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Sitagliptin has been suggested as a treatment option for older adults with type 2 diabetes (T2D). However, no randomized controlled trial has been performed to evaluate the efficacy and safety of sitagliptin treatment in older Japanese patients with T2D. The STREAM study was a multicenter, open-label, randomized controlled trial. T2D outpatients aged 65-80 years with moderately controlled glycemic
Rapporten behandlar vidhäftning mellan in-situ-gjutna betongplattor, vilka används vid etappvis schaktning, och lerbotten i schakt. Huvudsyftet är att utreda vilken vidhäftning som verkar mellan materialen då betongen blir utsatt för skjuvning på grund utav tryck från sponten. Samt om brott går i kontaktytan mellan materialen eller i något av de två materialen samt hur detta sammanfaller med dagen
Life at a music festival can be both a blessing and a curse. It creates a feeling of escaping reality into euphoric happiness and freedom that only music festivals can bring. But one thing can drastically change this mood and make the living at the festival quite miserable – the weather. Rain as well as too high or low temperatures contribute to this negative change of mood. The festival chosen fo
Denna uppsats har som huvudsakliga frågeställning att besvara frågan om hur svensk historia gestaltas och brukas i populära memes på internationella forum, och varför den gestaltas och brukas på dessa sätt. Uppsatsen kommer fram till att den mest förekommande aspekten av svensk historia är vikingatiden, följt av 1900-talets utrikespolitik, stormaktstiden och kontemporär svensk kulturhistoria. Denn
In recent years, Iceland has experienced a growing demand for residential housing and the average square-meter price for apartments and single-family homes in the Capital Region has almost doubled between 2010 and 2019. Property sales in Iceland are most commonly intermediated by real estate brokers and the sales process stands in contrast to other Nordic countries, since it involves a bidding pro
Breast cancer is the most common cancer type among women. The 5-year survival rate for invasive breast cancer is generally good at approximately 80-85%, however it is not uncommon for late recurrences to develop – the relative survival at 15 years is approximately 60%, in contrast to for example uterine cancer where the 5-year is about 80% and very few late deaths occur (80% survival at 15-years).
Plant-insect interactions play a crucial role in the evolution of the coevolving web of life, shaping local interaction networks and moulding the diversity and the evolutionary history of two of the most diverse groups of organisms on earth. The interaction between Lithophragma bolanderi (Saxifragaceae), which presents a geographic mosaic of ploidy levels, and the pollinating floral parasite Greya
Sweden’s substantial building stock from the million programs is in need of renovations. These residential buildings were built without major attention to energy demand or architectural aesthetics. Until now, property owners have hesitated to carry out energy renovations due to the investment cost. The aim of this master thesis was to propose an energy-efficient renovation procedure whilst takin
The NEO model, developed by Lindström (2019) for paperboard, is a non-linear material model that utilizes empirically based constitutive relations with switches to mimic elastic-plastic responses. Due to the explicit definition of the constitutive relations, the NEO model does not require a constitutive equilibrium loop. This, in addition to modeling flexibility from the switches, poses the NEO mo
För att utöka biogasproduktionen i Västra Götalandsregionen (VGR) kan restströmmar från jordbrukssektorn fungera som en storskalig leverantör av biomassa. Produktionen av biogas minskar beroendet av fossila bränslen och rötresten som bildas kan också återföras till jordbrukssektorn, vilket skapar ett slutet kretslopp. I detta examensarbete granskades utökningen genom en kartläggning av biogasproduTo expand the biogas production in Region Västra Götaland (RVG), residual streams from the agricultural sector can function as a large-scale supplier of biomass. The production of biogas decreases the dependence of fossil fuels and the digestate that is formed can also be returned to the agricultural sector, creating a closed loop. The expansion was assessed in this thesis by the investigation of
Abstract The idea of the spread of life through the galaxy is, in most minds, considered science fiction. Yet, scientists argue that most galaxies have had more than enough time for civilisation development and space travel. In this thesis I simulate how civilisations can spread through the galaxy via close encountering stars, assuming they travel at sub-relativistic speeds. A defined region arou
In approximately 70% of individuals infected with HIV-1 subtype B, the virus switches coreceptor use from exclusively CCR5 use (R5 virus) to either inclusion of or exclusively CXCR4 use (X4 virus) during infection. This switch is associated with an accelerated loss of CD4(+) T-cells and a faster progression to AIDS. Despite intensive research, the mechanisms responsible for coreceptor switch remai
INTRODUCTION Stroke is a serious neurological disease which may lead to death and severe disability [1, 2]. There are two major types of stroke: ischemic and hemorrhagic stroke. Both are associated with disruption of blood flow to a part of the brain with rapid depletion of cellular energy and oxygen, resulting in ionic disturbances and eventually neuronal cell death [3]. The pathologic process t
Prostate-specific antigen (PSA) and human glandular kallikrein 2 (hK2) are secreted by the prostate into seminal plasma and through leakage into blood. This leakage increases rapidly in prostate disease, and PSA is used worldwide as a marker of prostate cancer. PSA is activated in vitro by hK2, and cleaves the semenogelins in semen, which releases motile sperm, and low levels of PSA have been asso
The aim of this thesis was to test a tool for assessing insomnia symptoms in elderly persons and to investigate late-life insomnia in terms of associated factors and evidence of non-pharmacological interventions in healthcare settings. Data were collected by means of a systematic literature search (Study I), questionnaires (Studies II-III), interviews and observations (Study IV). The results from
Three major cellulases, cellobiohydrolase I and II (CBH I and II) and endoglucanase II (EG II) of Trichoderma reesei have been purified by ion-exchange chromatography in an FPLC system. Microcrystalline cellulose (Avicel) was hydrolysed by the single enzymes and by equimolar mixtures of CBH I-CBH II and CBH I-EG II. Enzyme adsorption was followed indirectly by selectively quantifying the en
Popular Abstract in Swedish Introduktion: Validitet handlar enkelt uttryckt om överensstämmelse med sanningen eller exempelvis om ett instrument mäter det som är avsett. Validitet kan också ses som ett mer komplext begrepp, innefattande aspekter som nytta, relevans, värderingar och sociala konsekvenser. Validitet förutsätter reliabilitet som är ett mått på tillförlitlighet, noggrannhet eller reproAbstract Introduction: Validity is important at different levels in psychiatry. Valid structured instruments are important aids in screening and diagnostics, in both research and clinical practice. An aim of the diagnostic procedure is to yield valid diagnoses. Ultimately, the validity of structured instruments (non-empirical) and clinical diagnoses depends on the validity of the diagnostic class
Organic farming may contribute substantially to future agricultural production worldwide by improving soil quality and pest control, thereby reducing environmental impacts of conventional farming. We investigated in a comprehensive way soil chemical, as well as below and aboveground biological parameters of two organic and two conventional wheat farming systems that primarily differed in fertiliza
Objectives: To assess immunohistochemical (IHC) stains differentially expressed between different types of lung cancer. Methods: We evaluated 16 different IHC stains in 209 prospectively included, surgically treated primary lung cancers, including 121 adenocarcinomas, 65 squamous cell carcinomas, 15 large-cell carcinomas, 5 adenosquamous carcinomas, 2 sarcomatoid carcinomas, and 1 small-cell carci
