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Chitosan does not inhibit enzymatic action of human pancreatic lipase in Langmuir monolayers of 1,2-didecanoyl-glycerol (DDG)

In this study, we tested the hypothesis according to which chitosan reduces lipid digestion by blocking the access of lipases to ingested fat. Because lipase action takes place mostly at interfaces, we produced Langmuir films of 1,2-didecanoyl-glycerol (DDG), which is the substrate for human pancreatic lipase (HPL). The experimental assays were carried out in acidic medium, at pH 3.0, to ensure th

Actinide-only and full burn-up credit in criticality assessment of RBMK-1500 spent nuclear fuel storage cask using axial burn-up profile

Safe long-term storage of spent nuclear fuel (SNF) is one of the main issues in the field of nuclear safety. Burn-up credit application in criticality analysis of SNF reduces conservatism of usually used fresh fuel assumption and implies a positive economic impact for the SNF storage. Criticality calculations of spent nuclear fuel in the CONSTOR® RBMK-1500/M2 cask were performed using pre-generat

Multi-centre evaluation of accuracy and reproducibility of planar and SPECT image quantification : An IAEA phantom study

Accurate quantitation of activity provides the basis for internal dosimetry of targeted radionuclide therapies. This study investigated quantitative imaging capabilities at sites with a variety of experience and equipment and assessed levels of errors in activity quantitation in Single-Photon Emission Computed Tomography (SPECT) and planar imaging. Participants from 9 countries took part in a comp

Using standard microbiome reference groups to simplify beta-diversity analyses and facilitate independent validation

Motivation: Comparisons of microbiome communities across populations are often based on pairwise distance measures (beta-diversity). Standard analyses (principal coordinate plots, permutation tests, kernel methods) require access to primary data if another investigator wants to add or compare independent data. We propose using standard reference measurements to simplify microbiome beta-diversity a

Living on the Edge: Poverty, Pipes and the Question of Home

In the rush of urban growth, a fractured reality unfolds in Metro Manila, Philippines: one side is a booming, ever-evolving metropolis, while the other is a flood of migrant workers, the unemployed, and the homeless. Slums have even become a luxury few can afford, where even securing a place to live means waiting in line. When slums are a dream out of reach, and space for survival is stretched t

Recognized but harder to integrate : An eye-tracking study of French gender-fair forms during reading

Over the last decades, linguistic gender-fair forms have become increasingly used by individuals and official institutions. In the French-speaking sphere, this has led to heated discussions among politicians and other stakeholders, some of which claim that these forms render texts illegible and inaccessible to the greater public. However, the processing of gender-fair forms in reading has been the

Biomarker profile and disease burden associated with intermittent and long-term oral corticosteroid use in patients with severe asthma prior to biologic initiation in real-life (STAR)

Background: Asthma characterization using blood eosinophil count (BEC) (among other biomarkers and clinical indices) is recommended in severe asthma (SA), but the masking effect of oral corticosteroids (OCS), makes this challenging. Aim: Our aim was to explore the effect of OCS use (both intermittent [iOCS] and long-term [LTOCS]) prior to biologic initiation on SA phenotype and biomarker profile i

Changes of Grassland Rain use efficiency and NDVI in Northwestern China from 1982 to 2013 and its response to climate change

The grasslands in arid and semi-arid regions rely heavily on the use of rain, thus, improving rain use efficiency (RUE) is essential for securing sustainable development of grassland ecosystems in these areas with limited rainfall. In this study, the spatial and temporal variabilities of RUE for grassland ecosystems over Northwestern China during 1982-2013 were analyzed using the normalized differ

Association between occurrence of urinary bladder cancer and treatment with statin medication

Objective: The incidence of urinary bladder cancer (UBC) has increased in Sweden despite decreased smoking, indicating that other factors might be associated. The increased use of statin medication for elevated blood lipids might be one such influencing factor. The aim of the present study was to assess whether statins are afflicted with an increased incidence of UBC. Material and methods: Data fr

Is there a weekend effect in surgery for type A dissection? - Results from the NORCAAD database

BACKGROUND: Aortic dissection type A requires immediate surgery. In general surgery populations, patients operated during weekends have higher mortality rates compared to patients operated on weekdays. The weekend effect in aortic dissection type A has not been studied in detail.METHODS: The Nordic Consortium for Acute Type A Aortic Dissection (NORCAAD) registry includes patients (N=1,159) who und

Population-based primary HPV mRNA cervical screening compared with cytology screening

Primary HPV screening for cervical cancer by HPV mRNA testing (Aptima)was implemented in January 2017, for women ≥30 through 70 years, in the Region of Skåne, Sweden. HPV positive samples underwent cytology assessment, and women with any degree of abnormal cytology were referred for colposcopy. The aim was to audit the primary HPV screening program, by comparing the cytology results to those of co

Measurement of phospholipid fatty acids at picomolar concentrations in biofilms and deep subsurface sediments using gas chromatography and chemical ionization mass spectrometry

Examination of ester-linked phospholipid fatty acids (PLFA) have provided a means to characterize the community structure of microbial assemblies. Attempts to analyze such acids at low picomolar levels in environmental samples by gas chromatography and chemical ionization mass spectrometry (CIMS) using positive or negative ion detection, showed that the limit of detection (LOD) was mainly dependen

Much Ado about Nothing : Gender Research in Journals during the last 30 years

The paper accounts for the extent to which gender research is represented in leading archaeological journals throughout the 1980s to the present through the database Arts & Humanities Citation Index (ISI). The paper regards gender research as including gender, feminisms, masculinities,queer, intersectionality and embodiment. It is concluded that gender research, despite its alleged significanc