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BACKGROUND: Cerebral endothelial dysfunction occurs in a spectrum of neurodegenerative diseases. Whether biomarkers of microvascular endothelial dysfunction can predict dementia is largely unknown. We explored the longitudinal association of midregional pro-atrial natriuretic peptide (MR-proANP), C-terminal endothelin-1 (CT-proET-1) and midregional proadrenomedullin (MR-proADM) with dementia and s
The aim of this thesis is to develop statistical models to reconstruct past land cover composition and human land use based on fossil pollen records over Europe for different time periods over the past 6000 years. Accurate maps of past land cover and human land use are needed when studying the interaction between climate and land surface, and the effects of human land use on past climate. Existing
In the wake of the arrival of cloud computing, future applications are poised to become more resilient and adaptive by embracing elasticity in an osmotic manner. Although cloud computing is a strong attractor for application developers, thereare still unconquered performance frontiers. Latency-sensitive and missioncritical applications make up a significant portion of all software systems, and the
1. IntroductionThe demand for efficient oil-water separation is driven by the tightening of discharge limits for e.g. produced water in the oil and gas industry, process water in the petrochemical industry and bilge water in the marine industry. The global produced water production alone is over 71 billion bbl/a – 8.4 billion m3/a [1]. Among the different technologies, particularly ultrafiltration
Alla ryggradsdjur har ett immunförsvar vars funktion är att skydda oss mot mikroorganismer som kan orsaka sjukdom, såsom bakterier och virus. Dessa sjukdomsframkallande ämnen kallas patogener. Immunförsvaret behöver kunna skilja mellan proteiner som kommer från den egna kroppen och från patogener. Molekylerna som kodas av gener i major histocompatibility complex (MHC) har en viktig del i denna igeThe function of the vertebrate immune system is to enable recognition and elimination of microorganisms that can cause harm (pathogens). A key component in adaptive immunity is the major histocompatibility complex (MHC) that codes for molecules with antigen presentation function. There are two main types of MHC molecules, class-I (MHC-I) and class-II (MHC-II) and the focus of my thesis has been MH
Abstraktinlämning NutritionGastrodagarna-1027Fortsatta erfarenheter av teduglutidbehandling vid extrema kort tarm syndrom i skåne och blekinge.Å Nilsson* 1, G Hoffmann2, M Söderholm3, L Zhou11Gastroenterologisektionen, Skånes Universitetssjukhus, Lund, 2Medicin, Gastroenterologi, Centralsjukhuset, Kristianstad, 3Kirurgiska Kliniken, Blekingesjukhuset, Karlskrona, SverigeBakgrund: Teduglutid (Reves
Epithelial–mesenchymal transition (EMT) is a cellular process during which epithelial cells acquire mesenchymal phenotypes. Cancer cells undergo EMT to acquire malignant features and TGF-β is a key regulator of EMT. Here, we demonstrate for the first time that TGF-β could elicit EMT in a mouse lung adenocarcinoma cell line. TGF-β signaling activation led to cell morphological changes corresponding
BACKGROUND: The aim was to investigate whether adding a reinforced tension-line (RTL) suture to a standard 4 : 1 small-bite closure would reduce the incidence of incisional hernia after colorectal cancer surgery.METHODS: Patients aged at least 18 years, who were scheduled for elective colorectal cancer surgery through a midline incision at two Swedish hospitals (2017-2021), were randomized in a 1
Denna artikel innehåller en analys av samtliga rapporter från Statens offentliga utredningar (SOU), 1945-89. Analysen applicerar metoder inom digital humaniora och inkluderar forskning gjort i en Jupyterlabbmiljö som utvecklats på Humlab på Umeå universitet. Artikeln är ett resultat av forskningsprojektet Välfärdsstaten analyserad, som ämnar att digitalisera litteratur, arbetar med datasäkring av In 2015 the National Library of Sweden finished digitising all Governmental Official Reports (SOU) from 1922 to 1999. Traditionally, SOU reports – and work performed within different governmental committees – were tasked with preparing the Swedish government for apt and rational decision-making. The range of subjects covered by governmental committees and SOU reports basically includes every area
Background: Optimisation of dopaminergic therapy may alleviate fluctuation-related pain in Parkinson’s disease (PD). Opicapone (OPC) is a third-generation, once-daily catechol-O-methyltransferase inhibitor shown to be generally well tolerated and efficacious in reducing OFF-time in two pivotal trials in patients with PD and end-of-dose motor fluctuations. The OpiCapone Effect on motor fluctuations
Cerebral accumulation of amyloid-β is thought to be the starting mechanism in Alzheimer's disease. Amyloid-β can be detected by analysis of cerebrospinal fluid amyloid-β42 or amyloid positron emission tomography, but it is unknown if any of the methods can identify an abnormal amyloid accumulation prior to the other. Our aim was to determine whether cerebrospinal fluid amyloid-β42 change before am
OBJECTIVES: To elucidate antibody responses after the second and third dose of COVID-19 vaccine in patients with inflammatory rheumatic diseases (IRD) treated with biologic/targeted disease modifying anti-rheumatic drugs (b/ts DMARDs).METHODS: Antibody levels to antigens representing spike full length protein and spike S1 were measured before vaccination, 2-12 weeks after the second dose, before a
High-order harmonic generation (HHG) is a highly nonlinear optical process in which extreme ultraviolet (XUV) radiation is generated due to the interaction of an intense laser field with atoms. This process enables the production of high harmonics, which would not be achieved with standard nonlinear media. The utilization of two-color laser fields (formed by combining a fundamental field with one
This thesis investigates principal terms that are pertinent specifically to the visual character of architecture. In common terminology such as order, complexity, variation, monotony, and contrast. By surveying recent public debates it is deduced that both laymen and professionals lack the sufficient language to establish common ground. By a doctor-patient metaphor it follows that no remedy can be
Problem definition: The increasingly informed customer will lead to an even greater demand for expertise and knowledge of marketers. Firms need to find new ways to utilize the informed customer as a co-creator of value by more proficiently analyzing behavior, both online and offline. An uncertainty lies in to which extent the operational standards of KIBS firms translate to their marketing and sal
Understanding and quantifying the global methane (CH4) budget is important for assessing realistic pathways to mitigate climate change. Atmospheric emissions and concentrations of CH4 continue to increase, making CH4 the second most important human-influenced greenhouse gas in terms of climate forcing, after carbon dioxide (CO2). The relative importance of CH4 compared to CO2 depends on its shorte
Pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension are rare conditions that require complex interventions by multidisciplinary teams. The European Society of Cardiology (ESC)/the European Respiratory Society (ERS) 2015 guidelines included recommendations for pulmonary hypertension (PH) referral centers including minimum number of patients, staff, facilities, and netw
The project has been developed from a proposal made by RegionService (technical real estate for Region Skåne) and based on the replacement of light fixtures from fluorescent lamps to white LEDs (Light Emitting Diodes) in some hallways in Helsingborgs Lasarett (The Hospital in Helsingborg). The results turned out to be positive and further replacement were made in nearby buildings as well. My part
