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We have developed an integrative analysis method combining genetic interactions, identified using type l diabetes genome scan data, and a high-confidence human protein interaction network. Resulting networks were ranked by the significance of the enrichment of proteins from interacting regions. We identified a number of new protein network modules and novel candidate genes/ proteins for type 1 dia
A number of studies have analysed how multinational enterprises (MNEs) develop appropriate strategies for managing the institutionally different contexts of various markets. However, we still know rather little about how MNEs manage different institutional pressures when they operate in emerging markets. These markets have a higher level of uncertainty as their values and structures undergo change
In this article, the often conflictual intersection between transnational dimensions of religious social formations and narratives of global governance and national security is interrogated. Concretely, the article examines how the relation, between the transnational activities and commonalities actuated by the Islamic revivalist movement Tablighi Jama’at and the perception that it hosts and nouri
Popular Abstract in Swedish Tillväxthormon (GH) insöndras stötvis från hypofysen. Insöndringen är som högst nattetid, och de högsta nivåerna ses under puberteten för att därefter avta succecivt med ökande ålder. En av de vanligaste orsakerna till brist på GH är godartade tumörer i hypofys och hypofysnära områden där även behandling med kirurgi och strålbehandling kan bidra till hypofysinsufficiensIn childhood onset growth hormone deficiency (GHD) a reduction in cardiac left ventricular mass (LVMi) and impairment of cardiac systolic function, as well as in glomerular filtration rate (GFR) has been shown. In study I, we showed that a low dose of GH treatment for 10 months resulted in increased LVMi and kidney size. No significant improvement in cardiac systolic function or GFR, except for a
Popular Abstract in Swedish Förekomsten av fetma ökar lavinartat över hela världen, Sverige inte undantaget, och detta är en stor bidragande orsak till att antalet fall av typ 2 diabetes tilltar på ett liknande sätt. Både fetma och typ 2 diabetes är sjukdomar med ett komplicerat mönster av samverkande genetiska och miljömässiga faktorer. Drabbade individer har en klart ökad risk att drabbas av hjäThe worldwide prevalence of obesity and type 2 diabetes is increasing rapidly. Both disorders depend on genetic and environmental factors. The studies included in this thesis investigated the possible association of the FOXC2 and CAPN10 genes with obesity, insulin resistance, type 2 diabetes, and related phenotypes. FOXC2 encodes a forkhead transcription factor, which was identified as a key regul
Background/Aims: Two differently charged polypeptides, poly-L-lysine (PL) and poly-L-glutamate (PG), have previously been shown to reduce postoperative intra-abdominal adhesions. This study aims to investigate the possible toxic effects and to establish a lowest effective antiadhesive dose. Methods: 152 mice were investigated with a well-known adhesion model and given different concentrations of t
Recent debate and associated initiatives dealing with public sector innovation have mainly aimed at improving the effectiveness and efficiency of the delivery of public services and improved transparency and user friendliness. Beyond typical administrative reforms, innovation is expected to help address societal challenges such as the aging population, inclusion, health care, education, public saf
Neutron radiation produces high-energy gamma radiation through (n,gamma) reactions in matter. This can be used to detect neutron sources indirectly using gamma spectrometers. The sensitivity of a gamma spectrometer to neutrons can be amplified by surrounding it with polyvinyl chloride (PVC). The hydrogen in the PVC acts as a moderator and the chlorine emits prompt gammas when a neutron is captured
Fetal cell replacement therapy or in utero hematopoietic cell transplantation (IUHCT) is proposed as a non-myeloablative alternative to bone marrow transplantation (BMT) for a number of inborn immunologic, hematologic and metabolic disorders. IUHCT represents the method through which variable amounts of natural or genetically modified hematopoietic cells can be transferred to the fetal recipient i
OBJECTIVE-Hemoglobin A(1c) (A1C) has emerged as a recommended diagnostic tool for identifying diabetes and subjects at risk for the disease. This recommendation is based on data in adults showing the relationship between A1C with future development of diabetes and microvascular complications. However, studies in the pediatric population are lacking. RESEARCH DESIGN AND METHODS-We studied a multiet
In order to allow different software applications, in constant evolution, to interact and exchange data, flexible file formats are needed. A file format specification for different types of content has been elaborated to allow communication of data for the software developed within the European Network of Excellence "NANOQUANTA", focusing on first-principles calculations of materials and nanosyste
This thesis discusses two cases of rape against adolescent girls that happened in Cianjur, West Java, and Lombok, West Nusa Tenggara in Indonesia. First of all, the thesis evaluates the availability of the legal framework in the area of rape in Indonesia that ensures the victims rights with regard to rape. It will look at whether Indonesia has ratified relevant international human rights instrumen
Ben Ali’s authoritarian rule over Tunisia was caused by corruption, nepotism, and unemployment. I aim to show that the downfall of the regime was enhanced by the repression of freedom of expression. Limiting access to information creates struggle for people in their daily lives; they become more dissatisfied and the will to create change becomes stronger. Repressing freedom of expression to hide t
As a lecturer in mathematics for first-year university students one faces several challenging problems; big classes, low motivation and a high level of abstraction. Based on interviews with several experienced university lecturers in mathematics, we present a toolbox of tips and tricks intended to be used when reflecting over one's own teaching in order to improve it.
This article examines the foundation of β-cell failure in type 2 diabetes (T2D) and suggests areas for future research on the underlying mechanisms that may lead to improved prevention and treatment.RESEARCH DESIGN AND METHODS: A group of experts participated in a conference on 14-16 October 2013 cosponsored by the Endocrine Society and the American Diabetes Association. A writing group prepared t
This study evaluated a technique to allow the long-term monitoring of individual fishes of known sex in the wild using sex confirmation in close proximity to the reproductive period combined with individual tagging. Hundreds of partially migratory roach Rutilus rutilus were tagged with passive integrated transponders (PIT) following sex determination in spring and various performance measures were
Objective. To follow patients with fibromyalgia six and 24 months after they finished a six-month treatment programme. The programme comprised pool exercise therapy, adjusted to the patients' limitations, and education based on their health problems. Methods. Twenty-six patients were examined six and 24 months after the completion of the treatment programme with the Fibromyalgia Impact Questionnai
