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The c-KIT receptor tyrosine kinase mediates the cellular response to stem cell factor (SCF). Whereas c-KIT activity is important for the proliferation of hematopoietic cells, melanocytes and germ cells, uncontrolled c-KIT activity contributes to the growth of diverse human tumors. Suppressor of cytokine signaling 6 (SOCS6) is a member of the SOCS family of E3 ubiquitin ligases that can interact wi

Background: Moths have evolved highly successful mating systems, relying on species-specific mixtures of sex pheromone components for long-distance mate communication. Acyl-CoA desaturases are key enzymes in the biosynthesis of these compounds and to a large extent they account for the great diversity of pheromone structures in Lepidoptera. A novel desaturase gene subfamily that displays Delta 11

We consider a moving-boundary problem associated with the fluid model for biofilm growth proposed by J. Dockery and I. Klapper, Finger formation in biofilm layers, SIAM J. Appl. Math. 62 (3) (2001) 853–869. Notions of classical, weak, and variational solutions for this problem are introduced. Classical solutions with radial symmetry are constructed, and estimates for their growth given. Using a we

The millimeter-wave phased array in the user equipment (UE) for 5G communication is studied in this letter. In particular, the body effect on the phased array in the UE at 15 GHz is investigated with the 3-D measurement data, and its impact on some key parameters for phased array in the UE, such as the total scan pattern, the coverage efficiency, and the probability of detection, are analyzed.

LevMacinstrumentet är ett analysinstrument under utveckling som utnyttjar leviterade droppar på 100 nl ? 2 ?l. Genom att använda leviterade droppar med den omgivande atmosfären som enda kontaktyta, undviker LevMac?en de vanligaste problemen associerade med miniatyrisering av analytiska tekniker, t.ex. kontaminering av provet genom desorption från provbehållaren eller andra gränsytor, adsorption av

This thesis aims at presenting the differences and similarities between the Swedish and Canadian legal system, by means of search and seizure regulations. In doing this I hope to provide the readers, whether it is a Swede or a Canadian, with a perspective on their own legal system. In the limited time and space offered for the completion of this thesis, I had to choose one specific area of law to

This paper examines the hydropolitical vulnerabilities and resiliencies in the San Juan River Basin located on the border between Nicaragua and Costa Rica. This examination is possible by studying the characteristics of vulnerable and resilient international river basins presented in a UNEP report from 2007. Further, this paper will assess the risks of escalating conflict and the possibilities of

Palliative care supports referring colleagues in multiples ways. This support to referring colleagues is not often explored in the literature, yet the psychological concept that best describes it is the holding environment. The holding environment is the relational space palliative care offers referring clinicians for processing emotions and information. Using the case of Gloria, a patient living

Introducing seaweed to new food markets entails new challenges concerning efficient preservation. Hence, this study explores high-pressure processing (HPP) as an alternative technique to conventional methods by evaluating its effects on the composition, quality, and microbial safety of the Swedish grown macroalgae Saccharina latissima. The results from the physicochemical analysis showed that afte

On 5 January 2023, the Swedish Government announced the decision to introduce new restrictions to enter Sweden: due to the spread of Covid-19 in China, travellers from this direction need to show negative Covid-test results. In cases when there is no possibility of showing the results, the travellers are not allowed to enter Sweden. Governmental Ordinance (2023:2) was temporary and lasted from 7 J

Purpose: Adolescents with congenital heart disease transition from childhood to adulthood and transfer from pediatric-oriented to adult-oriented care. High-level empirical evidence on the effectiveness of transitional care is scarce. This study investigated the empowering effect (primary outcome) of a structured person-centered transition program for adolescents with congenital heart disease and s

Background: People with inflammatory arthritis often experience challenges at work and balancing paid work and energy in everyday life. Low work ability is common, and people with inflammatory arthritis face high risks of losing their jobs and permanent exclusion from the labour market. Context-specific tailored rehabilitation targeting persons with inflammatory arthritis is limited. The aim of th

Background: Nail psoriasis (NP) is common and of high importance in patients with psoriasis. Complete resolution of NP at week 24‒26 is an unambiguous nail outcome accessible for indirect treatment comparison of biologics. Objective: To evaluate the comparative efficacy of approved biologics in achieving complete resolution of NP at week 24‒26. Methods: A network meta-analysis (NMA) was conducted

Type 2 diabetes (T2D) is characterised by defective insulin exocytosis from the pancreatic β cells, accompanied by insulin resistance. Reduced β cells mass is often seen in T2D individuals, caused by enhanced β cells apoptosis. It is now understood that several components drive β cells dysfunction and apoptosis. These are glucose-and lipo-toxicity, ER stress, pro-inflammatory cytokines, dysfunct