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We investigated type 2 diabetes (T2D) genetic susceptibility via multi-ancestry meta-analysis of 228,499 cases and 1,178,783 controls in the Million Veteran Program (MVP), DIAMANTE, Biobank Japan and other studies. We report 568 associations, including 286 autosomal, 7 X-chromosomal and 25 identified in ancestry-specific analyses that were previously unreported. Transcriptome-wide association anal
In 1495, the royal Danish ship Gribshunden sank in the Baltic Sea, near the town of Ronneby. During archaeological excavations in 2019, a wooden barrel submerged inside the shipwreck revealed the almost complete and well-preserved remains of a sturgeon fish. In this paper, we present the find in terms of species identification, estimation of number of individuals, size reconstruction and butchery
The chemical composition of foraminiferal calcite is widely used for studying past environmental conditions and biogeochemistry. However, high rates of microbial organic matter degradation and abundant dissolved metal sources in sediments and pore waters may impede the application of foraminifera-based proxies due to formation of secondary carbonates or other authigenic minerals on and/or inside o
Background and purpose — The use of custom-made 3D-printed titanium implants for the reconstruction of large acetabular defects has been successively introduced in the last decade. In an observational cohort study we evaluated the agreement between preoperatively planned and actually achieved cup-cage position as well as 1-year follow-up migration of the cup-cage component. Patients and methods —
According to IPCC reports, global climate change is likely to be accompanied by a greater frequency, intensity, and duration of heat waves in urban areas. This is related to predicted and ongoing variation of atmospheric temperature and its association with the dynamical evolution of cities. Changes in the roughness pattern of the surface, wind intensity, soil available humidity and radiative prop
Primary immunodeficiencies (PIDs) are inherited disorders of the immune system with allogeneic hematopoietic stem cell transplantation (HSCT) as the only curative treatment in some of them. In case an HLA-matched donor is not available, HSCT from a haploidentical family donor may be considered. We compared the outcomes of HSCT from HLA-matched unrelated or related donors (MUDs or MRDs) and mismatc
We identify earnings impacts of exposure to an infant health intervention in Sweden, using individual-linked administrative data to trace potential mechanisms. Leveraging quasi-random variation in eligibility, we estimate that exposure was associated with higher test scores in primary school for boys and girls. However, only girls were more likely to score in the top quintile. Subsequent gains, in
The preservation of labile biomolecules presents a major challenge in chemistry, and deep eutectic solvents (DESs) have emerged as suitable environments for this purpose. However, how the hydration of DESs impacts the behavior of proteins is often neglected. Here, we demonstrate that the amino acid environment and secondary structure of two proteins (bovine serum albumin and lysozyme) and an antib
Background: Takotsubo syndrome (TS) is a life-threatening acute heart failure syndrome without any evidence-based treatment options. No treatment for TS has been examined in a randomized trial. Study design and objectives: BROKEN-SWEDEHEART is a multicenter, randomized, open-label, registry-based 2 × 2 factorial clinical trial in patients with TS designed to test whether treatment with adenosine a
Background: Acute ischemic lesions are challenging to detect by conventional computed tomography (CT). Virtual monoenergetic images may improve detection rates by increased tissue contrast. Purpose: To compare the ability to detect ischemic lesions of virtual monoenergetic with conventional images in patients with acute stroke. Material and Methods: We included consecutive patients at our center t
Background and purpose — The EQ-5D is a patient-reported outcome measure (PROM). To make priorities and allocate resources between patients and surgical procedures it is necessary to evaluate outcome differences, which is why comparing PROMs between registers is important. We compared EQ-5D data and the follow-up rate for selected diag-noses reported to Swedish orthopedic registers before and 1 ye
The rise of online brand communities has transformed consumer/brand interactions, thus affecting consumer engagement and its nomological network. However, scholarly understanding regarding the effect of consumer values on their online engagement remains tenuous. Addressing this gap, we conceptualize a model that attempts to understand the relative effect of consumers’ values (terminal and instrume
PurposeWe describe the design and implementation of the Malmö Breast ImaginG (M-BIG) database, which will support research projects investigating various aspects of current and future breast cancer screening programs. Specifically, M-BIG will provide clinical data to: 1. investigate the effect of breast cancer screening on breast cancer prognosis and mortality; 2. develop and validate the us
The chapter maps out the elite of the early Danish temperance movement and shows how distinct moral elites within the movement interpreted the cause according to their respective value frames while integrating the emerging disease frame of alcoholism. Theoretically, it argues for introducing the thus far estranged perspectives of elite studies and framing approaches to each other. The concept of m
BackgroundLeft ventricular (LV) lead position may be an important factor for delivering effective cardiac resynchronization therapy (CRT). We therefore aimed to evaluate the effects of LV lead position, stratified by native QRS morphology, regarding the clinical outcome.MethodsA total of 1295 CRT-implanted patients were retrospectively evaluated. LV lead position was classified as lateral, anterio
Background: Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is a rare and potentially life-threatening bleeding disorder of the fetus/newborn. Antibodies against human platelet antigen 1a (HPA-1a) are associated with the most frequent FNAIT cases. There are no approved therapies for FNAIT prevention or treatment. RLYB211 is a polyclonal HPA-1a hyperimmune IgG being developed to prevent FNAIT. O
Metal-halide perovskites (MHPs) are promising as active optoelectronic materials for a diverse range of devices. Anion exchange is a post-growth modification of MHP materials that allows tuning of the band gap and crystal structure by exposure to alternative halides, normally using solution methods. Here, low temperature gas-phase anion exchange for the conversion of CsPbBr3 nanowires (NW) into Cs
C4b-binding protein (C4BP) is a well-known regulator of the complement system that holds additional and important activities unrelated to complement inhibition. Recently, we have described a novel immunomodulatory activity in the minor C4BP(β-) isoform directly acting over inflammatory phagocytes. Here we show that incorporation of the β-chain to the C4BP α-chain oligomer interferes with this immu
