Sökresultat

Context: SHBG regulates free sex steroid levels, which in turn regulate skeletal homeostasis. Twin studies have demonstrated that genetic factors largely account for interindividual variation in SHBG levels. Glucuronidated androgen metabolites have been proposed as markers of androgenic activity. Objective: Our objective was to investigate whether polymorphisms in the SHBG gene promoter [(TAAAA)(n

[NiFe] hydrogenases catalyse the reaction H2 <-> 2H(+) + 2e(-). Several states of the enzyme have been observed by spectroscopic methods. Among these, the two most oxidized states, called the unready Ni-A and Ni-SU states, have been especially intriguing, because they take a much longer time to activate than the corresponding ready Ni-B and Ni-SI states. It has recently been suggested that the unr

Background: An allogeneic antitumour effect has been reported for various cancers. We evaluated the experience of allogeneic haematopoietic stem cell transplantation (HSCT) for renal cell carcinoma (RCC) in 124 patients from 21 European centres. Patients and methods: Reduced intensity conditioning and peripheral blood stem cells from an HLA-identical sibling (n = 106), a mismatched related (n = 5)

Affinity proteins were covalently immobilised on silicon microchips with overall dimensions of 13.1 x 3.2 mm, comprising 42 porous flow channels of 235 mum depth and 25 pm width, and used to develop microfluidic immunosensors based on horseradish peroxidase (HRP), catalysing the chemiluminescent oxidation of luminol/p-iodophenol (PIP). Different hydrophilic polymers with long flexible chains (poly

Chagasin is a protein produced by Trypanosoma cruzi, the parasite that causes Chagas' disease. This small protein belongs to a recently defined family of cysteine protease inhibitors. Although resembling well-known inhibitors like the cystatins in size (110 amino acid residues) and function (they all inhibit papain-like (Cl family) proteases), it has a unique amino acid sequence and structure. We

The thesis has provided with systematic information about how people with schizophrenia live their everyday life, and the results have shown significant relationships between occupational perspectives and health. The thesis departed in two in-depth studies that concerned time use and occupational engagement in relation to what people with schizophrenia do in their everyday life, with whom they are

A novel immunoassay (PINC-ELISA) was designed using proteinase inhibitors of the cystatin superfamily (PINC) in the solid phase, to promote the selective capture of cysteine proteinases. The method was applied in the identification of papain-like antigens from parasitic protozoa. PINC of human origin, namely recombinant cystatin C (r-cystatin C) or low molecular weight kininogen were used in the a

Low molecular weight protein tyrosine phosphatase (LMW-PTP) dimerizes in the phosphate-bound state in solution with a dissociation constant of K-d = 1.5(+/-0.1) mM and an off-rate on the order of 10(4) s(-1).H-1 and N-15 NMR chemical shifts identify the dimer interface, which is in excellent agreement with that observed in the crystal structure of the dimeric S19A mutant. Two tyrosine residues of

Hollow fiber supported liquid membranes were applied for the passive extraction of phenoxy acid herbicides from water samples. Polypropylene hollow fiber membranes (240 mu m i.d., 30 mu m wall thickness, 0.05 mu m pore size, 30 cm length) were impregnated with 2.0% tri-n-octylphosphine oxide (TOPO) in di-n-hexyl ether in the pores of the fiber wall to form a liquid membrane. They were then filled

The human platelet cilostamide- and cGMP-inhibited cAMP phosphodiesterase (cGI-PDE) was rapidly purified approximately 19,000-fold to apparent homogeneity using single step affinity chromatography on the isothiocyanate derivative of cilostamide coupled to aminoethyl agarose. Within 24 h, 30 micrograms of enzyme protein was obtained from 20 ml of packed platelets. Vmax for cAMP and cGMP was 6.1 and

The idea of energy efficient, healthy buildings has existed since 1970s. However, a one-dimensional approach for many housing issues does not assure sustainability. Therefore, near the end of the 20th century, the built environment became a focus of attention within the environmental movement with wider focus on building certification schemes and sustainability issues such as interrelationships be

Föräldraskap, intervention och prevention vid barnövervikt/fetma hos förskolebarn med utgångspunkt ifrån ett barn- och familjepsykologiskt perspektiv är ämnet för denna uppsats. Psykologiska faktorer av betydelse för barns ätande, matens betydelse i familjen, föräldrastress kopplad till barns ätande, liksom tidpunkt och inriktning ifråga om intervention och prevention är ämnen som belyses och diskParenting, intervention and prevention of pediatric overweight/obesity in preschool children from a psychological, child-and family oriented perspective is the subject in this paper. Psychological factors of importance for children's eating, the importance of food in the family, parental stress related to children's eating, timing and focus in intervention and prevention are subjects, high

Problem/Bakgrund: I dagens moderna samhälle tillbringas allt mer tid till att vara verksam inom sociala medier. Bloggar som dagligen besöks av unga flickor är ett sätt att se hur andra har det vilket influerar dem till att vilja leva ett problemfritt liv och därför är det intressant att titta närmare på om det påverkar deras identitetsskapande. Syfte: Syftet är att undersöka om unga flickors ident

The comfortable garment is about creating a comfortable experience with all that it implies, both physiologically and psychologically. The project describes the interaction between expectations and needs, in and across situations, in order to be and feel prepared, relaxed, and while still well dressed. The Expectation of this project is that it should be an eye opener to take get new knowledge abo

Bakgrund. Varje år drabbas omkring 25 000 personer i Sverige av stroke. Individer som drabbats av stroke får oftast funktionsnedsättningar som orsakar aktivitetsbegränsning i vardagslivet. Syfte. Syftet med studien var att undersöka vilka erfarenheter och upplevelser strokedrabbade personer har av förändringar i vardagliga aktiviteter.Metod. Studien genomfördes som en kvantitativ metod där instrum

Under de senaste 100-200 åren har tall (Pinus sylvestris) etablerats på många sydsvenska mos- sar. Eftersom tall trivs i relativt torra och näringsrika miljöer, ger detta en indikation på att grundvattennivån i mos- sarna har sänkts. Tre mossar i Kronobergs län, Småland, har valts ut för en dendrokronologisk och torvstratigrafisk undersökning för att se om det finns ytnära torvlager som vittnar omScots pine (Pinus sylvestris) can be found growing in many raised bogs in Småland, south Sweden, and these trees have been established during the last 100-200 years. Because pine prefers a relatively dry environment rich in nutrients, its presence indicates a lowering of the groundwater table. Three bogs in south Sweden were in- vestigated with dendrochronologic and peat stratigraphic methods to d