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Background About 30% of cases of chronic lymphocytic leukaemia (CLL) carry quasi-identical B-cell receptor immunoglobulins and can be assigned to distinct stereotyped subsets. Although preliminary evidence suggests that B-cell receptor immunoglobulin stereotypy is relevant from a clinical viewpoint, this aspect has never been explored in a systematic manner or in a cohort of adequate size that wou
Popular Abstract in English The main reason that we humans exist at all is because of photosynthesis. The food we eat, the oxygen we breath, most of the energy that warms our homes and powers our electronics are all products of photosynthesis. Over millions of years, plants, algae and some bacteria have developed biomachinery to harness solar energy and thrive. They do this by fixing carbon into cAlmost all life on Earth depends on the products of photosynthesis — the biochemical process whereby solar energy is stored as chemical-rich compounds. The energy of captured photons is transferred through a network of pigment-protein complexes towards the reaction center. The reaction center is responsible for trans-membrane charge separation, which generates a proton motive force which drives al
Popular Abstract in Swedish FN:s barnkonvention formulerar barns och ungas behov i termer av mänskliga rättigheter. Sverige ratificerade konventionen efter ett beslut i riksdagen den 21 juni 1990, utan att reservera sig på någon punkt. Konventionens budskap kan sammanfattas i tre ord: Barn skall respekteras. Vuxna skall se barnet, sträva efter att förstå det och vidta åtgärder som bedöms vara tillThe main purpose was to investigate children's participation in the decision-making processes in health care. Twenty-four children (0-18 år)admitted to hospital, their parents, and the staff present were observed during totally 135 hours in order to (i) identify the children's needs, (ii) their participation in the decision-making processes, and (iii) their parents' participation. Twenty-six child
Popular Abstract in Swedish Det blir allt vanligare att man ersätter förlorade och skadade kroppsdelar med ett biomaterial (vanligtvis ett metall eller polymer implantat). Exempel på vanliga användningsområden är; suturer, kärl, hjärtklaffar, pacemakers, katetrar, ledproteser, fixationsskruvar för skelett och konstgjorda tänder samt kapslar för långsam frisättning av medicin. Trots det rutinmässigThe biological response to different implanted biomaterials vary. The relative importance of factors in the material and host for this variation are at present incompletely known. The variation in the cellular response to specific proteins and the rapid adsorption of proteins to surfaces exposed to biological environments has created the hypothesis that the cellular interactions with biomaterials
The present study examined the rheological blood velocity profile in the conduit femoral artery during rhythmic muscle contractions at different muscle forces. Eight healthy volunteers performed one-legged, dynamic knee-extensor exercise at work rates of 5, 10, 20, 30, and 40 W at 60 contractions per minute. The time and space-averaged, amplitude-weighted mean ( V-mean) and maximum (V-max) blood f
The evaluation of satellite precipitation products (SPPs) at regional and local scales is essential in improving satellite-based algorithms and sensors, as well as in providing valuable guidance when choosing alternative precipitation data for the local community. The Tropical Rainfall Measuring Mission (TRMM) has made significant contributions to the development of various SPPs since its launch i
Objectives To study the impact of time in therapeutic range (TTR) and international normalised ratio (INR) variability on the risk of thromboembolic events, major bleeding complications and death after mechanical heart valve (MHV) implantation. Additionally, the importance of different target INR levels was elucidated. Methods A retrospective, non-randomised multicentre cohort study including all
Hippocampal extracellular levels of noradrenaline (NA), 5-hydroxytryptamine (5-HT), and 5-hydroxyindoleacetic acid (5-HIAA) were monitored with the microdialysis technique in freely moving rats. In one experiment 30 min samples were collected during 24 h of continuous perfusion, and the monoamine output was compared to the behavioural activity state, as arbitrarily classified in three categories:
