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The accumulation of tau abnormality in sporadic Alzheimer’s disease is believed typically to follow neuropathologically defined Braak staging. Recent in-vivo PET evidence challenges this belief, however, as accumulation patterns for tau appear heterogeneous among individuals with varying clinical expressions of Alzheimer’s disease. We, therefore, sought a better understanding of the spatial distri
As well as contributing to society, corporate social responsibility (CSR) initiatives have frequently been utilized by businesses to gain a competitive edge. Nevertheless, despite companies’ endeavors to leverage their CSR initiatives, limited stakeholder awareness of these efforts poses challenges to fully realize the strategic value of CSR. Hence, the primary objective of this study was to exami
Novel immunotherapies for cancer and other diseases aim to trigger the immune system to produce durable responses, while overcoming the immunosuppression that may contribute to disease severity, and in parallel considering immunosafety aspects. Interleukin-2 (IL-2) was one of the first cytokines that the FDA approved as a cancer-targeting immunotherapy. However, in the past years, IL-2 immunothera
Consumers are increasingly asked to “empty out their closets,” to “de-clutter” or in other ways detach themselves from the textile surplus of their wardrobes. In this article, fashion is examined as a process of detachment. Building on ethnographic wardrobe interviews, wardrobe clearances and group discussions with consumers, detachment is viewed as a fundamental, yet underexamined, process of fas
Cities, where human energy activities and greenhouse gas emissions are concentrated, contribute significantly to alleviating the impacts of global climate change. Utilizing the China Carbon Emissions Accounting Database (CEADs) to provide carbon dioxide emission inventories for urban areas in China at the prefecture level, this study closely examines the historical evolution trajectories of carbon
In recent years, the expansion of production incentives and evolving global filmmaking trends have intensified the complexities surrounding runaway production, particularly in and out of Scandinavia. This shift calls for a thorough examination of how production incentives are affecting Scandinavian screen industries as well as the broader history of runaway production. In my postdoctoral project,
We characterize the model spaces K in which functions with smooth boundary extensions are dense. It is shown that such approximations are possible if and only if the singular measure associated to the singular inner factor of is concentrated on a countable union of Beurling Carleson sets. In fact, we use a duality argument to show that if there exists a restriction of the associated singular measu
Despite the importance of SMEs for innovation activity, questions remain concerning the determinants of their innovative performance and the role of different types of collaboration and partners. The present paper empirically analyzes the role played by different types of R&D collaborations in the persistence of SME innovative performance. We used a longitudinal database to identify all the Sw
Kan en silkeshandske vara en symbol för makt? I denna tänkvärda volym samlas en grupp namnkunniga historiker för att ge perspektiv på överlappande frågor kring genus, materialitet och politik. Genom historiska fallstudier som sträcker sig från 1500-talet och fram i modern tid utforskar författarna brännpunkter i företeelser som diplomati, kvinnors inflytande och tillskrivandet av betydelse hos förCan a silk glove be an expression of power? In this carefully curated volume, internationally renowned historians have come together to explore the interconnected perspectives of gender, materiality, and politics. As the authors elaborate on these topics, the volume offers contributions covering a period from the sixteenth century to the present day, investigating political culture and diplomacy,
Human carbonic anhydrase II catalyzes the reversible reaction of carbon dioxide and water to form bicarbonate and a proton. His64-mediated proton shuttling between the active site and the bulk solvent is rate limiting. Here we investigate the protonation behavior of His64 as well as its structural and dynamic features in a pH dependent way. We derive two pK a values for His64, 6.25 and 7.60, that
The honeybee Apis mellifera, with a brain of only 960,000 neurons and the ability to perform sophisticated cognitive tasks, has become an excellent model in life sciences and in particular in cognitive neurosciences. It has been used in our laboratories to investigate brain and behavioural asymmetries, i.e., the different functional specializations of the right and the left sides of the brain. It
The focus of much sensory language research has been on vocabulary and codability, not how language is used in communication of sensory perceptions. We make a case for discourse-oriented research about sensory language as an alternative to the prevailing vocabulary orientation. To consider the language of sound in authentic textual data, we presented participants with 20 everyday sounds of unknown
Business angels are a vital source of capital for innovative start-up firms. However, many potentially attractive investment opportunities are rejected during the angel's decision-making process. Information asymmetry, risk and distrust in the relationship between the investor and the entrepreneur result in investment barriers. The concept of proximity has been proposed as a conceptual foundation
Social inclusion and the importance of work in developing countries has been an increasing topic of conversation during recent AIS conferences, and there are calls for research into ‘making a better world with ICT’. Trauth (2017) in her ‘Research Agenda for Social Inclusion in Information Systems’ states that “social inclusion in the information systems field is a research topic whose time has com
Small angle X-ray scattering has been proven to be a valuable method for accessing structural information below the spatial resolution limit implied by direct imaging. Here, we theoretically derive the relation that links the subpixel differential phase signal provided by the sample to the moments of scattering distributions accessible by refraction sensitive X-ray imaging techniques. As an import
ABC-stacked multilayer graphene (ABC-MLG) exhibits topological surface flat bands with a divergent density of states, leading to many-body instabilities at charge neutrality. Here, we explore electronic ordering within a mean-field approach with full generic treatment of all spin-isotropic, two-site charge density and spin interactions up to next-nearest-neighbor (NNN) sites. We find that surface
Context. Gaia Data Release 3 (Gaia DR3) contains the second release of the combined radial velocities. It is based on the spectra collected during the first 34 months of the nominal mission. The longer time baseline and the improvements of the pipeline made it possible to push the processing limit from GRVS= 12 in Gaia DR2 to GRVS= 14 mag. Aims. We describe the new functionalities implemented for
A search for resonances in events with at least one isolated lepton (e or μ) and two jets is performed using 139 fb −1 of s = 13 TeV proton–proton collision data recorded by the ATLAS detector at the LHC. Deviations from a smoothly falling background hypothesis are tested in three- and four-body invariant mass distributions constructed from leptons and jets, including jets identified as originatin
