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BACKGROUND AND OBJECTIVES: Degarelix is a gonadotropin-releasing hormone antagonist registered for the treatment of advanced hormone-dependent prostate cancer. Treatment causing androgen deprivation is associated with QT prolongation and this study investigated whether degarelix at supratherapeutic concentrations has an intrinsic effect per se on cardiac repolarisation and the QT interval.METHODS:
Background: Namibia has made significant gains in the fight against malaria, with a target of elimination by 2023. We examined the genotype and allele frequencies of glucose-6-phosphate dehydrogenase (G6PD) deficiency to inform decisions on primaquine use, as we recently detected clusters of Plasmodium ovale curtisi in Kavango. Methods: A multistaged cross-sectional sampling method was used to enr
Background: Traumatic brain injuries continue to be a significant cause of mortality and morbidity worldwide. Most traumatic brain injuries are classified as mild, with a low but not negligible risk of intracranial hemorrhage. To help physicians decide which patients might benefit from a computerized tomography (CT) of the head to rule out intracranial hemorrhage, several clinical decision rules h
Context: Large epidemiological studies often collect non-fasting samples, although the reliability of biomarkers may be uncertain. Objective: To explore the reliability and reproducibility of a single measurement of selected biomarkers in a sub-sample of the Malmö Diet and Cancer cohort. Methods: We estimated single- and average-measures intraclass correlation coefficients (ICC) for oxidized (ox)-
Here, we first present a follow-up to a previous work by our group on the problematic of molecular dynamics simulations of intrinsically disordered proteins (IDPs) [Henriques et al. J. Chem. Theory Comput. 2015, 11, 3420−3431], using the recently developed TIP4P-D water model. When used in conjunction with the standard AMBER ff99SB-ILDN force field and applied to the simulation of Histatin 5, our
This research report has two objectives, both focusing on the supply chain flows passing or crossing the Öresund maritime area. The first objective is to identify and describe the flows in Öresund and the risks for disturbances in those flows before and after the opening of the Öresund Link in July 2000. With the opening of the Öresund Link a new goods and passenger flow was created. As a resul
The N400 has been seen to be larger for concrete thanabstract words, and for pseudowords than real words. Using a word vectoranalysis to calculate semantic associates (SA), as well as ratings foremotional arousal (EA), and a measure of orthographic neighbourhood (ON), thepresent study investigated the relation between these factors and N400 amplitudes during a lexical decision task usingSwedish wo
The structural properties, and the intracrystalline swelling of Na+-, and Ca2+-montmorillonite (Na-, and Ca-mmt) have been investigated as an effect of decreasing the relative permittivity of the solvent, i.e. from water to ethanol (EtOH), utilizing the experimental techniques; small angle X-ray scattering (SAXS) and osmotic pressure measurements. The experimental data were compared with the conti
Neural networks designed for real-time object detectionhave recently improved significantly, but in practice, look-ing at only a single RGB image at the time may not be ideal.For example, when detecting objects in videos, a foregrounddetection algorithm can be used to obtain compact temporaldata, which can be fed into a neural network alongside RGBimages. We propose an approach for doing this, bas
Kainate-induced seizures result in hippocampal neurodegeneration and spatial learning deficits in rodents. Previous studies show that rofecoxib, a selective cyclooxygenase-2 inhibitor, protects against kainate-induced hippocampal cell death 3 days after seizures. Our aim was to determine whether rofecoxib attenuates visuospatial learning deficits and late neuronal death after kainate-induced seizu
Recent evidence suggested a weak relationship between alcohol consumption and pancreatic cancer (PC) risk. In our study, the association between lifetime and baseline alcohol intakes and the risk of PC was evaluated, including the type of alcoholic beverages and potential interaction with smoking. Within the European Prospective Investigation into Cancer and Nutrition (EPIC) study, 1,283 incident
The ability of state-of-the-art regional climate models (RCMs) to simulate the trends of intense cyclone activity in the Arctic is assessed based on an ensemble of 13 simulations from 11 models from the Arctic-CORDEX initiative. Some models employ large-scale spectral nudging techniques. Cyclone characteristics simulated by the ensemble in winter and summer are compared with the results from four
In the tropical moist semi-deciduous forests of West Africa, soil catenas with extremely gravel-rich soil horizons at the summits and upper slopes and largely gravel-free profiles at the lower slope are common. Previous investigations have suggested that these gravel layers are the result of macro-invertebrates mining of fine-grained soil m
Nine Ce ii lines have been identified and characterized within the spectral window observed by the Apache Point Observatory Galactic Evolution Experiment (APOGEE) survey (between λ1.51 and 1.69 μm). At solar metallicities, cerium is an element that is produced predominantly as a result of the slow capture of neutrons (the s-process) during asymptotic giant branch stellar evolution. The Ce ii lines
This study examines the interdependence between research and development (R&D) resources, coopetitive performance, and extent of cooperation in development-related standardization settings that involve network effects. Coopetitive performance is measured as the firm’s influence on the change process of standards. Cooperation is measured as the number of firm technology partners in influencing
