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An annotated high-content fluorescence microscopy dataset with Hoechst 33342-stained nuclei and manually labelled outlines

Automated detection of cell nuclei in fluorescence microscopy images is a key task in bioimage analysis. It is essential for most types of microscopy-based high-throughput drug and genomic screening and is often required in smaller scale experiments as well. To develop and evaluate algorithms and neural networks that perform instance or semantic segmentation for detecting nuclei, high quality anno

B-type natriuretic peptide for prediction of incident clinically significant abdominal aortic aneurysm : A population-based prospective study

Pathogenesis of abdominal aortic aneurysm (AAA) is unclear. The aim of this study was to evaluate inflammatory and hemodynamic plasma biomarkers as predictors for AAA in the prospective longitudinal cohort of middle-aged individuals from the cardiovascular cohort of the Malmö Diet and Cancer Study ( n=5551; 1991-94). C-reactive protein, cystatin C, copeptin, N-terminal pro-B-type natriuretic pepti

Deep learning algorithm performs similarly to radiologists in the assessment of prostate volume on MRI

ObjectivesProstate volume (PV) in combination with prostate specific antigen (PSA) yields PSA density which is an increasingly important biomarker. Calculating PV from MRI is a time-consuming, radiologist-dependent task. The aim of this study was to assess whether a deep learning algorithm can replace PI-RADS 2.1 based ellipsoid formula (EF) for calculating PV.MethodsEight different measures of PV

Validation of cause of death classification after heart transplantation and cause-specific life expectancy compared to the general population

Background: Post heart-transplant survival has increased, but information is lacking on specific causes of death and life expectancy. We aimed to assess cause-specific loss of life-years compared to the general population, evaluate classification for cause of death after heart transplantation, and assess validity of cause of death data from the International Society of Heart and Lung Transplant (I

Bioactive adrenomedullin for assessment of venous congestion in heart failure

Aims: Bioactive adrenomedullin (bio-ADM) is a vascular-derived peptide hormone that has emerged as a promising biomarker for assessment of congestion in decompensated heart failure (HF). We aimed to evaluate diagnostic and prognostic performance of bio-ADM for HF in comparison to amino-terminal pro-B-type natriuretic peptide (NT-proBNP), with decision thresholds derived from invasive haemodynamic

Pathogen-driven degradation of endogenous and therapeutic antibodies during streptococcal infections

Group A streptococcus (GAS) is a major bacterial pathogen responsible for both local and systemic infections in humans. The molecular mechanisms that contribute to disease heterogeneity remain poorly understood. Here we show that the transition from a local to a systemic GAS infection is paralleled by pathogen-driven alterations in IgG homeostasis. Using animal models and a combination of sensitiv

Bimolecular Reaction Mechanism in the Amido Complex-Based Atomic Layer Deposition of HfO2

The surface chemistry of the initial growth during the first or first few precursor cycles in atomic layer deposition is decisive for how the growth proceeds later on and thus for the quality of the thin films grown. Yet, although general schemes of the surface chemistry of atomic layer deposition have been developed for many processes and precursors, in many cases, knowledge of this surface chemi

Role of serotype and virulence determinants of Streptococcus pyogenes biofilm bacteria in internalization and persistence in epithelial cells in vitro.

Streptococcus pyogenes causes a multitude of local and systemic infections, the most common being pharyngitis in children. Recurrent pharyngeal infections are common and are thought to be due to the re-emergence of intracellular GAS upon completion of antibiotic treatment. The role of colonizing biofilm bacteria in this process is not fully clear. Here, live respiratory epithelial cells were inoc

MAC-1 marks a quiescent and functionally superior HSC subset during regeneration

Mouse hematopoietic stem cells (HSCs) have been extensively defined both molecularly and functionally at steady state, while regenerative stress induces immunophenotypical changes that limit high purity isolation and analysis. It is therefore important to identify markers that specifically label activated HSCs to gain further knowledge about their molecular and functional properties. Here, we asse

3d Finite Element Models Reconstructed From 2d Dxa Images Improve Hip Fracture Prediction Compared to Areal Bmd in Mros Sweden Cohort

Bone strength is an important contributor to fracture risk. Areal bone mineral density (aBMD) derived from dual-energy X-ray absorptiometry (DXA) is used as a surrogate for bone strength in fracture risk prediction tools. 3D finite element (FE) models predict bone strength better than aBMD, but their clinical use is limited by the need for 3D computed tomography and lack of automation. We have ear

Impact of bridging with left ventricular assist device on right ventricular function following heart transplantation

AIMS: Patients awaiting orthotopic heart transplantation (OHT) can be bridged utilizing a left ventricular assist device (LVAD) that reduces left ventricular filling pressures, decreases pulmonary artery wedge pressure, and maintains adequate cardiac output. This study set out to examine the poorly investigated area of if and how pre-treatment with LVAD impacts right ventricular (RV) function foll

Development of Perovskite Nanocrystal Superlattices for Studies of Collective Phenomena

Colloidal perovskite nanocrystals are building blocks for novel materials due to the property of nanocrystals to self-assemble into ordered structures (superlattices). Exemplified by a prototypical perovskite CsPbBr3, research into perovskite nanocrystal superlattices is motivated by reports of intriguing phenomena such as superfluorescence and superradiance.[1] Such cooperative luminescence arise

Spatially Resolved Local Electronic Properties of 2D Lead Halide Perovskite Single Crystals Studied by X-Ray Photoemission Electron Microscopy

Recently, research on the edge states of 2D lead halide perovskites (LHPs) has been attracting much attention. The lower-energy edge state (LES) is believed to provide an efficient pathway for the dissociation of photoexcited excitons. However, the mechanism of the LES formation remains controversial, and studies that establish precisely the local electronic properties are lacking. Herein, the fir

Neurodevelopmental Outcomes 12 Years After Extremely Preterm Birth in Sweden

OBJECTIVES: We assessed the prevalence of neurodevelopmental disabilities (NDDs; cognition, cerebral palsy, vision/hearing, epilepsy), attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), developmental coordination disorder (DCD), behavior problems, and multimorbidity in a national cohort of children born extremely preterm (EPT, <27-week gestation) to provide a comprehe

Mven11 schema 20150112

SCHEMA 20110322 PRELIMINÄRT SCHEMA 20150112 Schema för MVEN11 metodik och praktik, 15 hp vt 15 Kurstid: 19 januari – 20 mars 2015 Kursansvarig: Högni Hansson 0721-555648, hogni.hansson@cec.lu.se Introduktion: måndagen den 19 januari 2015, Ekologihuset M (Maskrosen), kl. 10.15-12.00 Lärare: HH Högni Hansson hogni.hansson@cec.lu.se KF Kennet Falk kennet.falk@tekis.se AW Anna Wallin anna.wallin@infos

https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/mven11_schema_20150112.doc - 2026-06-04

Åtgärder med anledning av rekommendationer från utredning om terminstider vid Lunds universitet I 20

Brevmall Postadress Box 117, 221 00 Lund Besöksadress Paradisgatan 5 B Telefon föredragande 046-222 70 58, vx 046-222 00 00 Fax 046-222 4715 E-post daniel.huledal@stu.lu.se Rektor Åtgärder med anledning av rekommendationer från utredning om terminstider vid Lunds Universitet Bakgrund Rektor gav den 2 april 2009 ett uppdrag till Ida Andersson att genomföra en utredning om terminstider vid LU (Dnr L

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/terminstider-atgarder-utredning.pdf - 2026-06-04