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Mutational signatures are patterns of mutations that arise during tumorigenesis. We present an enhanced, practical framework for mutational signature analyses. Applying these methods to 3,107 whole-genome-sequenced (WGS) primary cancers of 21 organs reveals known signatures and nine previously undescribed rearrangement signatures. We highlight interorgan variability of signatures and present a way
Tungsten (W) and niobium (Nb) belong to the refractory metal group and are used as alloying elements in steels and superalloys for high demand products. These metals are also used in a high purity single-phase state for products within nuclear, space, military and research facilities.In the current study, tool wear development and surface quality at different cutting conditions have been evaluated
An LU in-house style for English has developed over the years. To the extent possible it is desirable that communication to the outside world is as cohesive as possible and to this end the following LU style is recommended. Language varietyThe LU Language policy stipulates British English. This is the recommended variety unless special circumstances call for a deviation.Some examples:Verb endings:
As there currently are not so many known studies which directly evaluate how diversity indices have been used in different contexts, following literature study was made with the purpose of investigating how three of the most commonly used diversity indices (including Shannon-Wiener’s and Simpson’s Indices as well as a certain index measuring taxonomic diversity) are representing different categori
It is evident that Sarajevo has major challenges to create a dynamic culture around entrepreneurship. The reports also outline major constraints entrepreneurs face when hiring and retaining qualified labour. By applying the ILO’s Inclusive Entrepreneurship Ecosystem Framework, this report presentsthe root causes behind these challenges, and proposes ways forward to better include women and young p
Accountability is a central topic in administrative law. To hold persons and institutions executing public power legally accountable in various ways is linked to ideas of good governance, democracy, legitimacy, and the rule of law. In the last decades, established structures for accountability in the public sector have been challenged through processes of privatization of public services, digitali
This paper assesses the opportunities for resource- and energy-efficient biojet fuel production from forest-based biomass utilising existing industrial infrastructure in Sweden. Two categories of production pathways are considered: one including technologies that are certified for the production of biojet fuel, and the other uncertified technologies under development. Aspects included are producti
This book is the first to address the important interrelationship between second homes and climate change, which has become an increasingly relevant issue for many regions around the world. Second homes are often a key source of tourist visitation as well as economic benefit for their host communities. The chapters provide an array of international case studies and climate change impacts, includin
In this article, we investigate public support for eco-social policies combining goals of social justice and ecological sustainability. Eco-social policies contribute both to providing a social floor or redistributing resources to where they are needed and to respecting an ecological ceiling by keeping human activities within ecological limits. We discuss five such policies and highlight arguments
The medical imaging technique called “ultrasound optical tomography” (UOT) entails light scattered in tissue that is given spatial information by interacting with an ultrasound field, thus allowing for molecular information to be imaged with ultrasonic resolution. This thesis discusses how UOT can be implemented, with most attention put toward the implementation using spectral-hole-burning filters
Morphology and facet engineering have been proved efficient strategies to prepare high-performance photoelectrochemical (PEC) materials. WO3/BiVO4 heterojunction photoanodes with different morphologies were prepared by simply controlling the amount of electrodeposited charge. The coral-like WO3/BiVO4 photoanode with the orientation growth of {110} and {011} active facets of BiVO4 exhibited the opt
The Astropy Project supports and fosters the development of open-source and openly developed Python packages that provide commonly needed functionality to the astronomical community. A key element of the Astropy Project is the core package astropy, which serves as the foundation for more specialized projects and packages. In this article, we summarize key features in the core package as of the rec
We report the synthesis of various binary and ternary inorganic and hybrid organic-inorganic iodide nanocrystals (NCs) starting from molecular iodine (I2). The synthesis described herein utilizes a reaction between I2 and oleylamine, which results in oleylammonium iodide, an iodide precursor that can be directly used in the preparation of iodide-based NCs. The generality of the synthesis was demon
In this work, we proposed to include remote sensing techniques as a part of the methodology for natural lake bottom mapping, with a focus on the littoral zone. Due to the inaccessibility of this zone caused by dense vegetation, measurements of the lake bottom and the coastline are also difficult to perform using traditional methods. The authors of this paper present, discuss and verify the applica
Two conspicuous wet shifts in the peat stratigraphy of Store Mosse in southern Sweden, associated with bog-wide changes in vegetation and degree of peat decomposition, were analysed at high resolution. The bog-surface wetness (BSW) proxy data (organic matter bulk density, C/N ratio, plant macrofossils and testate amoebae) highlight the importance of interactions between vegetation composition, mic
Urban areas provide breeding habitats for many species. However, animals raised in urban environments face challenges such as altered food availability and quality, pollution and pathogen assemblages. These challenges can affect physiological processes such as immune function and antioxidant defences which are important for fitness. Here, we explore how levels of urbanisation influence innate immu
The agriculture sector can contribute to climate change mitigation by reducing its own greenhouse gas (GHG) emissions, sequestering carbon in vegetation and soils, and providing biomass to substitute for fossil fuels and other GHG-intensive products. The sector also needs to address water, soil, and biodiversity impacts caused by historic and current practices. Emerging EU policies create incentiv
After World War II and prior to the financial deregulation of the 1980s,monetary policy in Sweden as well as in other western Europeancountries rested chiefly on a system of far-reaching non-market-orientedcontrols of credit flows and interest rates. How was monetary policyconducted in such an environment of financial repression, where thecentral bank was unable to rely on traditional monetary pol
