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Background: Complex I (CI or NADH:ubiquinone oxidoreductase) deficiency is the most frequent cause of mitochondrial respiratory chain defect. Successful attempts to rescue CI function by introducing an exogenous NADH dehydrogenase, such as the NDI1 from Saccharomyces cerevisiae (ScNDI1), have been reported although with drawbacks related to competition with CI. In contrast to ScNDI1, which is perm
Aim: Attention-deficit/hyperactivity disorder (ADHD) is the most common diagnosis within child- and adolescent psychiatry. Waiting lists and delayed care are major issues. The aim was to evaluate if standardized care (SC) for assessment and treatment of uncomplicated ADHD would reduce resource utilization and increase satisfaction with preserved improvement within the first year of treatment. Meth
The exact mechanism of action of IVIg in the amelioration of immune thrombocytopenic purpura (ITP) is still unclear. Studies have suggested that IVIg may function through the regulation of cytokines, including interleukin-1 receptor antagonist (IL-1Ra), an inhibitor of phagocytosis. Using a mouse model relevant to ITP, we confirm an increase in mouse serum levels of IL-1Ra after exposure to IVIg,
Aims: The aim of this study was to test a Child-Centred Health Dialogue model for primary prevention of obesity for 4-year-old children in Child Health Services, for its feasibility and the responsiveness of its outcomes. Methods: A feasibility study was set up with a non-randomised quasi-experimental cluster design comparing usual care with a structured multicomponent Child-Centred Health Dialogu
Lemierre syndrome usually affects otherwise healthy adolescents or young adults and occurs at an overall rate of 1 to 10 cases per million person-years with an estimated fatality rate of 4 to 9%. Diagnostic criteria remain debated and include acute neck/head bacterial infection (often tonsillitis caused by anaerobes at high potential for sepsis and vascular invasion, notably Fusobacterium necropho
The study of molecular dynamics involves observations of the motion of nuclei and electrons. While nuclear motion is usually on the picosecond or femtosecond timescale, attosecond precision is necessary to directly observe the motion of electrons. Ultrashort laser pulses have become established as a viable tool for probing femtosecond dynamics by irradiating the target for only extremely short tim
While deforestation and forest degradation have gained attention in recent years not least at the UN climate negotiations, a third “de”, i.e., defaunation, has to a great extent been overlooked. Human-induced faunal loss does not only reduce tree species diversity, but also significantly erodes key ecosystem services and functions and further disadvantages local communities. In this article, we an
The transition to a Circular Economy (CE) requires enabling conditions that remove existing barriers in product life extension and material recovery operations. This contribution investigates barriers to material resource efficiency strategies in the maritime sector in Scandinavia and discusses the potential of policy interventions to enable increased reuse and remanufacturing of ship components.
Depression is one of the most common health problems worldwide but is often undertreated. Internet-delivered cognitive behavioral therapy (ICBT) appears to be an effective treatment option, with the potential to reach a larger proportion of individuals suffering from depression. While many studies have examined the efficacy of ICBT for depression in randomized controlled trials, fewer have focused
Anthropogenic land cover change (ALCC) is the most important transformation of the Earth system that occurred in the preindustrial Holocene, with implications for carbon, water and sediment cycles, biodiversity and the provision of ecosystem services and regional and global climate. For example, anthropogenic deforestation in preindustrial Eurasia may have led to feedb
To investigate how manufacturing errors affect the gear set, a method is developed to calculate the contact stress of a gear set with pitch and involute incline errors. The method is parametric, and a hybrid model is used to model the gear stiffness. Contact outside the line of action is considered.A numerical example is used to show how manufacturing errors can change the contact pressure and cau
Context: Open tools (e.g., Jenkins, Gerrit and Git) offer a lucrative alternative to commercial tools. Many companies and developers from OSS communities make a collaborative effort to improve the tools. Prior to this study, we developed an empirically based theory for companies’ strategic choices on the development of these tools, based on empirical observations in the telecom domain. Aim: The ai
The ligand Ph2PC6H4(CH2N(Me)CO(Et)) reacts with (bis(diphenylphosphino)butane) (2,5-norbornadiene)rhodium tetrafluoroborate (2a) and (bis(diphenylphosphino)ethane)(2,5-norbornadiene) rhodium tetrafluoroborate (2b) at room temperature in the presence of hydrogen to displace the norbornadiene and give the chelate complexes 3a,b, in which the phosphorus and the oxygen atoms are coordinated to give an
Introduction: We assessed whether modest systemic cooling started within 6 hours of symptom onset improves functional outcome at three months in awake patients with acute ischaemic stroke. Patients and methods: In this European randomised open-label clinical trial with blinded outcome assessment, adult patients with acute ischaemic stroke were randomised to cooling to a target body temperature of
Immunoglobulins or antibodies are the main effector molecules of the B-cell lineage and are encoded by hundreds of variable (V), diversity (D), and joining (J) germline genes, which recombine to generate enormous IG diversity. Recently, high-throughput adaptive immune receptor repertoire sequencing (AIRR-seq) of recombined V-(D)-J genes has offered unprecedented insights into the dynamics of IG re
