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Life-threatening intracardiac and great vessels thrombi are rare in neonates. Recombinant tissue plasminogen activator (rTPA) is used in adults to stimulate fibrinolysis and facilitate thrombus resolution. Its use in neonates, along with heparin, remains controversial because of potential risk of serious bleeding. We aim to present our experience with the use of thrombolytic agents in seven neonat
Loop migration among birds is characterized by the spring route lying consistently west or east of the autumn route. The existence of loops has been explained by general wind conditions or seasonal differences in habitat distribution. Loop migration has predominantly been studied at the population level, for example by analysing ring recoveries. Here we study loop migration of individual marsh har
In aqueous systems with immobilized macromolecules, including biological tissue, the longitudinal spin relaxation of water protons is primarily induced by exchange-mediated orientational randomization (EMOR) of intra- and intermolecular magnetic dipole-dipole couplings. We have embarked on a systematic program to develop, from the stochastic Liouville equation, a general and rigorous theory that c
Reference panels from the 1000 Genomes (1000G) Project Consortium provide near complete coverage of common and low-frequency genetic variation with minor allele frequency ≥0.5% across European ancestry populations. Within the European Network for Genetic and Genomic Epidemiology (ENGAGE) Consortium, we have undertaken the first large-scale meta-analysis of genome-wide association studies (GWAS), s
To predict how organisms cope with habitat fragmentation we must understand their dispersal biology, which can be notoriously difficult. We used a novel, multi-pronged approach to study dispersal strategies in the endangered saproxylic hermit beetle Osmoderma eremita, exploiting its pheromone system to intercept high numbers of dispersing individuals, which is not possible with other methods. Mark
The vast majority of patients with primary dystonia are adults with focal or segmental distribution of involuntary movements. Although approximately 10% of probands have at least one first- or second-degree relative with dystonia, large families suited for linkage analysis are exceptional. After excluding mutations in known primary dystonia genes (TOR1A, THAP1, and CIZ1), whole-exome sequencing id
Bacterial colonization of the lower respiratory tract is frequently seen in COPD and may cause exacerbations leading to deterioration of the disease. An important part of the innate lung immunity is antimicrobial peptides, not least the cathelicidin hCAP-18/LL-37. Peptidylarginine deiminases (PADI) posttranslationally modifies proteins by converting cationic peptidylarginine residues to neutral pe
Nitrogen deposition and intentional forest fertilisation with nitrogen are known to affect the species composition of ectomycorrhizal fungal communities. To learn more about the mechanisms responsible for these effects, the relations between fungal growth, nitrogen uptake and nitrogen availability were studied in ectomycorrhizal fungi in axenic cultures and in symbiosis with pine seedlings. Effect
Fine-grained tills are a dominant feature of the drift geology of Sweden. Until recently their use in earthworks applications has been limited due to the plentiful supply of naturally occurring gravel and crushed rock, and their high sensitivity to moisture content change which often leads to the view that fine-grained tills are problem soils. Environmental and economic factors are, however, leadi
Myogenic activity, distention of the detrusor, and signals from the urothelium may initiate voiding. In the bladder, afferent nerves have been identified not only in the detrusor, but also suburothelially, where they. form a plexus that lies immediately beneath the epithelial lining. Extracellular adenosine triphosphate (ATP) has been found to mediate excitation of small-diameter sensory neurons v
Disturbance of ecosystems is a major factor in regional carbon budgets, and it is believed to be partly responsible for the large inter-annual variability of the terrestrial part of the carbon balance. Forest fires have so far been considered as the most important disturbance but also other forms of disturbance such as insect outbreaks or wind-throw might contribute significantly to the largely un
In areas where tectonics and weathering have hydrogeological significance, electrical methods can assist in mapping the subsurface. In this work, resistivity imaging was used to map fractures, faults and quartz veins emplaced in strongly weathered volcanic rocks. The aim was to map geological units related to the formation of groundwater systems in the Rio Artiguas basin, Nicaragua. Eight 2D resis
As the demand for eco-friendly alternatives to traditional plastics grows, Polyethylene Furanoate (PEF) emerges as a promising solution. Derived from renewable biomass sources, PEF embodies sustainability principles by reducing reliance on finite resources and minimizing environmental impact. PEF is synthesized from 2,5-furandicarboxylic acid (FDCA), a key monomer which upon polymerization has the
I Sverige finns många förorenade områden med klorerade lösningsmedel och Färgaren 3 i Kris-tianstad är ett av dem. Där har tidigare legat en kemtvätt som använt sig av PCE (Tetrakloreten), där spill och läck-age har förorenat stora delar av fastigheten. PCE och dess metaboliter har en tendens att förorena stora volymer, vilket gör dessa ämnen svåra att sanera. Detta mastersarbete inriktar sig på a
A large share of the existing building stock in Sweden originates from the so-called Million Building Programme, a large-scale construction wave between 1965 and 1974 to tackle the housing shortage at this time. Those buildings have very high energy demand and require renovation due to age and often neglected maintenance. The Swedish government’s long-term climate and energy goals are tied to an e
