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Cancer presently represents a significant global health challenge, illustrated by the high incidence and mortality rates associated with lung and breast cancer. Technological advances and concerted large-scale initiatives have yielded vast amounts of cancer data to be used for research purposes. The objective of this thesis is to capitalize on the current state of the bioinformatics field to devel
Tumour-induced osteomalacia is caused by tumorous production of fibroblast growth factor 23 (FGF23) leading to urinary phosphate wasting, hypophosphataemia and decreased vitamin D activation. The resulting osteomalacia presents with muscle weakness and bone pain but progresses to multiple pathological fractures. Patients often remain undiagnosed for years with severe physical, psychological and ec
Protein aggregation is a key process in the development of many neurodegenerative disorders, including dementias such as Alzheimer's disease. Significant progress has been made in understanding the molecular mechanisms of aggregate formation in pure buffer systems, much of which was enabled by the development of integrated rate laws that allowed for mechanistic analysis of aggregation kinetics. Ho
Recent studies have explored the influence of obesity and critical illness on ciprofloxacin pharmacokinetics. However, variation across the subpopulation of individuals with obesity admitted to the intensive care unit (ICU) with varying renal function remains unexamined. This study aims to characterize ciprofloxacin pharmacokinetics in ICU patients with obesity and provide dose recommendations for
Objective: To translate and cross-culturally adapt the Stroke Self-Efficacy Questionnaire (SSEQ) from English to Swedish and to evaluate psychometric properties of the questionnaire. Methods: A cross-sectional study design, where the translation followed a process including initial translation, synthesis, backward translation, expert committee, and pretest. Content validity was assessed using Cont
Digitalization and emergence of new technologies including Artificial Intelligence has shaped new organizational principles for the functioning of economies and societies globally. Technology has also changed the landscape for taxation and interactions between tax administration and taxpayers. Recently various models of electronic reporting and invoicing, split-payment mechanisms as well electroni
Taking point of departure in two black dolls that once belonged to Sophie Christine Oxholm and to the family of Clara Asenath Schultz, the article explores aspects of childhood and childcare in colonial homes. Both girls grew up in the Danish West Indies in the nineteenth century and were cared for by African Caribbean nannies – the likely makers of the dolls. Drawing on historical and literary so
This article examines limits to per capita living space (i.e. living smaller and/or sharing living space) as a measure for achieving sufficiency in housing. It studies the acceptance, motivation and side-effects of voluntarily reducing living space in five European Union countries: Germany, Hungary, Latvia, Spain and Sweden. Insights are derived from an extensive collection of qualitative empirica
In power electronics, wide-bandgap materials such as GaN are used in diodes due to their ability to handle high currents and voltages. Metal contacts on p-doped GaN have difficulty obtaining low specific contact resistivity and the behaviour of an ohmic contact. In this report, different parameters were changed in the process to optimise the device. The parameters changed were the photoresist deve
This project explores how urban design can support a more inclusive, walkable and caring neighbourhood for older women in Copenhagen. Located in Refshaleøen, the project uses independently living women aged 65–75 as a critical lens for rethinking future urban development. The proposal focuses on everyday needs often overlooked in conventional planning, including slower movement, rest, safety, acc
This thesis is an experimental study that explores the role correlated disorder plays in the ground state selection of quantum magnetic materials. Whilst magnetic materials with conventional long-range magnetic orderings give rise to magnetic Bragg peaks that can be understood through average structure methods, the unconventional correlated short-range orderings of quantum magnetic materials give
In this episode, we speak to Kees van der Geest, academic officer and Head of Environment and Migration section at the UN University, and Linnéa Nordlander, Assistant Professor of human rights and sustainability at the University of Copenhagen.
The global decline of seagrass meadows has increased the need for effective restoration strategies, yet recovery is often limited by physical environmental stressors. This thesis investigates the hydrodynamic thresholds influencing seagrass seedling survival and recruitment along the Adelaide coastline in Gulf St. Vincent, South Australia. The study focuses on two sites with similar environmental
This thesis investigates simulating X-ray computed tomography with two primary objectives: developing a virtual representation of an X-ray computed tomography scanner and generating labelled synthetic training data for deep learning-based fibre segmentation. A simulation pipeline to generate X-ray projections based on the Beer-Lambert law was developed using the open-source framework gVirtualXray.
