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In this paper, the connection between the Matérn kernel and scale mixtures of squared exponential kernels is explored. It is shown that the Matérn kernel can be approximated by a finite scale mixture of squared exponential kernels through a quadrature approximation which in turn allows for (i) state space approximations of the Matérn kernel for arbitrary smoothness parameters using established sta
Background: Individuals undergoing radiation therapy for breast cancer frequently request information before, throughout and after the treatment as a means to reduce distress. Nevertheless, the provision of information to meet individuals needs from their level of health literacy is often overlooked. Thus, individuals information needs are often unmet, leading to reports of discontent. Internet an
HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) is the first member in a new family of protein-lipid complexes with broad tumoricidal activity. Elucidating the molecular structure and the domains crucial for HAMLET formation is fundamental for understanding its tumoricidal function. Here we present the low-resolution solution structure of the complex of oleic acid bound HAMLET, derived
The Early Toarcian Oceanic Anoxic Event (T-OAE) represents one of the major alterations of the carbon cycle of the Mesozoic period. Despite being globally recognized, and particularly represented within the Tethys realm, its expression in the sedimentary record is highly variable depending on the studied section, which suggests local environmental factors exert a major control on the resulting lit
A search for diphoton events with large missing transverse momentum has been performed using 1.07 fb(-1) of proton-proton collision data at root s = 7 TeV recorded with the ATLAS detector. No excess of events was observed above the Standard Model prediction and 95% Confidence Level (CL) upper limits are set on the production cross section for new physics. The limits depend on each model parameter
In the study of insect neuroanatomy, three-dimensional (3D) reconstructions of neurons and neuropils have become a standard technique. As images have to be obtained from whole-mount brain preparations, pigmentation on the brain surface poses a serious challenge to imaging. In insects, this is a major problematic in the first visual neuropil of the optic lobe, the lamina, which is obstructed by the
The results of a search for pair production of the lighter scalar partners of top quarks ((t) over bar (1)) in 2.05 fb(-1) of pp collisions at root s = 7 TeV using the ATLAS experiment at the LHC are reported. Scalar top quarks are searched for in events with two same flavour opposite-sign leptons (e, mu) with invariant mass consistent with the Z boson mass, large missing transverse momentum and j
Rational drug design is predicated on knowledge of the three-dimensional structure of the protein-ligand complex and the thermodynamics of ligand binding. Despite the fundamental importance of both enthalpy and entropy in driving ligand binding, the role of conformational entropy is rarely addressed in drug design. In this work, we have probed the conformational entropy and its relative contributi
Background: Since barrier protection measures to avoid contact with allergens are being increasingly developed, we assessed the clinical efficacy and tolerability of a topical nasal microemulsion made of glycerol esters in patients with allergic rhinitis. Methods: Randomized, controlled, double-blind, parallel group, multicentre, multinational clinical trial in which adult patients with allergic r
According to many scholars America's soft power is in decline, a power resource whose importance has been increasing in world politics. This makes it interesting to examine if there is a difference between how Democratic and Republican administrations wield their soft power. This thesis is a hypothesis-testing study and the purpose is to test the hypothesis that Democratic administrations, to
A search is performed for WH production with a light Higgs boson decaying to hidden-sector particles resulting in clusters of collimated electrons, known as electron-jets. The search is performed with 2.04 fb(-1) of data collected in 2011 with the ATLAS detector at the Large Hadron Collider in proton-proton collisions at root s = 7 TeV. One event satisfying the signal selection criteria is observe
This thesis is a case study of a Spanish castle called Aljafería. The objective of the study was to develop the mediation of this particular castle and to construct a research design that could be used to develop the mediation of other architectural heritage visitor attractions. The research design emerged during the course of the case study, using a grounded method perspective. The most dominant
The European Union’s (EU) ‘market-oriented’ approach to renewable energy development risks undermining the ability of individual citizens to meaningfully contribute to, and benefit from, a decentralised, localised, and decarbonised energy system. In spite of the EU’s ambition to involve local communities for co-driving a low-carbon energy transition, there is no comprehensive analysis uncovering t
Populärvetenskaplig sammanfattning Morgondagens energi Vind-, och vattenkraft tillsammans med solenergi är de enda energikällorna vi har som inte leder till avfall som ökar växthuseffekt eller avfall som vi inte kan göra oss av (från t ex kärnkraftverk). Men solpanelerna som finns idag för kommersiellt privat bruk ligger på en effektivitet kring 15%. Att utveckla nya molekyler som kan omvanlda solThe aim of the study was to theoretically investigate if a proton coupled electron transfer (PCET) was feasible for a molecular system consisting of a light harvesting complex, ruthenium(tris-2,`2-bipy)2+, with different organic moieties serving as PCET (proton coupled electron transfer) relays. These light harvesting complexes are also sometimes referred to as dyes. By studying the energy levels
This study aims to add new knowledge to our understanding of poverty as a multidimensional phenomenon and focuses on the links between poverty and gender norms and practices. The overall research question that this study is concerned with is about the effect of self-help group participation on women’s self-perceptions of options, their access to social, economic and cultural capital, and subsequ
The aim of this thesis is to present experiences and lessons learned from the initial implementation process of the rating system STARS at Washington University in St. Louis: mainly the strengths/opportunities can be used to overcome the weaknesses/threats that the STARS implementation may entail. Strengths and opportunities such as increased student involvement in processes such as assessing sust
BACKGROUND: Reports on perioperative complications after postchemotherapy retroperitoneal lymph node dissection (PC-RPLND) for nonseminoma germ cell tumour (NSGCT) are from experienced single centres, with a lack of population-based studies. OBJECTIVE: To assess the complications of bilateral and unilateral PC-RPLND. DESIGN, SETTING, AND PARTICIPANTS: A prospective, population-based, observational
The amyloid precursor protein intracellular domain (AICD), a cleavage product of amyloid precursor protein implicated in Alzheimer disease and amyloid lateral sclerosis, is a functionally important but structurally elusive intrinsically disordered protein. In this study, we investigate the conformational ensemble of a 35-residue AICD segment encompassing the conserved YENPTY motif using molecular
