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BACKGROUND: Transforming growth factor-β1 (TGF-β1) is a potent regulator of cell growth and differentiation. TGF-β1 has been shown to be a key player in tissue remodeling processes in a number of disease states by inducing expression of extracellular matrix proteins. In this study a quantitative proteomic analysis was undertaken to investigate if TGF-β1 contributes to tissue remodeling by mediatin
When the Langerhans cells (LC) are prepared forelectron microscopy with an osmotically balanced prefixative,they display their classical criteria, but in additionthey are provided with numerous microvilli and containpinocytotic vesicles. In cross-sections the specific discshapedgranules are visualized as rod-like profiles limited bya trilaminar membrane similar to the cell membrane. Inface-on proj
We report on the study of fast-neutron background for the BIFROST spectrometer at ESS. We investigate the effect of background radiation induced by the interaction of fast neutrons from the source with the material of the neutron guide and devise a reasonable fast, thermal/cold neutron shielding solution for the current guide geometry using McStas and MCNPX. We investigate the effectiveness of the
Reduction of trans-[Pt(CN)(4)Cl-2](2-) by [Pt(NH3)(4)](2+) and [Pt(en)(2)](2+) was studied at 25 degrees C in the range 0 less than or equal to [Cl-] less than or equal to 0.4 M by use of stopped-flow spectrophotometry. The stoichiometry [Pt(IV)]:[Pt(II)] is 1:1. Rapid-scan spectra show clear-cut isosbestic points, indicating that no reaction intermediates are accumulated to a significant amount.
The ultrafiltration (UF) with diafiltration is the state-of-the-art process in the bulk pharmaceutical industry to separate solutions containing high and low molecular weight solutes. By applying UF with diafiltration, a feed stream can be separated into a concentrate with a high concentration of high molecular weight solutes and a permeate, which is nearly 100% free of high molecular weight solut
The income velocity of money in several countries such as Sweden, the United States and Great Britain, displays a U-shaped pattern for the last one hundred years. This paper proposes an explanation of this secular behavior based on an extension of Wicksell’s work on velocity emphasizing the influence of institutional changes. The secular fall in velocity in the last half of the 19th century and th
Molecular imprinting is the technology of creating artificial recognition sites in polymeric matrices which are complementary to the template in their size, shape and spatial arrangement of the functional groups. Molecularly imprinted polymers (MIPs) and their incorporation with various transducer platforms are among the most promising approaches for detection of several analytes. There are a vari
A Quality Scorecard (QSC) performance measurement model is proposed to evaluate the quality aspects of an organization in Industry 4.0. To design a QSC for the ‘Fourth Industrial Revolution’, we examined existing measures regarding costs of quality items. The measurement system was refined by simplifying duplicate measures and incorporating quality elements considered in recent international stand
Species from the genus Phytophthora are well represented among organisms causing serious diseases on trees. Phytophthora plurivora has been implicated in long-term decline of woodland trees across Europe. Here we present a draft genome sequence of P. plurivora, originally isolated from diseased European beech (Fagus sylvatica) in Malmö, Sweden. When compared with other sequenced Phytophthora speci
In this study, the use of cubosomes for topical delivery of the antimicrobial peptide (AMP) LL-37 was investigated. Topical delivery of AMPs is of great interest for treatment of skin infections caused by bacteria, such as Staphylococcus aureus. AMP containing cubosomes were produced by three different preparation protocols and compared: (i) pre-loading, where LL-37 was incorporated into a liquid
Objectives: Gallstone disease (cholelithiasis) has a familial component, but detailed data on the modification of familial risk are lacking. Using nationwide hospital and population records, we aimed to determine detailed familial risks for medically diagnosed gallstone disease.Design: Subjects were obtained from the Multigeneration Register, which contains family data on the Swedish population, a
Traditionally, international humanitarian organisations have used on-demand dispatch of disaster relief goods from regional logistics units (RLUs) for sudden onset disaster response. This paper investigates the improvements in efficiency and resilience of disaster relief operations by combining the existing method of onshore prepositioning of relief items in RLUs with offshore prepositioning of re
The PANDA (anti-Proton ANnihiliation at DArmstadt) experiment will be one of the four flagship experiments at the new international accelerator complex FAIR (Facility for Antiproton and Ion Research) in Darmstadt, Germany. PANDA will address fundamental questions of hadron physics and quantum chromodynamics using high-intensity cooled antiproton beams with momenta between 1.5 and 15 GeV/c and a de
The minimum edge dominating set (MEDS) is one of the fundamental covering problems in graph theory, which finds many practical applications in diverse domains. In this paper, we propose a meta-heuristic approach based on genetic algorithm and local search to solve the MEDS problem. Therefore, the proposed method is considered as a memetic search algorithm which is called Memetic Algorithm for mini
The distributions of migratory species in the ocean span local, national and international jurisdictions. Across these ecologically interconnected regions, migratory marine species interact with anthropogenic stressors throughout their lives. Migratory connectivity, the geographical linking of individuals and populations throughout their migratory cycles, influences how spatial and temporal dynami
