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Introduction: Galectin-3 is a pro-fibrotic β-galactoside binding lectin highly expressed in fibrotic liver and implicated in hepatic fibrosis. Selvigaltin (previously known as GB1211) is a novel orally active galectin-3 small molecule inhibitor that has high affinity for galectin-3 (human KD = 25 nM; rabbit KD = 12 nM) and high oral bioavailability in rabbits and man. In this study the efficacy of

Background: Cervical cancer is preventable through screening and vaccination against high-risk human papillomavirus (hr-HPV). For a screening program to be successful it is vital that the clinical management and follow-up regime of patients with abnormal screening results is well developed and that the attendance rate for follow-up is high. The aim of the study was to analyze how effective conizat

Importance: Clinical studies confirm that obesity is a risk factor for recurrence in postmenopausal women with hormone receptor-positive (HR+) breast cancer. Evidence suggests that women with obesity do not obtain similar protection from aromatase inhibitors as women with healthy weight. Objective: To examine the associations of body mass index (BMI) with recurrence. Design, Setting, and Participa

PURPOSE: There is uncertainty whether ER-low tumors with a 1-10% immunohistochemical staining of nuclei represent a distinct molecular biological entity of BC, posing significant challenges for their clinical management and developing novel therapies. We aimed to elucidate ER-low tumor biology.EXPERIMENTAL DESIGN: We analyzed primary tumors included in a Swedish population-based SCAN-B BC cohort,

Aerosols from volcanic eruptions impact our climate by influencing the Earth's radiative balance. The degree of their climate impact is determined by the location and injection altitude of the volcanic SO2. To investigate the importance of utilizing correct injection altitudes, we ran climate simulations of the June 2009 Sarychev eruptions with three SO2 datasets in the Community Earth System Mode

Introduction: In recent years, the e-commerce industry has developed at extremely high speed all over the world and becomes the sunrise industry. Besides, there is a megatrend that customers are pursuing better experience along the whole shopping journey. Statistics show that good reverse logistics service is an efficient way to improve customers satisfaction level. Among the reverse logistics, th

Title: Accelerating Service Innovation with Global Account Management – A Case Study at a Manufacturing MNC Author: Emma Malmström – Master of Science in Industrial Engineering and Management, em.malmstrom@gmail.com Tutors: Malin Olander Roese – PhD Researcher, Department of Design Sciences, Faculty of Engineering, Lund University and Susanna Bill – PhD Student, Department of Design Sciences, Fa

Contract law has traditionally been regulated by national law which has raised certain problems in cross-border transactions caused by the divergences in domestic contract law among the Member States. Therefore, the diversity of national law has been increasing the challenges in practice for entrepreneurs which is causing a lack of legal certainty, uniformity and creates serious obstacles that hin

This thesis aims at comparing the differences between Chinese welfare system and Swedish welfare system in respects of maternity insurance, parental leave and childcare. The reason comparing welfare system in these specific aspects is because they have intense relations with the mothers’ and children’s benefits. They also influence the mothers’ will of pregnancy. Selecting these two countries as t

I denna studie görs en livscykelanalys på en solfångare som Kristianstads Industri Service AB (KISAB) utvecklar. Även en mindre jämförelse görs med en solfångarstudie från Battisti, R (2005). KISAB:s solfångare har inga absorbatorflänsar utan den fungerar liknande en integrerad vattentank men med väldigt lite medium i den. KISAB:s solfångare består till 80 % av aluminium eftersom både absorbatorn This paper reports the result of a life-cycle analysis done on a solar thermal collector in Sweden. Kristianstad Industri Service AB (KISAB) is developing a solar thermal collector with a framework and absorbing plate made out of aluminium and no flow tubes. The aluminium is instead hollow and the whole area of the absorbing plate is therefore in contact with the coolant. The solar thermal collect

Background : In order to increase access to antiretroviral therapy (ART) in HIV-infected children, paediatric HIV care has been introduced in health centres in Ethiopia, where patients are managed by health professionals with limited training. Objective : To compare outcomes of paediatric HIV care in hospital and health centre clinics and to determine risk factors for death and loss to follow-up (

Popular Abstract in Swedish Medfödda hjärtfel hos barn är förenade med en varierande kombination av förtjockning av hjärtmuskeln, volym- och tryckbelastning av hjärtat, samt nedsatt syremättnad i blodet. Hos barn med medfödda hjärtfel, och förvärvade hjärtsjukdomar ändringar i kranskärlsblodflödet uppstå och påverka hjärtfunktionen eller leda till hjärtinfarkt. En tillförlitlig non-invasiv metod bHeart diseases in children cause different combinations of myocardial hypertrophy, increased intra-ventricular pressures, volume overload and decreased oxygen saturation. This may affect basal coronary flow and the ability of the heart to maximally increase coronary flow. Transthoracic and intracoronary Doppler techniques were used to register coronary flow and coronary flow reserve (CFR) in norma

BACKGROUND: Gonadotropin-releasing hormone (GnRH) antagonists have been reported to have beneficial effects on lower urinary tract symptoms in patients with benign prostatic hyperplasia. OBJECTIVE: Our aim was to investigate the effects of ganirelix, a GnRH receptor antagonist, on bladder function and detrusor overactivity (DO) in female rats. DESIGN, SETTING, AND PARTICIPANTS: Female Sprague-Dawl

Background: Treatment decisions can be difficult in men with low-risk prostate cancer (PCa). Objective: To evaluate the ability of a panel of four kallikrein markers in blood-total prostate-specific antigen (PSA), free PSA, intact PSA, and kallikrein-related peptidase 2-to distinguish between pathologically insignificant and aggressive disease on pathologic examination of radical prostatectomy (RP

Mechanical properties and rate of ATP breakdown (JATP) have been determined in the chemically skinned guinea-pig taenia coli at 22 degrees C. The influence of varied [Ca2+], [Mg ATP] and muscle length were investigated. The shortening response after a step decrease in force (isotonic quick release) was highly curvilinear in the first 100-200 ms. This effect was shown to be a time-dependent respons

BackgroundA seven-year follow-up of heroin dependent patients treated in a buprenorphine-maintenance program combining contracted work/education and low tolerance for non-prescribed drug use. Gender-specific differences in outcome were analysed. MethodsA consecutively admitted cohort of 135 men and 35 women, with eight years of heroin abuse/dependence on average was admitted to enhanced buprenorph

Accumulated carbon uptake, apparent quantum yield (AQY) and light-saturated net CO2 assimilation (A(sat)) were used to assess the responses of photosynthesis to environmental conditions during spring for three consecutive years. Whole-tree chambers were used to expose 40-year-old field-grown Norway spruce trees in northern Sweden to an elevated atmospheric CO2 concentration, [CO2], of 700 mu mol C

The purpose of this thesis project was to analyse and evaluate different systems for installation of piperun in ceilings. Main focus lay on how the systems influence the installer from an ergonomic point of view as well as productivity in terms of installation time. Several studies have been performed during this project using a variety of methods such as observations, interviews, questionnaires a

Problem discussion: The process of paper production includes numerous steps from that a customer order is received to that a finished product is delivered to the customer. A desire exists at Holmen Paper to be able to ease and improve the complex operational methods through the use of computer-aided simulation. Based on the reasoning above the problem to solve in this master thesis is to resolve w

The project “ETT-Modular system for timber transport” investigates the possibilities of making logging shipments more effective, decrease their fuel consumption and road wear without compromising traffic safety. As part of this project a timber vehi-cle, the ETT-vehicle, that pulls four piles of timber, is 30 metres long, and has a gross combination weight of 90 tons, is tested on a distance betwe