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Human complement component C4 was irreversibly inactivated by low concentrations of methylamine at slightly alkaline pH. The inactivated C4 molecules lost the ability to bind to EAC1 cells but retained th capacity to participate in the formation of classical pathway C3 convertase in the fluid phase. 14C-methylamine was incorporated into the alpha-chain at a ratio of 1 mol methylamine per mol C4.

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Unanticipated procurement costs due to changes in input factors’ market prices and exchange rates are an increasing issue for manufacturers. A popular strategy is transferring these price increases to the supply chain. Based on 12 interviews and a follow-up study, we identified the main enablers for manufacturers to do so.

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The use of distributed development teams is becoming more common and for many good reasons. Some of the advantages are that it makes it possible to outsource parts of the development effort, gives access to a larger pool of talents and specialists, facilitates the integration of mergers and acquisitions, and allows for more flexibility in scaling up and down projects. However, distributed developm