine and Pyrimidine Society - and her outstanding contributions to the identification and study of inborn errors of purine and pyrimid
In this report, the implementation of a technology called sensor-based sorting technology is analyzed from different perspectives. The technology can be used to identify individual particles in order to sort wanted material from unwanted material. Today, the technology is widely used in different industries such as the food industry, the recycling industry, and to some extent the mining and minera
The main concern of this thesis is to experimentally investigate the turbulent flow and heat transfer in a ribbed channel. Such flows are encountered in many engineering applications, e.g., gas turbine cooling. In order to highlight the physical mechanism of flow separation, only one wall of the channel is fitted with periodic ribs. The inter-rib spacing is set such that the reattachment is allowe
The reactions between three sphalerite samples and ethyl- and n-decylxanthate ions have been studied in aqueous and acetone solutions. Qualitative analysis of the species present on the sphalerite surfaces before and after treatment with these ions have been performed by means of diffuse reflectance infrared Fourier transform spectroscopy. Atomic absorption spectrophotometry has been used to deter
Popular Abstract in Swedish Många beständighetsproblem uppträder i gränsytor mellan material. Exempel är lossfrysning av puts på tegel, avflagning av färg, sprickbildning hos ytskikt, vidhäftningsbrott mellan reparationsmaterial och underlag. I nästan alla fall är nedbrytningen kopplad till alltför höga fuktnivåer i gränsytan. Flera beständighetsproblem, t.ex. frostnedbrytning, uppstår enbart om mThe main impetus for this research was the desire to verify models for determining transient moisture profiles in the capillary range. For the evaluations, transient moisture profiles were both simulated and measured, after which the results of the two methods were compared. The study was performed for on specimens exposed to continuous water absorption, using specimens of both single and combined
Sammanfattning Denna uppsats behandlar det som kommit att kallas ”kvinnorabatt”, gällande kvinnor i egenskap av gärningsmän vid grova våldsbrott ur perspektivet likhet inför lagen. För att se till detta har en mängd variabler beaktats och analyserats, för att genom ett bredare perspektiv finna vad en sådan eventuell särbehandling kan bero på. Att kvinnor särbehandlas inom rättsväsendet uppmärksamSummary This paper discusses what has come to be called "women's discount", regarding women as offenders for serious crimes of violence from the perspective of equality before the law. To ensure this, a number of variables considered and analyzed, to the broader perspective of finding what any such special treatment may depend on. Women in the judiciary received particular attention
Att uppskatta lövyteindex med satellitdata Vegetation har unika spektrala egenskaper som kan användas inom fjärranalys för att få information om viktiga ekologiska parametrar, som t.ex löyteindex (eng. leaf area index, LAI, lövyta per markenhet). LAI styr många ekologiska processer som fotosyntes och transpiration. Med hjälp av satellitbilder kan man uppskatta LAI i stor skala. Vegetation absorLeaf area index, LAI, is an important biophysical parameter in ecological modeling. It is the ratio of leaf area per unit ground area. To obtain LAI over large areas in a fast and convenient way the use of satellite data is important. Aim of the project was to determine if there is a relationship between LAI and red-, NIR reflectance and a couple of vegetation indices: Global Environment Monitorin
Tetra Pak is a large scale organization that provides its customers with a food packaging solution based on laminated carton board in various package formats. The packaging material is produced in more than 50 converting factories represented world wide. The production develops the material in roll form that are loadable in the filling machines. Each roll arrives to the filling site with a barcode
2005 släppte Förenta Nationernas folkrättskommission rapporten "Fragmentation of International Law: Difficulties arising from the diversification and expansion of International Law". Även om fragmenteringen av folkrätten hade varit ett diskussionsämne långt före 2005 fick rapporten verkligen debatten ta fart och fragmentering att bli en av de mest omdebatterade frågorna under senare år b
In recent years the railway has received a lot of negative publicity thanks to the large amount of delay hours that occurs during winter conditions and especially at snowfall. In our railway network, the points are the most targeted problem components were snow and ice cause the most problems. Due to its moving parts and low tolerances for disorder, a few millimeters of gap between the rails is en
Popular Abstract in Swedish Cellulosa är ett av de vanligast förekommande biologiska ämnena på jorden och en mycket viktig råvara. Cellulosa är en polymer, uppbyggd av glukosmolekyler som är bundna till varandra i kedjor. Kedjorna kan bli mycket långa och består ofta av flera tusen glukosmolekyler. Eftersom cellulosakedjor är lineära kan de packa sig parallellt med varandra och bilda styva fibrer Soluble derivatives of cellulose have become increasingly important in industrial products e.g. in pharmaceutical applications and in technical dispersions. The polymer characteristics of modified celluloses are to a high degree determined by the substituent distribution along the polymeric backbone. The distribution will be more or less heterogeneous both due to the fact that polymers from renewa
The introduction of total prostate-specific antigen (tPSA) testing in serum has revolutionized the detection and management of men with prostate cancer. This review will highlight some of the exciting new developments in the field of prostate cancer screening in general and from our SPORE research program at Memorial-Sloan Kettering Cancer Center. First, it is important to understand that the inhe
PurposeTo determine the association between the occurrence of sporadic and periodic fetal heart rate accelerations during labor and acidemia at birth.Materials and methodsThis is a case–control study of fetal heart rate patterns from 364 neonates with acidemia at birth (cord blood pH ResultsDuring the first stage, ≥2 sporadic accelerations were present in 16% of cases and 78% of controls; OR for
Background: Neurofibrillary tangle pathology is thought to drive neurodegeneration in beta-amyloid positive (A+) cognitively normal (CN) individuals, i.e., preclinical Alzheimer’s disease (AD).However, in beta-amyloid negative (A-) CN, the contribution of tau pathology [primary age-related tauopathy (PART)] to neurodegeneration remains uncertain. We investigate the correlation between tau burden m
The surface chemistry of the initial growth during the first or first few precursor cycles in atomic layer deposition is decisive for how the growth proceeds later on and thus for the quality of the thin films grown. Yet, although general schemes of the surface chemistry of atomic layer deposition have been developed for many processes and precursors, in many cases, knowledge of this surface chemi
