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The aggregation of proteins into amyloid fibrils via erroneous folding, also known as misfolding, occurs in several diseases. As a consequence, the study of the kinetics and thermodynamics of this process is currently intensely pursued. Here, we study a minimalistic lattice-based model for amyloid formation using Monte Carlo techniques to sample the grand canonical ensemble, where the chemical pot
Thesis purpose: The purpose of this study is to gain knowledge about baby boomers’ motivations for using either digital or analogue touchpoints in the high involvement customer journey. This ultimately contributes to an increased understanding of the high involvement customer journey. Methodology: A qualitative study with social constructionism as the research philosophy, where an abductive appro
Styvhetsförändringar i bröstvävnad är ofta kopplade till en patologisk förändring. Vissa cancertyper som infiltererande duktalt carcinom kan vara åtta gånger så styv som fettvävnaden runt omkring. Genom att komprimera bröstet och mäta trycket på bröstets yta har man identifierat att det blir en lokal förhöjning i tryck där det finns en tumör. Med hjälp av den här typen av mekanisk avbildning av brA change in stiffness of breast tissue is often connected to a pathological change. Some types of breast cancer such as infiltrating ductal carcinoma can be up to eight times stiffer than fat tissue. It has been found that during compression of the breast there will be a local area of relatively high stress at the breast surface at the location of a tumour. This type of mechanical imaging of the b
Background: Blockchain technology has during the last years become a hot topic for supply chain management. Solutions are being developed and sold, but exactly what blockchain technology can bring to the supply chain is unclear. The technology can be divided into two main varieties, public and private. The public version sparked the initial interest in the technology but has not been as heavily pr
Cross-functional teams and meetings are recurrent structuring tools in contemporary knowledge organisations. They are recommended as solutions to enhance innovation and creativity. Current research gathers a myriad of reference to the benefits of such tools, but studies of their potential negative effects remain limited. This paper is specifically concerned with the effect of interdisciplinary tea
The many-body problem in quantum mechanics always presents new challenges and ways to discover new properties of existing materials. The difficulty (if not the impossibility) to solve the many-body problem analytically makes the numerical methods an appealing approach. Here we consider a Python code, which is under development to become an open-source tool to perform studies of finite lattice syst
Digitalisering är utan tvekan 2000-talets viktigaste bidragande orsak till utvecklingen av den globala ekonomin. Skatteplanering och skatteflykt bland multinationella bolag urholkar nationers skattebas som finansierar det offentliga välfärdssystemet såsom sjukvård, utbildningsinstitutioner och infrastruktur. Digitala affärsmodeller genererar intäkter annorlunda än traditionella affärsmodeller ocDuring the 21th century, digitalization is considered the most important development of the modern global economy. Tax avoidance is a growing issue for governments globally, that are loosing lots of tax money to finance public welfare systems supporting healthcare, educational institutions and infrastructures. Value creation in digital business models generates profits different than traditional b
In the field of computational biology, fluorescence microscopy images often constitute the input source of information. The process of binarization of raw images to delineate interesting objects requires image segmentation into signal and background pixels. Several methods to perform image segmentation exist, the Otsu method being a popular unsupervised example. The Otsu method's lack of pro
Globalization has led to the emergence of global value chains (GVCs) and most of the world’s trade is now in intermediate inputs. This has raised questions about employment in GVCs and attracted the interest of researchers and policymakers alike, but is difficult to study empirically. This paper investigates job creation in simple and complex GVCs for 43 economies between 2000 and 2014 on the basi
The DARPA Grand Challenge (DGC) 2005 was a competition, in form of a desert race for autonomous ground vehicles, arranged by the U.S. Defense Advanced Research Project Agency (DARPA). The purpose was to encourage research and development of related technology. The objective of the race was to track a distance of 131.6 miles in less than 10 hours without any human interaction. Only public GPS signa
The Danish religious landscape has been significantly transformed, especially during the last three decades. This transformation is marked by the shift from near religious hegemony towards a much more diverse religious population. Originally, the Danish Lutheran state church was closely intertwined with the governmental administration of the country after the reformation in Denmark of 1536 and the
Purpose: We investigated how the C flow from plants to microorganisms varies throughout the year in a temperate grassland. Additionally, we investigated how the C flow relates to saprotrophic activity and vegetation changes. Methods: In situ stable isotope pulse labelling (13CO2) was employed to estimate the flow of recently plant-derived C to soil microorganisms by using signature fatty acids. Ba
Tungsten (W) and niobium (Nb) belong to the refractory metal group and are used as alloying elements in steels and superalloys for high demand products. These metals are also used in a high purity single-phase state for products within nuclear, space, military and research facilities.In the current study, tool wear development and surface quality at different cutting conditions have been evaluated
The minimization of a functional consisting of a combined L 1/L 2-data-fidelity term and a total variation term, named L 1-L 2-TV model, is considered to remove a mixture of Gaussian and impulse noise in images, which are possibly additionally deformed by some convolution operator. We investigate analytically the stability of this model with respect to its parameters and link it to a constrained m
This paper assesses water quality that is used for vegetable irrigation in Tamale Metropolis, Ghana. A mixed-method of research design was employed in this study to collect and analyze the data based on survey instruments. The paper found that Escherichia coli (E. coli) that is usually used as an indicator of water contamination and heavy metals exist in all taken water samples. The mean concentra
Every of the seven chapters of the course aims at introducing the students to the basics of Romanian language in the larger context of the Romanian culture and civilization development, with the ultimate purpose of settling both a few essential theoretical knowledge and some practical communication skills for the foreign students as inhabitants of Romania. The compulsory tasks at the end of each c
We welcome Raymond et al.’s invitation to further discuss the ‘pragmatics’ of relational thinking in sustainability science. We clarify that relational approaches provide distinct theoretical and methodological resources that may be adopted on their own, or used to enrich other approaches, including systems research. We situate Raymond et al.’s characterization of relational thinking in a broader
Adaptive and flexible approaches based on implementing different measures as new information emerges have been proposed as a way of enabling robustness towards uncertain future climate change. However, the success of flexible approaches in practice depends on the stability of the relevant organizational landscapes. In this paper, we draw upon key insights from the institutional theories of organiz
The human-driven loss of biodiversity has numerous ecological, social, and economic impacts at the local and global levels, threatening important ecological functions and jeopardizing human well-being. In this perspective, we present an overview of how tropical defaunation—defined as the disappearance of fauna as a result of anthropogenic drivers such as hunting and habitat alteration in tropical
