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β-Mannan is abundant in the human diet and in hemicellulose derived from softwood. Linear or galactose-substituted β-mannan-oligosaccharides (MOS/GMOSs) derived from β-mannan are considered emerging prebiotics that could stimulate health-associated gut microbiota. However, the underlying mechanisms are not yet resolved. Therefore, this study investigated the cross-feeding and metabolic interaction
Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the benefits and harms, including pain, discomfort, and success rate, of any pharmacological intervention during lumbar puncture in newborn infants, compared to placebo, no intervention, non-pharmacological interventions, or other pharmacological interventions.
The magnetic Laplacian on a planar domain under a strong constant magnetic field has eigenvalues close to the Landau levels. We study the case when the domain is a disc and the spectrum consists of branches of eigenvalues of one dimensional operators. Under Neumann boundary condition and strong magnetic field, we derive asymptotics of the eigenvalues with accurate estimates of exponentially small
One of the main challenges as the market for fully commercial electrified vehicles quickly expands is predicting the electromagnetic interference (EMI) in traction voltage systems (TVSs) in differential mode (DM) and common mode (CM). The number of subsystems connected to vehicle TVSs is increasing, and thus, so are the electromagnetic compatibility (EMC) requirements. These requirements should ma
AI cancer detection models require calibration to attain the desired balance between cancer detection rate (CDR) and false positive rate. In this study, we simulate the impact of six types of mismatches between the calibration population and the clinical target population, by creating purposefully non-representative datasets to calibrate AI for clinical settings. Mismatching the acquisition year b
In this paper we show that OpenAI’s Large Language Model (LLM) GPT perform remarkably well when used for title and abstract eligibility screening of scientific articles and within a (systematic) literature review workflow. We evaluated GPT on screening data from a systematic review study on electric vehicle charging infrastructure demand with almost 12,000 records using the same eligibility criter
Global policies, legislation, and eco-friendly initiatives have induced the steel industry to integrate sustainable development approaches. Sustainability requires all phases from raw material sourcing to transportation to waste and carbon footprint elimination—yielding positive effects. This research employs a two-step approach in sustainability. The first phase entails conducting a systematic li
The delay between the origin of animals in the Neoproterozoic and their Cambrian diversification remains perplexing. Animal diversification mirrors an expansion in marine shelf area under a greenhouse climate, though the extent to which these environmental conditions directly influenced physiology and early organismal ecology remains unclear. Here, we use a biogeochemical model to quantify oxygen
Key questions for understanding hippocampal function in memory and navigation in humans are the type and source of visual information that reaches the human hippocampus. We measured bidirectional pairwise effective connectivity with functional magnetic resonance imaging between 360 cortical regions while 956 Human Connectome Project participants viewed scenes, faces, tools, or body parts. We devel
Naturvetenskap, teknik, ingenjörsvetenskap och matematik, på engelska ofta grupperade under akronymen STEM, är traditionellt mansdominerade områden. Särskilt inom ingenjörsvetenskap och teknologi är kvinnor fortfarande kraftigt underrepresenterade. Bristen på kvinnor inom STEM innebär utmaningar i att möta arbetsmarknadens behov, för produktkvalitet på grund av brist på olika perspektiv i designprScience, technology, engineering and mathematics, often grouped under the acronym STEM, are traditionally male dominated fields. Especially in engineering and technology, women continue to be heavily underrepresented. The lack of women in STEM poses challenges for meeting the labor market demands, for product quality due to a lack of diverse perspectives in the design process, and for gender equal
How we teach is strongly influenced by the culture we teach in, especially what (we believe) our colleagues think is good and acceptable. Understanding the reluctance to changes in teaching practice, including fear of disapproval from colleagues and students, investigating and reappraising those fears, and starting to talk about alternative interpretations is a first step towards overcoming the in
BACKGROUNDDistinguishing wide complex tachycardia (WCT) as ventricular tachycardia (VT) or supraventricular WCT (SWCT) is critical yet challenging. Manual ECG algorithms require substantial expertise and are inconsistently applied, and contemporary computerized ECG interpretation (CEI) systems often return only a generic “wide complex tachycardia” label. Novel machine learning–based ECG models (So
The recognition of amine groups by ninhydrin, along with a simple mathematical algorithm, showed that di- and tripeptides derived from dietary protein are the major end products of protein digestion entering the blood postprandially. There are thousands of oligopeptides appearing in the gut during protein digestion. However, the presented study on a pig model clearly shows that peptides longer tha
We study the problems of computing the Voronoi diagram and a triangulation of a set of n2 points with O(logn)-bit coordinates in the Euclidean plane in a substantially sublinear in n number of rounds in the congested clique model with n nodes. First, we observe that if the points are uniformly at random distributed in a unit square then their Voronoi diagram within the square can be computed in O
We present a numerical scheme for the solution of the initial-value problem for the “bad” Boussinesq equation. The accuracy of the scheme is tested by comparison with exact soliton solutions as well as with recently obtained asymptotic formulas for the solution.
On October 9, 2023, Harvard University Professor Claudia Goldin received the Sveriges Riksbank Prize in Economic Sciences in Memory of Alfred Nobel, a landmark achievement that not only celebrates her outstanding contributions but also highlights the profound impact an economist can have on society.
Changes in biomarker levels of Alzheimer’s disease (AD) reflect underlying pathophysiological changes in the brain and can provide evidence of direct and downstream treatment effects linked to disease modification. Recent results from clinical trials of anti–amyloid β (Aβ) treatments have raised the question of how to best characterize the relationship between AD biomarkers and clinical endpoints.
