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Covalent inhibitors of Bruton tyrosine kinase (BTK) have transformed the therapy of chronic lymphocytic leukemia (CLL), but continuous therapy has been complicated by the development of resistance. The most common resistance mechanism in patients whose disease progresses on covalent BTK inhibitors (BTKis) is a mutation in the BTK 481 cysteine residue to which the inhibitors bind covalently. Pirtob
Innate immunity relies on an effective recognition of the pathogenic microorganism as well as on endogenous danger signals. While bacteria in concert with their secreted virulence factors can cause a number of inflammatory reactions, danger signals released at the site of infection may in addition determine the amplitude of such responses and influence the outcome of the disease. Here, we report t
C4b-binding protein (C4BP) is a multimeric protein with regulatory functions in the complement system. It also interacts with vitamin K-dependent protein S, which is involved in the regulation of the coagulation system. It has been demonstrated that C4BP consists of seven disulfide-linked, identical 70-kDa subunits, which are arranged to give the molecule a spider-like structure. We now have evide
A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ancestries with a wide array of functional genomic datasets to discover regulatory mechanisms underlying lipid associations. We first prioritize lipid-associated genes with expressi
Tourmalines with different compositions show different plane group symmetries in experimental high resolution transmission electron microscopy (HRTEM) when projected along the c-axis. Fe-poor elbaite shows p31m symmetry, while Fe-bearing elbaite shows p3m1 symmetry. Rubellite shows p6 symmetry, while Fe-Mg-Al-bearing tourmaline shows a `pseudo' p6 type of symmetry. Symmetries p3m1 and p6 are not c
Biallelic variants in the Golgi SNAP receptor complex member 2 gene ( GOSR2) have been reported in progressive myoclonus epilepsy with neurodegeneration. Typical clinical features include ataxia and areflexia during early childhood, followed by seizures, scoliosis, dysarthria, and myoclonus. Here, we report two novel patients from unrelated families with a GOSR2-related disorder and novel genetic
Cosmogenic radionuclides (e.g., 10Be) from ice cores are a powerful tool for solar reconstructions back in time. However, superimposed on the solar signal, other factors like weather/climate and volcanic influences on 10Be can complicate the interpretation of 10Be data. A comprehensive study of 10Be records over the recent period, when atmospheric 10Be production and meteorological conditions are
A wide range of literatures have identified the capitalist organisation of societies, and the capitalist growth imperative central to this organisation, as the root cause of the catastrophic climate and biodiversity crises. Highlighting the need to break with this imperative, a growing community of scholars generally viewed as anti- and postcapitalist, there is no consensus on how precisely to con
Perioperative hyponatremia, due to non-osmotic release of the antidiuretic hormone arginine vasopressin, is a serious electrolyte disorder observed in connection with many types of surgery. Since blood loss during surgery contributes to the pathogenesis of hyponatremia, we explored the effect of bleeding on plasma sodium using a controlled hypotensive hemorrhage pig model. After 30-min baseline pe
Second harmonic generation is popular due to its numerous applications in different technologies dealing with multiple fields of science. The rapid technical advancement with the second harmonic generation demands parallel development in the theoretical understanding. With this view in mind, in our three papers, we theoretically investigated second harmonic generation from different systems in an
BACKGROUND: Methylchloroisothiazolinone, in combination with methylisothiazolinone (MCI/MI), and MI alone are common preservatives. The incidences of MCI/MI and MI-alone contact allergies have risen markedly worldwide, leading to changes in their use in products.OBJECTIVES: The aim of the study was to determine the incidences of positive patch test reactions and factors associated with MCI and/or
Cercozoa are abundant free-living soil protozoa and quantitatively important in soil food webs; yet, targeted high-throughput sequencing (HTS) has not yet been applied to this group. Here we describe the development of a targeted assay to explore Cercozoa using HTS, and we apply this assay to measure Cercozoan community response to drought in a Danish climate manipulation experiment (two sites exp
Examensarbetet har gjorts på Nolato MediTech AB i Lomma via avdelning för Industriell produktion på Lunds Tekniska Högskola. Syftet har varit att analysera flödet från att produkt lämnar maskin tills den lämnar fabriken, identifiera problem och hitta eventuella lösningar. Bakgrunden till examensarbetet är att Nolato MediTech AB verkar inom medicinteknik-branschen som en kontraktstillverkare där tiThe master thesis has been performed at Nolato MediTech AB in Lomma through the Division of Production and Materials Engineering at Lund University. The purpose of the master thesis has been to analyze the internal flow of products from departure from the machine until the departure from the factory, identify problems and present solutions. The background of the thesis is that Nolato MediTech AB i
This research aims to understand the frames used by conspiracy theorists by establishing a new pathway in media framing, or in other words a media framing micro-theory, called conspiratorial framing. The aims are accomplished through a critical analysis of the case of Alex Jones, a conspiracy theorist, and InfoWars, the media channel through which Jones operates. Through frame analysis, accomplis
FN:s råd för mänskliga rättigheter har flera gånger uppmärksammat det växande problemet med juridiska trakasserier mot journalister i världen. I ett fungerande demokratiskt samhälle är det viktigt att skydda så väl yttrande- som pressfrihet. Rådet har betonat att regler kring ärekränkning utnyttjas för att tysta ner den offentlig debatten och granskningen av makten. Vanligtvis går den här bestraffThe UN Human Rights Council has several times addressed the expanding issue of judicial harassments against journalists around the world. In a functioning democracy, it is important to protect the freedom of expression and the freedom of the press. The Council has emphasized that laws on defamation are used to intimidate public debate and public scrutiny. Generally, the term for this method is str
Lift force is a crucial factor in aviation, particularly during landing phases where maintaining optimal lift is essential for safety and performance. This thesis explores the effectiveness of suction and blowing control methods in enhancing aerodynamic performance and increasing lift force. By investigating these control techniques, the study aims to provide recommendations for practical applicat
Detta examensarbete är en fallstudie av Tumaini Open School för gravida studenter och studerande mödrar i Tabora, Tanzania. Genom den ideella organisationen Ingenjörer utan gränser Sverige genomförde författarna en Minor Field Study i Tanzania för att fastställa efterfrågade eltjänster, det resulterande elbehovet och den maximala dagliga effektkurvan för skolan vid fullskalig verksamhet. Vidare prThis master thesis is a case study of Tumaini Open School for pregnant and mothering students located in Tabora, Tanzania. Through the volunteer organisation Engineers Without Borders Sweden, the authors conducted a Minor Field Study to Tanzania in order to determine the requested electricity services, resulting electricity demand and maximum daily load profile for the school at full-scale operati
