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Thee three-dimensional structure of calcium-loaded regulatory, i.e. N- terminal, domain (1-91) of human cardiac troponin C (cNTnC) was determined by NMR in water/trifluoroethanol (91:9 v/v) solution. The single-calcium-loaded cardiac regulatory domain is in a 'closed' conformation with comparatively little exposed hydrophobic surface. Difference distance matrices computed from the families of Ca2+

L-lactate dehydrogenase (LDH) from Bacillus stearothermophilus is a redox enzyme which has a strong preference for NADH over NADPH as coenzyme. To exclude NADPH from the coenzyme-binding pocket, LDH contains a conserved aspartate residue at position 52. However, this residue is probably not solely responsible for the NADH specificity. In this report we examine the possibilities of altering the coe

Trust within teams is a central performance driver in product innovation. In this paper, we examine the antecedents to and performance implications of trust in firms engaged in radical innovation compared to those working towards incremental innovations. Our findings suggest that systematic processes and structures are significantly linked to trust in firms conducting radical innovation, but not s

With a high share of motor vehicles yielding to crossing cyclists, cyclists’ waiting time decreases and their level of service increases. The main aim of this paper is to study how this propensity to yield is connected to the traffic safety situation for cyclists at cycle crossings in a Swedish context. In a previous study, motor vehicle drivers’ yielding behaviour was studied at 65 cycle crossing

During epididymal maturation, sperm acquire the ability to swim progressively by interacting with proteins secreted by the epididymal epithelium. Beta-defensin proteins, expressed in the epididymis, continue to regulate sperm motility during capacitation and hyperactivation in the female reproductive tract. We characterized the mouse beta-defensin 41 (DEFB41), by generating a mouse model with iCre

Mutations in DKC1, encoding for dyskerin, a pseudouridine synthase that modifies rRNA and regulates telomerase activity, are associated with ribosomal dysfunction and increased cancer susceptibility in the human syndrome, X-linked dyskeratosis congenita (X-DC). In a mouse model for X-DC, impairments in DKC1 function affected the translation of specific mRNAs harboring internal ribosomal entry site

What is the relationship between ballot reforms and electoral malpractice? This article contributes to the growing comparative politics literature on the causes of election fraud in democratizing countries using the case of the 19th-century United States. We examine the adoption of the Australian ballot and disenfranchisement laws, and estimate their effects on multiple types of election fraud. Us

BACKGROUND AND AIM: Many multilevel logistic regression analyses of "neighbourhood and health" focus on interpreting measures of associations (e.g., odds ratio, OR). In contrast, multilevel analysis of variance is rarely considered. We propose an original stepwise analytical approach that distinguishes between "specific" (measures of association) and "general" (measures of variance) contextual eff