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In market-driven software development there is a strong need for support to handle congestion in the requirements engineering process, which may occur as the demand for short time-to-market is combined with a rapid arrival of new requirements from many different sources. Automated analysis of the continuous flow of incoming requirements provides an opportunity to increase the efficiency of the requi
AIMS: Despite exclusion of left atrial thrombi by transoesophageal echocardiography, cardioversion-related thromboembolism has been reported in atrial fibrillation or flutter. To define a low-risk group for cardioversion without previous anticoagulation, patients were selected for immediate cardioversion if there were no thrombi, no echo spontaneous contrast and the outflow velocity of the left at
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INTRODUCTION: Studies have shown that adherence to prehospital treatment guidelines, for patients with non-traumatic chest pain is incomplete and that there is a gender difference in treatment provided. PURPOSE: The aim of this study was to examine adherence to guidelines in a nurse-led ambulance system in southern Sweden. METHOD: Retrospective cohort study, including 862 medical records was rev
Background: nonacog beta pegol (N9-GP) is a glycoPEGylated recombinant factor IX (rFIX) molecule with a prolonged half-life. Objectives: To provide information on potential dose regimens for N9-GP for phase 3 pivotal and surgery trials. Methods: A population pharmacokinetic model was developed from single-dose data derived from the first human dose trial with N9-GP in hemophilia B patients, and wa
POU5F1 has two alternatively spliced transcripts: a long (variant 1, NM_002701) and a short (variant 2, NM_203289) transcript. Only variant 1 is a key regulator of pluripotency. Hence, it is important to be able to distinguish this transcript from variant 2 and from the many pseudogenes present in the genome. Previous studies on the expression of POU5F1 were, however, usually carried out without c
Most nuclear medicine clinicians use only visual assessment when interpreting regional cerebral blood flow (rCBF) from single-photon emission computed tomography (SPECT) images in clinical practice. The aims of this study were to develop a new, easy to use, automated method for quantification of rCBF-SPECT and to create normal values by using the method on a normal population. We developed a 3-dim
Although the direction of loads applied to the proximal human femur is unpredictable during sideways fall, most in vitro and numerical simulations refer to a single loading condition (15° internal rotation; 10° adduction), which has been anecdotally suggested in the 1950s. The aim of the present study was to improve in vitro simulations of sideways falls on the proximal femur. An in vitro setup w
PURPOSE: To report an alternative to the fenestrated stent-graft for preserving blood flow to side branches in the sealing zones of aortic stent-grafts. TECHNIQUE: A covered stent is deployed parallel to the main aortic stent-graft, protruding somewhat proximally, like a chimney, to preserve flow to a vital side branch covered by the aortic stent-graft. Use of a chimney graft makes it possible to
Focus on customer and market needs has initialized changes in product development work, which involve integration of industrial design and engineering design functions. Interdisciplinary teams are considered a prerequisite in order to achieve collaboration, and a necessity to meet market demands in new products. However, interdisciplinary teams are inherently associated with collaborative shortco
Background: The transition towards a more sustainable energy system is urgent for addressing global environmental and social challenges, and will require transformative changes including improved energy efficiency in the built environment. To reach identified efficiency potentials, various policy instruments have been introduced but their effects are often unclear. In this paper, we argue that the
The catches of bark beetles (Coleoptera: Scolytidae) were compared between attractive traps releasing semiochemicals and passive traps (cylindrical sticky screens hung, at 10 heights of 0.7-11.5 m, on poles). A central attractive-trap pole was surrounded by three passive-trap poles spaced 50 or 100 m away at the apices of an equilateral triangle. The catches of Tomicus piniperda and other scolytid
The application of one-dimensional nanofibers in the fabrication of an electrode greatly improves the performance of solid oxide fuel cells (SOFCs) due to its advantages on electron transfer and mass transport. Various mixed ionic-electronic conducting materials with perovskites and Ruddlesden-Popper-type metal oxide structures are successfully electrospun into nanofibers in recent years mostly in
In this study, a sediment sequence from Lake Skottenesjön, southern Sweden was investigated to reconstruct the effect of forestry and land-use on erosion rates and delivery of organic and minerogenic matter to the lake. Catchment-scale vegetation changes during the last 1000 years were reconstructed quantitatively using pollen analysis and the Landscape Reconstruction Algorithm (LRA). Organic matt
Background and Aims: We present an open retromuscular mesh technique for incisional hernia repair, the modified peritoneal flap hernioplasty, where the fascia is sutured to the mesh and the hernia sac utilized for anterior mesh coverage. The aim was to describe the modified peritoneal flap hernioplasty technique and to compare it to a retromuscular repair, without component separation, regarding s
Background: Mechanisms related to the influence of diet on the development of cardiovascular disease are not entirely understood, and protein biomarkers may help to understand these pathways. Studies of biomarkers identified with multiplex proteomic methods and dietary patterns are largely lacking. Methods and Results: Dietary patterns were generated through principal component analysis in 2 popul
Oxidation-reduction potential (ORP) is an environmental factor of importance in several biological conversion processes. Lytic polysaccharide monooxygenases (LPMOs) catalyze oxidative disruption of the cellulose chain in the presence of oxygen or hydrogen peroxide and increase enzymatic hydrolysis yields. However, the enzymes are also sensitive to oxidative damage and the level of oxidative agent
Background: The use of in vitro cell cultures is a powerful tool for obtaining key insights into the behaviour and response of cells to interventions in normal and disease situations. Unlike in vivo settings, in vitro experiments allow a fine-tuned control of a range of microenvironmental elements independently within an isolated setting. The recent expansion in the use of three-dimensional (3D) i
Background: Carpal tunnel syndrome (CTS) is a common cause of pain, weakness, sensory loss, and activity limitations. Currently, the most common initial treatment is use of a rigid splint immobilizing the wrist, usually during night-Time, for several weeks. Evidence regarding the efficacy and effect durability of wrist splinting is weak. The treatment is associated with costs and may cause discomf
Nuclear morphometry was performed on the diagnostic biopsy in 65 cases of non-mucinous ovarian carcinoma (FIGO stage IIB-IV) and its prognostic value regarding patient survival after the second-look operation was compared to that of morphology and clinical observations. In a univariate Cox survival analysis four morphometric factors were found to be significant predictors of survival (the standard
