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It is generally accepted that there were well-established relationships between castles and commerce in medieval Sweden. However, to date, the complexities of those relationships have arguably not been fully explored. Through focusing on archaeological evidence from three very different examples, Stockholm, Borgholm and Piksborg, this paper seeks to illustrate the variety of often intimate and com
Moth wings are densely covered by wing scales that are assumed to specifically function to camouflage nocturnally active species during day time. Generally, moth wing scales are built according to the basic lepidopteran Bauplan, where the upper lamina consists of an array of parallel ridges and the lower lamina is a thin plane. The lower lamina hence acts as a thin film reflector having distinct reflec
The underlying molecular mechanisms in osteoarthritis (OA) development are largely unknown. This study explores the proteome and the pairwise interplay of proteins in synovial fluid from patients with late-stage knee OA (arthroplasty), early knee OA (arthroscopy due to degenerative meniscal tear) and from deceased controls without knee OA.Synovial fluid samples were analyzed using state-of-the-art
27-hydroxycholesterol (27HC), synthesized from cholesterol by the enzyme CYP27A1, differentially impacts estrogen receptor positive (ER+) breast cancer (BC) cell growth depending on estrogen levels. This study examined the association between CYP27A1 expression and prognosis in a cohort of 193 premenopausal patients with lymph node-negative primary BC with limited exposure to adjuvant systemic can
The transition to farming in the coastal environments of southern Scandinavia remains a key conundrum in European prehistory. This region was heavily exploited by Late Mesolithic communities of the Ertebølle culture, complex hunter-fisher-gatherers who flourished for some 1500 years prior to the arrival of farming at around 4000 BCE marking the start of the Neolithic period. Extensive genetic and
The Membership of the European Union, brings along guidelines for national tax provisions, securing the freedoms of movement which exists within the European Community. It is above all the four fundamental freedoms of the EC Treaty, the freedom of movement of goods, service, capital and labour which aim to secure removal of obstacles and safeguard the free movement within the inner market of the C
Objective: To investigate whether increased knee joint loading due to improved ambulatory function and walking speed following weight loss achieved over 16 weeks accelerates symptomatic and structural disease progression over a subsequent 1 year weight maintenance period in an obese population with knee osteoarthritis (OA). Methods: Data from a prospective study of weight loss in obese patients wi
In silico analyses have revealed a conserved protein domain (CHDL) widely present in bacteria that has significant structural similarity to eukaryotic cadherins. A CHDL domain was shown to be present in RapA, a protein that is involved in autoaggregation of Rhizobium cells, biofilm formation, and adhesion to plant roots as shown by us and others. Structural similarity to cadherins suggested calciu
Shrunken Pore Syndrome was recently suggested for the pathophysiologic state in patients characterized by an estimation of their glomerular filtration rate (GFR) based upon cystatin C, which is lower or equal to 60% of their estimated GFR based upon creatinine, i.e. when eGFRcystatin C ≤ 60% of eGFRcreatinine. Not only the cystatin C level, but also the levels of other low molecular mass proteins
