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The shielding at an accelerator-driven spallation neutron facility plays a critical role in the performance of the neutron scattering instruments, the overall safety, and the total cost of the facility. Accurate simulation of shielding components is thus key for the design of upcoming facilities, such as the European Spallation Source (ESS), currently in construction in Lund, Sweden. In this paper
We report the development of a high-level bacterial expression system for the Alzheimer's disease-associated amyloid beta-peptide (A beta), together with a scaleable and inexpensive purification procedure. A beta(1-40) and A beta(1-42) coding sequences together with added ATG codons were cloned directly into a Pet vector to facilitate production of Met-A beta(1-40) and Met-A beta(1-42), referred t
Background: Previous studies of the natural history of alpha-1-antitrypsin (AAT) deficiency are mostly based on highly selected patients. The aim of this study was to analyse the mortality of PiZZ individuals. Methods: Data from 1339 adult PiZZ individuals from the Swedish National AAT Deficiency Registry, followed from 1991 to 2008, were analysed. Forty-three percent of these individuals were ide
Despite an increasingly growth of professional guidelines, textbooks and research about ethics in health care, awareness about ethics in Danish physiotherapy private practice seen vague. This article explores how physiotherapists in Danish private practice, from an ethical perspective, perceive to practice physiotherapy. The empirical data consists of interviews with twenty-one physiotherapists. T
For the very first time we present 3D simulations of planets embedded in stellar irradiated discs. It is well known that thermal effects could reverse the direction of planetary migration from inwards to outwards, potentially saving planets in the inner, optically thick parts of the protoplanetary disc. When considering stellar irradiation in addition to viscous friction as a source of heating, th
Life oil earth was formed during billions of years, exposed to, and shaped by the original physical forces such as gravitation, cosmic irradiation, atmospheric electric fields and the terrestrial magnetism. The Schumann resonances at 7.4 Hz are all example of oscillations possibly important for life.(1)) The existing organisms are created to function in harmony with these forces. However, in the l
Under år 2010 genomfördes en lagändring rörande den svenska bestämmelsen i BrB 4 kap. 1a § avseende människohandelsbrottet. Ändringen föranleddes av att problematik avseende bestämmelsens tillämpning och effektivitet hade uppmärksammats. Inom ramen för den utredning som tillsattes med anledning av detta identifierades fem problemområden avseende människohandelsbestämmelsens utformning; i) användan
Denna uppsats problematiserar och undersöker målbolagsstyrelsens ställning vid offentliga uppköpserbjudanden genom att belysa oklarheter som råder kring målbolagsstyrelsens agerande, framförallt till följd av att ABL inte har anpassats till takeover-reglerna och vice versa. Målbolagsstyrelsens komplexa ställning exemplifieras i denna uppsats av en utredning av vilka överväganden och vilket aktieboThis thesis problematizes and investigates the role of the board in a public company facing a friendly takeover bid. It does this by illuminating ambiguities which concern actions of the target company board, due to the fact that the Swedish Companies Act and the Swedish Takeover Rules have not been brought into conformity with one another. The complicated role of the board is exemplified by the i
Swedish penal law does not exculpate on the grounds of diminished accountability; persons judged to suffer from severe mental disorder are sentenced to forensic psychiatric care instead of prison. Re-introduction of accountability as a condition for legal responsibility has been advocated, not least by forensic psychiatric professionals. To investigate how professionals in forensic psychiatry woul
This paper presents a first analysis of the distribution of head and eyebrow movements as a function of (a) phonological prominence levels (focal, non-focal) and (b) word accent (Accent 1, Accent 2) in Swedish news broadcasts. Our corpus consists of 31 brief news readings, comprising speech from four speakers and 986 words in total. A head movement was annotated for 229 (23.2%) of the words, while
Haldex Barnes Hydraulics (HBH) is a company which produces hydraulic aggregates for use in forklifts, construction equipment, and trucks. The last two years the company has expanded. This has lead to an insufficient production of aggregates. Thus wishes HBH to increase their production without making to large investments. This report includes a now-state analysis of the problems and where they ar
Geometrid moths, the second largest radiation of Lepidoptera, have been the target of extensive phylogenetic studies. Those studies have flagged several problems in tree topology that have remained unanswered. We address three of those: (i) deep nodes of Geometridae (subfamilies Sterrhinae + Larentiinae, or Sterrhinae alone as sister to all other subfamilies), (ii) the taxonomic status of subfamil
PurposeTo develop an application for the Pentacam HR for the purpose of optimising the accuracy of the diagnosis of progressive keratoconus.MethodsMeasurements were performed on one randomised eye in twenty-five subjects with keratoconus Stage 1-2 according to the Amsler-Krumeich classification on two occasions, three days apart. Four replicate measurements were made by a single examiner on each o
Background: Middle Eastern immigrants represent a growing population in Sweden today. This group are at higher risk for type 2 diabetes than the native population, but are also shown to exhibit unique properties; despite an abundance in traditional cardiometabolic risk factors such as obesity, dearranged blood lipids and diminished physical acitivity, this group seem to exhibit lower blood pressur
Background: According to the “brain-reserve hypothesis” in Alzheimer’s disease (AD), patients with more years of education are expected to have higher cognitive status during adulthood. Hence, they might have a relatively larger burden of AD pathology and a more advanced level of the disease when dementia is clinically evident. Higher educated people would also be expected to perform better on sta
Aim: To perform a model-based analysis of the short- and long-term health benefits and costs of further increased implementation of empagliflozin for people with type 2 diabetes and established cardiovascular disease (eCVD) in Sweden. Materials and Methods: The validated Institute for Health Economics Diabetes Cohort Model (IHE-DCM) was used to estimate health benefits and a 3-year budget impact,
