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Embedded computer systems are subject to a multitude of requirements. These include real-time requirements, that is, such computers must respond to external events within limited time. Many systems, such as satellites and telephone switches, must also operate unattended for long periods of time. They must not fail due to defective software. Modern object-oriented programming languages, particular
Slow-release strong opioids (SRSO) are indicated in patients with severe chronic pain. Side effects, lack of efficacy and risk of dependency limit their use in clinical practice. The aim of this study was to explore prescription patterns of SRSO in Swedish real-world data on patients with a diagnosis related to chronic pain (DRCP). Patient-level data were extracted from the national prescriptions
Uncertainty quantification (UQ) tasks, such as sensitivity analysis and parameter estimation, entail a huge computational complexity when dealing with input-output maps involving the solution of nonlinear differential problems, because of the need to query expensive numerical solvers repeatedly. Projection-based reduced order models (ROMs), such as the Galerkin-reduced basis (RB) method, have been
Introduction Individual cognitive behavioural therapy (CBT) with exposure and response prevention is an effective treatment for obsessive-compulsive disorder (OCD). However, individual CBT is costly and time-consuming, requiring weekly therapy sessions for 3-4 months. A 4-day intensive version of CBT for OCD delivered in group format has been recently developed in Norway (Bergen 4-day treatment, B
TP53 is the most frequently mutated gene in human cancer. This gene shows not only loss-of-function mutations but also recurrent missense mutations with gain-of-function activity. We have studied the primary bone malignancy osteosarcoma, which harbours one of the most rearranged genomes of all cancers. This is odd since it primarily affects children and adolescents who have not lived the long life
BACKGROUND: Lynch syndrome is a rare familial cancer syndrome caused by pathogenic variants in the mismatch repair genes MLH1, MSH2, MSH6, or PMS2, that cause predisposition to various cancers, predominantly colorectal and endometrial cancer. Data are emerging that pathogenic variants in mismatch repair genes increase the risk of early-onset aggressive prostate cancer. The IMPACT study is prospect
Written submissions or comments as a response on an EIS (Environmental Impact Statement) rank as one of the most common forms of public participation. Within public participation research there appears to be an international dearth of knowledge concerning such written submissions. The possible impact of such responses on an EIS is - with few exceptions - seldom put in focus. The aim in the present
Context: MicroRNAs (miRNA) are noncoding RNAs that post- transcriptionally regulate gene expression. Their altered expression and function have been observed in most urologic cancers. MiRNAs represent potential disease biomarkers and novel therapeutic targets. Objective: To review and evaluate the evidence implicating miRNAs in the pathogenesis of prostate cancer (PCa), bladder cancer (BCa), and r
Popular Abstract in Swedish Artiodactyla (partåiga hovdjur) är uppdelad i tre underordningar, Suiformes (grisar och flodhästar), Tylopoda (kameler och lamor) och Ruminantia (kor, hjortar, antiloper och giraffer). Studien syftade till att analysera släktskapen mellan de olika underordningarna och ordningen Cetacea (valar) genom att sekvensera mitokondrie DNA och jämföra sekvenserna. I våra släktskArtiodactyla (eved-toed ungulates) and Cetacea (whales) are two mammalian orders that are commonly recognised as sistergroups. Recently it has been suggested that Cetacea originated within Artiodactyla, but the relationships among the different artiodactyl lineages and Cetacea have not been conclusively established. In the present study the mitochondrial genome of the pig (Sus scrofa), the hippopo
In this paper we study an optimization problem relevant for wireless networks. In such networks links are subject to capacity disruptions caused by changing weather/channel condition that force to adapt the modulation and coding schemes to the observed condition. To cope with this issue in network optimization, we need to consider a so called link availability set A and a routing strategy that can
Detection of genotype-specific human papillomavirus (HPV) capsid antibody in serum suggests past HPV infection. Also, these antibodies appear to correlate with vaccine-induced protection against infection, at least in animal models. However, each laboratory defines a reactive result differently and there is no agreed definition of what level of response indicates sero-reactivity. Standardization o
To estimate the incidence and extension of visceral organ infarction, and to evaluate potential causes, in patients with autopsy-verified nonocclusive mesenteric ischaemia (NOMI) and transmural intestinal infarction. In Malmo, Sweden, the autopsy rate between 1970 and 1982 was 87%, creating possibilities for a population-based study. Amongst 23 446 clinical autopsies, 997 cases were coded for inte
Objectives. To study electrocardiogram (ECG) in relation to forensic diagnosis in young persons who suffered a sudden cardiac death (SCD) in Sweden during 1992-99. Design. A register study of a national database of forensic medicine in Sweden, selecting all cases of SCD 15-35 years of age. In this group, 12-lead ECGs and clinical data were searched for in military conscription and medical records.
About 10% of the patients with neurofibromatosis type 1 (NF1) develop malignant peripheral nerve sheath tumors (MPNSTs), accounting for half of all MPNST cases. Several nonrandom chromosomal aberrations have been found, but the target genes remain mostly unrecognized. Mutations in the NF1 and TP53 genes have been found in some MPNSTs, and recent data from mouse models support a synergistic effect
It is currently unclear how often genes that are mutated to cause rare, early-onset monogenic forms of disease also harbor common variants that contribute to the more typical polygenic form of each disease. The gene for MODY3 diabetes, HNF1 alpha, lies in a region that has shown linkage to late-onset type 2 diabetes (12q24, NIDDM2), and previous association studies have suggested a weak trend towa
Barnkonventionens artikel 3 och 12 ger uttryck för två centrala principer inom barnrätten, vilka även är fastställda i andra svenska lagar som föräldrabalken och lagen med särskilda bestämmelser om vård av unga. Principen om barnets bästa innebär att vid samtliga åtgärder som rör barn ska barnets bästa vara avgörande. Vid denna bedömning ska varje barn få chansen att uttrycka sina åsikter, vilka s
Buildings that are built and the asphalt that is used for the paving needs to be tested to see if they fulfill certain requirements and standards. These types of tests are performed at Peab’s technology centers/laboratories and it is in one of their labs in Helsingborg that the degree project has been executed. As soon as the laboratory gets a concrete sample, they are supposed to register it in t
The evolution of globular star clusters tells the history of the formation of galaxies, how stellar streams might have formed and how the future of the Universe might look like. Although the general theoretical background of the evolution is well understood, it is difficult to conduct accurate and realistic computer simulations of objects containing thousands of interacting bodies. This project in
The purpose of this study was to investigate men's experiences of being subjected to domestic violence by their female partners, identify the consequences of this violence, and analyse barriers to seeking help or leaving the relationship. The goal is to understand the nature of the violence and its impact on the men involved. Two theories have been used to analyse the results: Goffman’s theory
I uppsatsen undersöks lagregleringen om överskottsinformation vid användning av hemliga tvångsmedel i rättegångsbalken. Överskottsinformation är information som har med annat att göra än den utredning den hemliga tvångsåtgärden användes för. Lagändringen år 2023 innebär att informationen uttryckligen får användas för ”andra ändamål” än den ursprungliga utredningen vilket kan avse brott eller helt The essay examines the legal regulation on excess information when using secret measures of surveillance in the Code of Judicial Procedure . Excess information is information that pertains to matters other than the investigation for which the secret measure of surveillance was used. The 2023 legislative amendment explicitly allows the information to be used for “other purposes” than the original i
