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For at least a decade, no new drug principles have been added to the therapeutic armamentarium for the treatment of lower urinary tract symptoms (LUTS) associated with or suggestive of benign prostatic hyperplasia (BPH). Theoretically, there seem to be several possibilities to improve the current treatment, which is based mainly on alpha1-adrenoceptor (AR) antagonists, 5alpha-reductase inhibitors

The minimum edge dominating set (MEDS) is one of the fundamental covering problems in graph theory, which finds many practical applications in diverse domains. In this paper, we propose a meta-heuristic approach based on genetic algorithm and local search to solve the MEDS problem. Therefore, the proposed method is considered as a memetic search algorithm which is called Memetic Algorithm for mini

The distributions of migratory species in the ocean span local, national and international jurisdictions. Across these ecologically interconnected regions, migratory marine species interact with anthropogenic stressors throughout their lives. Migratory connectivity, the geographical linking of individuals and populations throughout their migratory cycles, influences how spatial and temporal dynami

The Genographic Project is an international effort aimed at charting human migratory history. The project is nonprofit and nonmedical, and, through its Legacy Fund, supports locally led efforts to preserve indigenous and traditional cultures. Although the first phase of the project was focused on uniparentally inherited markers on the Y-chromosome and mitochondrial DNA (mtDNA), the current phase f

Marine macroalgal (seaweed) polysaccharides are highly promising for next-generation applications in several industries. However, despite the reported comprehensive potential of these polysaccharides, commercial products are scarce on the market. Seaweed cultivations are increasing in number and production quantity, owing to an elevated global trend of utilization interest in seaweed. The extracti

Cell-replacement therapies have long been an attractive prospect for treating Parkinson disease. However, the outcomes of fetal tissue-derived cell transplants in individuals with Parkinson disease have been variable, in part owing to the limitations of fetal tissue as a cell source, relating to its availability and the lack of possibility for standardization and to variation in methods. Advances

The management of non-muscle-invasive bladder cancer (NMIBC) has evolved from the first reports on bladder endoscopy and transurethral resection to the introduction of adjuvant intravesical treatment. However, disease recurrence and progression remain an ongoing risk, placing a heavy burden on healthcare resources and on patients’ quality of life. Deeper understanding of the molecular basis of the

Desert vernacular architecture is a product of a sustainable building cycle. Desert local inhabitants inherited the traditional way of building from their ancestors developed and then transferred knowledge from one generation to another. This building and cultural cycle is about to disappear in many desert vernacular settlements of the world. Global ambitions and socio-economic developments are so

Objective: To propose draft classification criteria for early stage osteoarthritis (OA) of the knee for use in a primary care setting. Methods: A group of basic scientists, physician-scientists, rheumatologists, orthopedic surgeons, and physiotherapists in a workshop setting discussed potential classification criteria for early osteoarthritis of the knee. The workshop was divided into sessions aro

While pure deliberation has still not been found online, the field of online deliberation research is blossoming. Born out of the “frustrations and possibilities” of the 1990s, a current theme in the field is to re-link deliberative theory with empirical political science. The aim of this systematic literature review is to sort out and examine important features of this development; to identify an

Ozone was applied to return activated sludge in full-scale to study how ozone impacts filamentous bacteria viability (Live/Dead®). Additionally, the ozonated sludges were subjected to anaerobic digestion trials and analysis of micropollutants. Ozone treatment (3-4.8 g O3/kg TSS) improved the settling properties of the sludge by lowering the diluted sludge volume with 7-35%. Ozone inactivated filam