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BACKGROUND: α-synuclein (α-syn) aggregation contributes to the progression of multiple neurodegenerative diseases. We recently found that the isoform b of the co-chaperone DNAJB6 is a strong suppressor of a-syn aggregation in vivo and in vitro. However, nothing is known about the role of the endogenous isoform b of DNAJB6 (DNAJB6b) in health and disease, due to lack of specific antibodies.OBJECTIV
Coherence Reliability
The aim of the study was to highlight the experiences and expectations of Swedish parents with respect to general parental education within child healthcare. Interviews were carried out with 25 parents who had attended education sessions. With a few exceptions the fathers did not take part, and those mothers who did comprised a relatively highly educated group; their views therefore predominate in
All stars are formed in some form of cluster or association. These environments can have a much higher number density of stars than the field of the galaxy. Such crowded places are hostile environments: a large fraction of initially single stars will undergo close encounters with other stars or exchange into binaries. We describe how such close encounters and exchange encounters will affect the pr
In this paper, we engage with the question of the normative content of the resilience concept. The issues are approached in two consecutive steps. First, we proceed from a narrow construal of the resilience concept – as the ability of a system to absorb a disturbance – and show that under an analysis of normative concepts as evaluative concepts resilience comes out as descriptive. In the second pa
The problem addressed in this paper is a case of word order microvariation in Mainland Scandinavian: optional vs. obligatory Object Shift (OS). Following standard assumptions (see Selkirk 1996), weak object pronouns are assumed to be affixal clitics at PF which do not themselves have the status of prosodic words. Since adverbs (including negation), areunsuitable as hosts, weak object pronouns may
Decisions about disaster preparedness are rarely informed by cost-benefit analyses. This paper presents an economic model to address the thorny question, 'how prepared is prepared enough?' Difficulties related to the use of cost-benefit analysis in the field of disaster management concern the tension between the large number of high-probability events that can be handled by a single emergency resp
