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Popular Abstract in Swedish I samband med en kärlskada startar en kaskad av reaktioner som leder fram till bildandet av ett blodkoagel. Det är viktigt att bildandet av blodkoagel begränsas till det skadade området. Blodkoagulationen är därför reglerad av antal antikoagulanta system av vilka det viktigaste är protein C systemet. I detta system samverkar aktivt protein C (APC) tillsammans med ett anProtein S functions as a cofactor to activated protein C (APC) in the degradation of factors Va and VIIIa. In plasma protein S circulates in two forms; 30-40 % circulates as free protein S molecules while the remaining 60-70 % exists in a 1:1 complex with C4b-binding protein (C4BP). Only the free form of protein S functions as a cofactor to APC. Protein S is a mosaic protein composed of four discr

Context While vascular endothelial growth factor-targeted therapy and mammalian target of rapamycin inhibition are effective strategies in treating clear cell renal cell carcinoma (ccRCC), the most effective therapeutic approach for patients with non-clear cell RCC (non-ccRCC) is unknown. Objective To systematically review relevant literature comparing the oncological outcomes and adverse events o

The human-environment connection in the mostly rural drylands of sub-Saharan Africa forms a complex, interlinked system that provides ecosystem services. This system is susceptible to climatic variability that impacts the supply of its products, and high population growth, which impacts the demand for these products. When plants remove carbon dioxide from the atmosphere through the process of phot

This panel is devoted to an exploration of multimodal, visual staging of meaning in the Middle East and its transnational interconnectedness. Presentations will discuss examples of visual inventiveness in different and multimodal medial contexts, varying both in terms of motivations, positions of power and visual strategies employed. The panel invites reflection on how the study of current visual

Background: Blood lipid levels including low-density lipoprotein cholesterol ( LDL-C), high-density lipoprotein cholesterol ( HDL-C), and triglycerides ( TG) are highly heritable. Genome-wide association is a promising approach to map genetic loci related to these heritable phenotypes. Methods: In 1087 Framingham Heart Study Offspring cohort participants ( mean age 47 years, 52% women), we conduct

The use of Penman-Monteith (PM) equation in thermal remote sensing based surface energy balance modeling is not prevalent due to the unavailability of any direct method to integrate thermal data into the PM equation and due to the lack of physical models expressing the surface (or stomatal) and boundary layer conductances (g(S) and g(B)) as a function of surface temperature. Here we demonstrate a

Background: Respiratory viruses are the leading cause of lower respiratory tract infection (LRTI) and hospitalisation in infants and young children. Respiratory syncytial virus (RSV) is the main infectious agent in this population. Palivizumab is administered intramuscularly every month during five months in the first RSV season to prevent serious RSV LRTI in children. Given its high cost, it is e

Background: Anorectal malformations (ARM) occur in 1/5000 live births (1.2–1.6:1 male:female). Associated malformations are common, influencing, together with ARM-subtype complexity, long-term outcome, follow-up and need of transitional care. Reconstructive surgery, the posterior sagittal anorectoplasty (PSARP), is performed in infancy, either as a single-stage or multi-stage procedure with a colo

Popular Abstract in Swedish Cancer i tjock- och ändtarm drabbar årligen drygt 5000 svenskar. En rad faktorer har satts i samband med tumöruppkomst i tarmen, bl a ärftlighet, inflammatorisk tarmsjukdom, kost och motion, men det är till stor del okänt hur dessa faktorer orsakar cancerutveckling. Genetiska förändringar styr tumörutvecklingen Tumörerna utvecklas oftast från ett godartat förstadium, Colorectal cancer is one of our most common malignancies and the second leading cause of cancer death worldwide. About 1/3 of the tumors are located in the rectum. Treatment advances such as the introduction of the standardized surgical technique total mesorectal excision (TME), pre-operative radiotherapy, and adjuvant chemotherapy have reduced the previously high local recurrence rates and improv

Popular Abstract in Swedish Enbart i Sverige drabbas tusentals personer årligen, kvinnor som män, av plötsligt cirkulationsbortfall (akut ischemi) i ett ben till följd av blodpropp i en artär. Tillståndet är akut och innebär ett direkt hot mot såväl liv som lem. Personer som drabbas är ofta äldre, och de har ofta många andra sjukdomar med sig i bagaget. För att rädda benet, och patienten, krävs aBackground: Acute ischemia of the lower limb is a vascular emergency associated with amputation and death. Patients suffering from acute limb ischemia are usually elderly, and multiple comorbidities are often present. Intra-arterial thrombolysis is, perhaps, the most important minimal-invasive treatment option available today. Although uncontrolled hemorrhage is a dreaded complication, it is consi

Objective: To describe the clinical and ultrasound characteristics of serous and mucinous cystadenomas in the adnexa. Methods: This was a retrospective international multicenter study. Using the International Ovarian Tumor Analysis (IOTA) database, patients with a histological diagnosis of serous or mucinous cystadenoma who had undergone preoperative ultrasound examination between 1999 and 2016 (I

Importance Adverse pregnancy outcomes are recognized risk enhancers for cardiovascular disease, but the prevalence of subclinical coronary atherosclerosis after these conditions is unknown.Objective To assess associations between history of adverse pregnancy outcomes and coronary artery disease assessed by coronary computed tomography angiography screening.Design, Setting, and Participants Cros

Multigene expression signatures provide a molecular subdivision of early breast cancer associated with patient outcome. A gap remains in the validation of such signatures in clinical treatment groups of patients within population-based cohorts of unselected primary breast cancer representing contemporary disease stages and current treatments. A cohort of 3520 resectable breast cancers with RNA seq

Rodent models are important research tools for studying the pathophysiology of traumatic brain injury (TBI) and developing new therapeutic interventions for this devastating neurological disorder. However, the failure rate for the translation of drugs from animal testing to human treatments for TBI is 100%. While there are several potential explanations for this, previous clinical trials have reli

With the growth of the cloud industry in recent years, the energy consumption of the underlying infrastructure is a major concern.The need for energy efficient resource management and control in the cloud becomes increasingly important as one part of the solution, where the other is to reduce the energy consumption of the hardware itself.Resource management in the cloud is typically done using rel

Background:Colorectal cancer in the third most diagnosed cancer in Sweden and the second most common cause of cancer-related death in Sweden and worldwide. 10-30% of the cases present as emergencies, of which 80% are caused by large bowel obstruction (LBO). Most of these patients undergo emergency resection which is associated with high rates of morbidity and mortality. To overcome the risk with e

Popular Abstract in Swedish Yttre faktorerna i omgivningen som UV-strålning från solen, rökning, läkemedel, maten och påfrestande livssituationer kan leda till att kroppens celler börjar överproducera molekyler som kallas syrefria radikaler. Dessa molekyler reagerar kemist mycket lätt med omgivande ämnen. När syrefria radikaler bildas i kroppen i normala mängder ingår de som en del av immunförsvarOxidative stress can cause damage to DNA, proteins and lipids and is associated with inflammation and various human diseases as cancer, atherosclerosis, and autoimmune diseases. Polyphenol-rich diet, such as fruits and berries, may act as antioxidants and prevent oxidative stress and, thereby, associated diseases. Administration of lactic acid bacteria (LAB) can affect the microflora in the gastro

Accepted manuscripts are peer-reviewed but have not been through the copyediting, formatting, or proofreading process. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly at

https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/eneuro.0106-15.2015.pdf - 2026-07-16

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