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The hypothalamus is the central regulator of energy homeostasis. Hypothalamic neuronal circuits are disrupted upon overfeeding, and play a role in the development of metabolic disorders. While mouse models have been extensively employed for understanding the mechanisms of hypothalamic dysfunction, functional magnetic resonance imaging (fMRI) on hypothalamic nuclei has been challenging. We implemen

Objective: Patient-provider relationships with primary care and need for hospitalisations are related within the complex networks comprising healthcare. Our objective was to analyse mean days hospitalised, using registration status (active or passive listing) with a provider and number of consultations as proxies of patient-provider relationships with primary care, adjusting for morbidity burden,

Popular Abstract in Swedish Digital bildteknik dominerar snart all bildhantering inom alla delar av samhället. Målsättningen med denna avhandling var att utveckla en undersökningsmetod för mätning av knäleden i belastat läge med hjälp av digital bildplatteteknik. Vad är bildplatteteknik? Traditionellt har röntgenbilder framställts med hjälp av fotografisk film. De framkallade bilderna har sedan The overall aim of this study was to develop and evaluate a measurement system for computed radiography (CR) and Picture Archiving and Communication Systems (PACS), permitting measurements of long distances and angles in and between related images. The developed measurement system, which was based on the QUESTOR Precision Radiography (QPR) system, was applied to the weight-bearing knee with specia

Long--term intensive endurance training leads to increased left ventricular mass and increased left ventricular end--diastolic and left atrial end--systolic diameters. Different types of sports tend to give rise to distinct morphological forms of the athlete's heart. However, the sport--specific aspects have not been fully investigated in female athletes. The purpose of the present study was to in

Röststörningar och halsirritation anses ofta bero på gastroesofageal refluxsjukdom (GERD). Emellertid är såväl röstsymtomen som fynden vid svalg- och larynxundersökningar oftast ospecifika hos patienter med misstänkt reflux. Dessutom baseras refluxdiagnosen hos flertalet patienter enbart på just forekorosten av röst- och halssymtom. Därfor är sambanden mellan GERD och röststörningar fortfarande in

Objectives: To develop and validate a new algorithm to identify patients with rheumatoid arthritis (RA) and estimate disease prevalence using administrative health databases (AHDs) of the Italian Lombardy region. Design: Case-control and cohort diagnostic accuracy study. Methods: In a randomly selected sample of 827 patients drawn from a tertiary rheumatology centre (training set), clinically vali

BackgroundHigh quality primary care is expected to be the basis of many health care systems. Expectations on primary care are rising as societies age and the burden of chronic disease grows. To stimulate adherence to guidelines and quality improvement, audit and feedback to professionals is often used, but the effects vary. Even with carefully designed audit and feedback practices, barriers relate

Objectives: To explore associations between carer burden and characteristics of (1) the informal carer, (2) the person with dementia, and (3) the care support network in 8 European countries. Design: Cross-sectional study. Setting: People with dementia judged at risk of admission to long-term care (LTC) facilities in 8 European countries (Estonia, Finland, France, Germany, Netherlands, Spain, Swed

Using micro-level survey data from the National Institute of EconomicResearch’s Economic Tendency Survey, we find that a relatively largeshare of Swedish households is ill-informed about the rate of inflation inthe economy, with perceived and expected rates of inflation deviatingsubstantially from official measures. Probit analysis of the data indicatesthat such inflation illiteracy is related to

Fibrosis is the result of dysregulated inflammation and tissue repair, and is characterized by the excessive accumulation of extra cellular matrix (ECM) proteins. It causes detrimental effects to the afflicted tissue and can subsequently lead to organ failure. Sterile liver inflammation and hepatic fibrosis are associated with many liver disorders of different etiologies. Both type 1 and type 2 in

Students’ learning developments of limits were studied in a calculus course. Theiractions, such as problem solving and reasoning, were considered traces of theirmental representations of concepts and were used to describe the developmentsduring a semester. Several students went through the course with a vague conception of limits which in some cases was wrong. A higher awareness about their mental

The paper presents a work in progress which is part of a larger study. Studentslearning analysis was investigated with the aim to find out how their concept images changed from the beginning of an analysis course to a year after the course. Their links between concepts were studied after the year had passed. The influence of the students’ pre-knowledge was durable and sometimes prevented students

Background: Pesticide use is increasing in low- and middle-income countries (LMICs) including Costa Rica. This increase poses health risks to farm owners, farm workers, and communities living near agricultural farms. Objective: We aimed to examine the health effects associated with occupational pesticide exposure in farm owners and workers from conventional and organic smallholder farms in Costa R