Bland vilda djur finns närmast ett oräkneligt antal patogener. Dessa kan i vissa fall ge utbrott av zoonotiska sjukdomar vilket har hänt vid upprepade tillfällen under mänsklighetens historia. Men varför kan endast vissa av de patogener som normalt finns hos vilda djur infektera människor? Fågelinfluensa och West-Nile virus kan överföras från fåglar till människor medan rabies kan överföras från hParasites live on or inside their hosts and usually cause fitness loss, sometimes even lead to outbreaks of emerging infectious disease. Understanding how a parasite can infect its hosts (i.e., host specificity of the parasite) is important to both basic studies on disease evolution and the whole ecosystem health.In this thesis, I use avian haemosporidians, a group of species-rich protozoans as a
Importance: Preterm birth has previously been associated with increased risks of hypertension and diabetes, but not ischemic heart disease (IHD), in adulthood. The reasons for this lack of association with IHD despite associations with its risk factors have been elusive, but may be associated with methodologic issues, such as survivor bias, in prior studies. Objective: To determine whether preterm
A new EU directive on used vehicles has recently been introduced. It demands that for every scrapped car, at least 85% by weight must be recycled by the year 2006 and 95% by 2015. Today this level is about 80%. The growing car disassembly industry was chosen as the study object of this thesis. Due to the increased demands on recycling, the disassembly industry is expected to undergo comprehensive
Background: Current equations for estimated glomerular filtration rate (eGFR) that use serum creatinine or cystatin C incorporate age, sex, and race to estimate measured GFR. However, race in eGFR equations is a social and not a biologic construct.Methods: We developed new eGFR equations without race using data from two development data sets: 10 studies (8254 participants, 31.5% Black) for serum c
Importance: Obsessive-compulsive disorder (OCD) is associated with adverse health-related outcomes. However, pregnancy and neonatal outcomes among women with OCD have been sparsely studied. Objective: To evaluate associations of maternal OCD with pregnancy, delivery, and neonatal outcomes. Design, Setting, and Participants: Two register-based cohort studies in Sweden and British Columbia (BC), Can
City marketing and convention bureaus value propositions in the post-covid timeThe role of convention bureaus across the world is to market destinations and cities.This paper explores destination marketing in the post pandemic time. It focusses on thevalues that convention bureaus, a key actor in the meetings industry, propose topotential visitors. The concept of value propositions (VPs) is common
Soil erosion by water is a major cause of landscape degradation in semi-humid to semi-arid Mediterranean environments. Terrain particularly susceptible to the phenomenon witness a combination of erosive soil, unconsolidated rock type, steep slope, high rainfall intensity, active tectonic movement, rapid land use change and intense human interference. Current erosion models (e.g. USLE, RUSLE) are b
Background: Infertile men with non-obstructive azoospermia (NOA) have impaired spermatogenesis. Dilated and un-dilated atrophic seminiferous tubules are often present in the testes of these patients, with the highest likelihood of active spermatogenesis in the dilated tubules. Little is known about the un-dilated tubules, which in NOA patients constitute the majority. To advance therapeutic strate
Sammanfattning För ganska exakt ett år sedan, den 25 maj 2018, började dataskyddsförordningen, Europaparlamentets och rådets förordning (EU) 2016/679 av den 27 april 2016, om skydd för fysiska personer med avseende på behandling av personuppgifter och om det fria flödet av sådana uppgifter och om upphävande av direktiv 95/46/EG (allmän dataskyddsförordning), allmänt känd som GDPR efter engelskansAbstract Approximately one year ago, on May 25, 2018, the General Data Protection Regulation, Regulation (EU) 2016/679 of the European Parliament and of the Council of 27 April 2016 on the protection of natural persons with regard to the processing of personal data and on the free movement of such data, and repealing Directive 95/46/EC (General Data Protection Regulation), known as the GDPR, appl
The grain growth of WC in WC-7%Co cemented carbides with Cr-addition was investigated for cemented carbides synthesized from four different raw materials varying in grain size. Cr additions were 4%of the Co binder phase. To investigate the effect of Cr on grain growth two of the raw materials were also synthesized without Cr-additions. To investigate the effect of cobalt content on grain growth ce
