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Interactions between danger and pathogen-associated molecular patterns (DAMP and PAMP) and pattern recognition receptors such as Toll-like receptors (TLRs) are critical for the regulation of the inflammatory process via activation of NFκB and cytokine secretion. In this report, we investigated the capacity of LPS-free S100A9 (DAMP) protein to activate human and mouse cells compared to lipoprotein-
Virtual Network Operators lease bandwidth from different data carriers to offer well managed Virtual Private Networks. By using proprietary algorithms and leased resource diversity they can offer Quality of Service, at competitive prices, which is difficult to attain from traditional data network operators. Since maximizing the profit is a key objective for virtual network operators, in this paper
BackgroundWe aimed to evaluate if optimization by maximizing QRS duration (QRSd) reduction is feasible in an all-comer cardiac resynchronization therapy (CRT) population, and if reduced, QRSd is associated with a better clinical outcome.MethodsPatients with LBBB receiving CRT implants during the period 2015–2020 were retrospectively evaluated. Implants from 2015–2017 were designated as controls. S
Despite of the ambitious aim of the ATAD, the adverse effect of double taxation caused by the implementation of it is unsolved. It is therefore up to taxpayers to solve the conflict of norms by identifying the correct source of law for eliminating double taxation. The thesis focuses on the double taxation caused by the implementation of ATAD and identifying the correct source of law, if possible,
Objectives: In this thesis we studied the performance of active extension portfolios constructed by using momentum/contrarian strategies. Fundamentally, the difference between the 130/30 and the long-only asset classes is the relaxation from the long-only constraint. The main implication of this study is to find out whether the 130/30 strategy is value adding, in comparison to other actively manag
Purpose: To explore the roles of brand culture, brand image and brand vision in the context of “green” corporate brands, and identify pitfalls when these elements are not aligned. Methodology: Qualitative research method using primary data (interviews with former and current employees) and secondary data. Findings: In this paper, there are several findings derived from an employee perspective and
This study analysed demand for 12 metals in global climate mitigation scenarios up to 2060 and quantified the impacts on demand of different assumptions on improvements and technological mix. Annual and cumulative demands were compared with reserves and current mining rates. The study results showed that reserves are sufficient to support the total level of solar power, wind power and electric mot
Occasional fog is a critical water source utilised by plants and animals in the Namib Desert. Fog basking beetles (Onymacris unguicularis, Tenebrionidae) and Namib dune bushman grass (Stipagrostris sabulicola, Poaceae) collect water directly from the fog. While the beetles position themselves optimally for fog water collection on dune ridges, the grass occurs predominantly at the dune base where l
BACKGROUND: Cholecystokinin (CCK) has been suggested to be involved in the development and course of acute pancreatitis. In the present study we measured plasma CCK concentrations in acute experimental pancreatitis (AEP) in the rat, and evaluated the role of circulating CCK levels on the initial pancreatic damage in pancreatitis. METHODS: Endogenous hyperCCKemia was induced by surgical biliodigest
Plants sense and integrate a variety of signals from the environment through different interacting signal transduction pathways that involve hormones and signaling molecules. Using ALTERNATIVE OXIDASE1a (AOX1a) gene expression as a model system of retrograde or stress signaling between mitochondria and the nucleus, MYB DOMAIN PROTEIN29 (MYB29) was identified as a negative regulator (regulator of a
The geometry of several realistic models of the metal coordination sphere in the blue copper proteins has been optimised using high-level quantum chemical methods. The results show that the optimal vacuum structure of the Cu(II) models is virtually identical to the crystal structure of oxidised blue copper proteins. For the reduced forms, the optimised structure seems to be more tetrahedral than t
Happiness is an affect. Affects are thought to be part of our subjective experiences. In the past, human beings have constructed complex relationships with happiness outside of ourselves. Since sociocultural values laden to happiness established various linkages with objects, happiness seemed to become materialised and accessible, which is expressed, for example, as the UN’s World Happiness Report
