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Ligand selectivity among the highly conserved galectins has been an ever-challenging objective. For galectin-8, a protein prevalent in both pathology and tissue distribution, we report phthalazinone-galactals that show excellent selectivity for the galectin-8N-terminal domain. A dissection of structure–activity relationships of the phthalazinone and an extensive molecular dynamics meta-analysis ac

This study examines the first-hand sources of Kemalism to understand how and to what extent the French Revolution inspired the Kemalist elite and influenced Kemalism during the early republican period. In the literature, there is a general perception that the French Revolution and Jacobinism were highly influential on the Kemalists, but this perception mainly depends on broad interpretations witho

Viljan att skydda växter och djur får ibland orimliga effekter. Det skriver flera företrädare för Moderaternas arbetsgrupp för en kommande miljöpolitik på DN debatt.Farlig polariseringDe tar bland annat upp viktiga frågor om ”människans plats i naturen”. Men konflikten mellan utveckling och miljö är en återkommande missuppfattning. Frågan om naturvården främst bör utgå från människans eller nature

This chapter introduces the British MPs’ expenses scandal: its origins, evolution and consequences. We argue that despite some early predictions, the scandal was limited in its impact: the purported ‘revolution’ never occurred. We briefly review the comparative literature on the political impact of scandal, which illustrates why the effects of scandals are usually limited and reasons why voters ma

A search is presented for a heavy resonance Formula Presented decaying into a Standard Model Higgs boson Formula Presented and a new particle Formula Presented in a fully hadronic final state. The full Large Hadron Collider run 2 dataset of proton-proton collisions at Formula Presented collected by the ATLAS detector from 2015 to 2018 is used and corresponds to an integrated luminosity of Formula

Miljöersättningar i landsbygdsprogrammet kritiseras för att inte vara kostnadseffektiva eller attraktiva för många jordbrukare,samt för att inte ta vara på jordbrukarnas kompetens och kreativitet för att lösa miljöproblem. Problemen beror i hög grad på attersättningen betalas ut oavsett storleken på miljöeffekten, bara den avtalade åtgärden utförs. Utvecklingen av ett effektivare system för miljöe

This article describes and critically examines the challenging task of compiling The London–Lund Corpus 2 (LLC–2) from start to end, accounting for the methodological decisions made in each stage and highlighting the innovations. LLC–2 is a half-a-million-word corpus of contemporary spoken British English with recordings from 2014 to 2019. Its size and design are the same as those of the world's f

Aim: The Eurasian otter (Lutra lutra) is a flagship species for global freshwater ecosystems. As one of the most widely distributed Palearctic mammals, the otter used to inhabit most provinces in China. However, after decades of relentless hunting and habitat degradation, the Sanjiangyuan Region is now one of last strongholds for this species in China. Currently, there still remains an enormous kn

Aims/hypothesis: The aim of this work was to study the incidence over time of lower extremity amputations and determine variables associated with increased risk of amputations in people with type 1 diabetes. Methods: Individuals with type 1 diabetes registered in the Swedish National Diabetes Registry with no previous amputation from 1 January 1998 and followed to 2 October 2019 were included. Tim

We provide a statistically significant observation of the elusive Odderon exchange, based on novel and model-independent analysis of the scaling properties of the differential cross sections of elastic pp and pp scattering in the TeV energy range. We report the statistical significance of the observed Odderon signal at the level of 6.26 σ.

One important feature closely connected with the Baroque is elaborate word play, such as the frequent use of anagrams. Taking Nicolaus Reusner’s Anagrammatographia and Guillaume Leblanc’s work on anagram poetry as our point of departure, we discuss the use of anagrams and acrostics in the works of the Danish poet Henrik Albertsen Hamilton and the Swedish poet Georg Stiernhielm. We take a closer lo

Chemical characterization of the Galactic center is essential for understanding its formation and structural evolution. Trends of alpha (α) elements, such as magnesium, silicon, and calcium, serve as powerful diagnostic tools, offering insights into star formation rates and gas-infall history. However, high extinction has previously hindered such studies. In this study, we present a detailed chemi

INTRODUCTION: Esophageal squamous cell carcinoma (ESCC) carries a poor prognosis, but earlier tumor detection would improve survival. We aimed to develop and externally validate a risk prediction model based on exposure to readily available risk factors to identify high-risk individuals of ESCC.METHODS: Competing risk regression modeling was used to develop a risk prediction model. Individuals' ab

This paper discusses how archaeologists might investigate issues of poverty by focusing on poorhouses. The poor and deprived are rarely prominent objects in archaeological research, probably because archaeologists find it difficult to relate to a concept such as poverty. At the same time, there is material culture that can be clearly linked to poverty. One such materiality is poorhouses. While the

Different aspects of the novel have changed at a different pace. If one compares modernist novels with those of a 100 years previously, not only is an inward turn noticeable but also an outward turn: the sky, for example, is much more present. This change does not, however, coincide with the Victorian-modernist divide but rather comes when the influence of romantic poetry reaches the novel. This c